It has been suggested that this article be merged into Tetramer. (Discuss) Proposed since August 2018.
A homotetrameric complex, beta-glucuronidase (a glycosidase). Each subunit has the same amino acid sequence.
A homotetramer is a protein complex made up of four identical subunits which are associated but not covalently bound.[1] A heterotetramer is a 4-subunit complex where one or more subunits differ.[2]
Examples of homotetramers include:
enzymes like beta-glucuronidase (pictured)
export factors such as SecB from Escherichia coli[3]
magnesium ion transporters such as CorA.[4]
lectins such as Concanavalin A
IMPDH and IMPDH2
See also
Tetrameric protein
References
^"GO term: protein homotetramerization". YeastGenome. Archived from the original on 27 September 2011. Retrieved 14 May 2011.
^"GO term: protein heterotetramerization". YeastGenome. Archived from the original on 27 September 2011. Retrieved 14 May 2011.
^Watanabe, M; Blobel, G (April 1989). "Cytosolic factor purified from Escherichia coli is necessary and sufficient for the export of a preprotein and is a homotetramer of SecB". Proceedings of the National Academy of Sciences of the United States of America. 86 (8): 2728–32. doi:10.1073/pnas.86.8.2728. PMC 286991. PMID 2649892.
^Warren, M. A.; Kucharski, L. M.; Veenstra, A.; Shi, L.; Grulich, P. F.; Maguire, M. E. (1 July 2004). "The CorA Mg2+ Transporter Is a Homotetramer". Journal of Bacteriology. 186 (14): 4605–4612. doi:10.1128/JB.186.14.4605-4612.2004. PMC 438605. PMID 15231793.
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A subpopulation of nociceptors, the glial cell line-derived neurotrophic factor (GDNF)-dependent, non-peptidergic C-fibers, expresses a cell-surface glycoconjugate that can be selectively labeled with isolectin B4 (IB4 ), a homotetrameric plant lectin from Griffonia simplicifolia. We show that versi
Protein expression and purification.Protein Expr Purif.2015 Jul;111:42-7. doi: 10.1016/j.pep.2015.03.002. Epub 2015 Mar 11.
Voltage-gated sodium channels participate in the propagation of action potentials in excitable cells. Eukaryotic Navs are pseudo homotetrameric polypeptides, comprising four repeats of six transmembrane segments (S1-S6). The first four segments form the voltage-sensing domain and S5 and S6 create th
Substrate binding properties of potato tuber ADP-glucose pyrophosphorylase as determined by isothermal titration calorimetry.
Cakir B1, Tuncel A1, Green AR2, Koper K1, Hwang SK1, Okita TW3, Kang C4.
FEBS letters.FEBS Lett.2015 Jun 4;589(13):1444-9. doi: 10.1016/j.febslet.2015.04.042. Epub 2015 May 4.
Substrate binding properties of the large (LS) and small (SS) subunits of potato tuber ADP-glucose pyrophosphorylase were investigated by using isothermal titration calorimetry. Our results clearly show that the wild type heterotetramer (S(WT)L(WT)) possesses two distinct types of ATP binding sites,
Reversible Inactivation of an Intracellular Uricase from Bacillus fastidiosus via Dissociation of Homotetramer into Homodimers in Solutions of Low Ionic Strength
Bioscience, biotechnology, and biochemistry 73(9), 2141-2144, 2009-09-23
… By polyacrylamide gel electrophoresis (PAGE), gradient PAGE, sodium-dodecyl-sulfate-PAGE, gel-filtration through Sephadex G200, and activity staining with peroxidase and its chromatogenic substrate, this homotetrameric uricase in water was found to dissociate into inactive homodimers that could form active homotetramers again in solutions of high ionic strength. …
Define Homotetrameric: n. A polymer consisting of four identical monomers. tet′ra·mer′ic adj Homotetrameric - definition of Homotetrameric by The Free Dictionary http://www.thefreedictionary.com/Homotetrameric Printer Friendly ...