human monocytic ehrlichiosis

同

HME

WordNet

1. sing with closed lips; "She hummed a melody"
2. a humming noise; "the hum of distant traffic" (同)humming
3. be noisy with activity; "This office is buzzing with activity" (同)buzz, seethe
4. sound with a monotonous hum (同)thrum
5. make a low continuous sound; "The refrigerator is humming"
6. relating to a person; "the experiment was conducted on 6 monkeys and 2 human subjects"
7. characteristic of humanity; "human nature"
8. having human form or attributes as opposed to those of animals or divine beings; "human beings"; "the human body"; "human kindness"; "human frailty"

PrepTutorEJDIC

1. 〈ハチ・機械などが〉『ブンブンいう』,ブーンと鳴る / 『鼻歌を歌う』,ハミングスル / (ちゅうちょ・当惑で)ふむふむいう / 《話》〈雰囲気・事業などが〉活気がある,活発に動く;(…で)活気づく《+『with』+『名』》 / …‘を'『ハミングで歌う』,鼻歌を歌って…‘を'(ある状熊に)する / (ハチ・機械などの)『ブンブン』[『うなる音』];鼻歌 / (雑踏などの)ガヤガヤ]いう音],騒音 / ふ‐む,う‐ん(ちゅうちょ・当惑・黙考・疑惑・不快などの声)
2. (動物・神に対して)『人間の』,人の / 『人間らいし』,人間的な,人情味のある / 〈C〉《複数形》(動物に怠して)人間(human being) / 〈U〉《the human》人類

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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2013/11/27 16:56:36」(JST)

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Human monocytic ehrlichiosis
Classification and external resources
Ehrlichia chaffeensis
ICD-9	082.41
DiseasesDB	31131
MedlinePlus	001381
eMedicine	med/3391
MeSH	D016873

Human monocytotropic ehrlichiosis (HME) is a form of ehrlichiosis associated with Ehrlichia chaffeensis.

This bacteria is an obligate intracellular pathogen affecting monocytes and macrophages.

Ecology & Epidemiology

In the USA, HME occurs across the south-central, southeastern, and mid-Atlantic states, regions where both the white-tailed deer (Odocoileus virginianus) and lone star ticks (Amblyomma americanum) thrive.

HME occurs in California in Ixodes pacificus ticks and in Dermacentor variabilis ticks.

Nearly 600 cases were reported to the CDC in 2006. In 2001-2002, the incidence was highest in Missouri, Tennessee, and Oklahoma, as well as in people older than 60.

Symptoms

The most common symptoms are fever, headache, malaise, and muscle aches (myalgia). Compared to human granulocytic ehrlichiosis, rash is more common. Laboratory abnormalities include thrombocytopenia, leukopenia, and elevated liver tests.

The severity of the illness can range from minor or asymptomatic to life-threatening. CNS involvement may occur. A serious septic or toxic shock-like picture can also develop, especially in patients with impaired immunity.

Diagnosis

Tick exposure is often overlooked. For patients living in high-prevalence areas who spend time outdoors, a high degree of clinical suspicion should be employed.

Ehrlichia serologies can be negative in the acute period. PCR is therefore the laboratory diagnostic tool of choice.

Treatment

If Ehrlichiosis is suspected, treatment should not be delayed while waiting for a definitive laboratory confirmation, as prompt doxycycline therapy has been associated with improved outcomes. Doxycycline is the treatment of choice.

Presentation during early pregnancy can complicate treatment.

Rifampin has been used in pregnancy and in patients allergic to doxycycline.

References

See also

• monocyte
• Human granulocytic anaplasmosis
• Human ewingii ehrlichiosis

UpToDate Contents

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• 1. ヒトエーリキア症およびアナプラズマ症 human ehrlichiosis and anaplasmosis
• 2. 酸素維持装置 oxygen conserving devices
• 3. エーリキアの生物学 biology of ehrlichiae
• 4. 犬からの人畜共通感染症 zoonoses from dogs
• 5. 猫からの人畜共通感染症 zoonoses from cats

English Journal

• Comparative speed of kill of sarolaner (Simparica(™)) and afoxolaner (NexGard(®)) against induced infestations of Amblyomma americanum on dogs.

• Six RH1, Everett WR2, Chapin S3, Mahabir SP4.
• Parasites & vectors.Parasit Vectors.2016 Feb 19;9(1):98. doi: 10.1186/s13071-016-1378-8.
• BACKGROUND: The lone star tick, Amblyomma americanum, infests dogs and cats in North America and is the vector of the pathogens that cause monocytic and granulocytic ehrlichiosis in dogs and humans. A parasiticide's speed of kill is important to minimize the direct and deleterious effects of tick in
• PMID 26897175

• Vaccination with an Attenuated Mutant of Ehrlichia chaffeensis Induces Pathogen-Specific CD4+ T Cell Immunity and Protection from Tick-Transmitted Wild-Type Challenge in the Canine Host.

• McGill JL1, Nair AD1, Cheng C1, Rusk RA2, Jaworski DC1, Ganta RR1.
• PloS one.PLoS One.2016 Feb 3;11(2):e0148229. doi: 10.1371/journal.pone.0148229. eCollection 2016.
• Ehrlichia chaffeensis is a tick-borne rickettsial pathogen and the causative agent of human monocytic ehrlichiosis. Transmitted by the Amblyomma americanum tick, E. chaffeensis also causes disease in several other vertebrate species including white-tailed deer and dogs. We have recently described th
• PMID 26841025

• EtpE Binding to DNase X Induces Ehrlichial Entry via CD147 and hnRNP-K Recruitment, Followed by Mobilization of N-WASP and Actin.

• Mohan Kumar D1, Lin M1, Xiong Q1, Webber MJ2, Kural C3, Rikihisa Y4.
• mBio.MBio.2015 Nov 3;6(6):e01541-15. doi: 10.1128/mBio.01541-15.
• Obligate intracellular bacteria, such as Ehrlichia chaffeensis, perish unless they can enter eukaryotic cells. E. chaffeensis is the etiological agent of human monocytic ehrlichiosis, an emerging infectious disease. To infect cells, Ehrlichia uses the C terminus of the outer membrane invasin entry-
• PMID 26530384

Related Links

• Human monocytic ehrlichiosis | definition of human monocytic ...

human monocytic ehrlichiosis. See ehrlichiosis. human monocytic ehrlichiosis Infectious disease An infection by Ehrlichia chaffeensis Vector Lone Star tick–Amblyomma americanum, possibly also Dermacentor variabilis Reservoir ...

• Human Monocytic Ehrlichiosis | Public Health and Medical ...

Human Monocytic Ehrlichiosis Human monocytic ehrlichiosis (HME) is a relatively newly documented disease (1987) caused by a bacterium that develops within white blood cells of mammals. Over 750 human cases have been ...

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★リンクテーブル★

リンク元	「HME」
関連記事	「human」「Ehrlichiosis」「monocytic」

「HME」

　　[★]

同

human monocytic ehrlichiosis

「human」

　　[★]

• n.

• ヒト

• adj.

• ヒトの、ヒト型の

関

ape、hominid、Hominidae、homo、Homo sapiens、human being、human race、human-type、man、Pongidae

　 　 　 　

「Ehrlichiosis」

　　[★]

エーリキア症、エールリヒア症、エールリッヒ症、エールリッヒア症

「monocytic」

　　[★]

• adj.

• 単球の、単球系の、単球性の、単核球性の

関

monocyte