ヘテロ核リボヌクレオタンパク質、ヘテロ核内リボタンパク質、ヘテロ核RNAタンパク質

関: heterogeneous-nuclear ribonucleoprotein、heteronuclear ribonucleoprotein

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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2013/02/26 13:25:25」(JST)

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Heterogeneous nuclear ribonucleoproteins (hnRNPs) are complexes of RNA and protein present in the cell nucleus during gene transcription and subsequent post-transcriptional modification of the newly synthesized RNA (pre-mRNA). The presence of the proteins bound to a pre-mRNA molecule serves as a signal that the pre-mRNA is not yet fully processed and ready for export to the cytoplasm. After splicing has occurred, the proteins remain bound to spliced introns and target them for degradation.

The proteins involved in the hnRNP complexes are collectively known as heterogeneous ribonucleoproteins. They include protein K and polypyrimidine tract-binding protein (PTB), which is regulated by phosphorylation catalyzed by protein kinase A and is responsible for suppressing RNA splicing at a particular exon by blocking access of the spliceosome to the polypyrimidine tract.^[1]^:326

Functions

Prevent folding of pre-mRNA into secondary structures that may inhibit its interactions with other proteins.
May associate with the splicing apparatus.
Transport of mRNA out of the nucleus.

The association of a pre-mRNA molecule with a hnRNP particle prevents formation of short secondary structures dependent on base pairing of complementary regions, thereby making the pre-mRNA accessible for interactions with other proteins.

Examples

Human genes encoding heterogeneous nuclear ribonucleoproteins include:

HNRNPA0, HNRNPA1, HNRNPA1L1, HNRNPA1L2, HNRNPA3, HNRNPA2B1
HNRNPAB
HNRNPB1
HNRNPC, HNRNPCL1
HNRNPD, HNRPDL
HNRNPF
HNRNPH1, HNRNPH2, HNRNPH3
HNRNPK
HNRNPL, HNRPLL
HNRNPM
HNRNPR
HNRNPU, HNRNPUL1, HNRNPUL2, HNRNPUL3

References

^ Matsudaira PT, Lodish HF, Berk A, Kaiser C, Krieger M, Scott MP, Bretscher A, Ploegh H (2008). Molecular cell biology. San Francisco: W.H. Freeman. ISBN 0-7167-7601-4.

UpToDate Contents

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1. 混合性結合組織病における抗U1-RNP抗体 anti u1 rnp antibodies in mixed connective tissue disease
2. 混合性結合組織病の臨床症状 clinical manifestations of mixed connective tissue disease

English Journal

Ridaifen G, tamoxifen analog, is a potent anticancer drug working through a combinatorial association with multiple cellular factors.

Ikeda K1, Kamisuki S1, Uetake S2, Mizusawa A2, Ota N2, Sasaki T1, Tsukuda S1, Kusayanagi T1, Takakusagi Y1, Morohashi K3, Yamori T4, Dan S4, Shiina I2, Sugawara F5.
Bioorganic & medicinal chemistry.Bioorg Med Chem.2015 Sep 15;23(18):6118-24. doi: 10.1016/j.bmc.2015.08.001. Epub 2015 Aug 5.
Ridaifen-G (RID-G), a tamoxifen analog that we previously synthesized, has potent growth inhibitory activity against various cancer cell lines. Tamoxifen is an anticancer drug known to act on an estrogen receptor (ER) and other proteins. However, our previous studies interestingly suggested that the
PMID 26314924

FANCM c.5791C>T nonsense mutation (rs144567652) induces exon skipping, affects DNA repair activity and is a familial breast cancer risk factor.

Peterlongo P1, Catucci I2, Colombo M3, Caleca L3, Mucaki E4, Bogliolo M5, Marin M5, Damiola F6, Bernard L7, Pensotti V8, Volorio S8, Dall'Olio V8, Meindl A9, Bartram C10, Sutter C10, Surowy H11, Sornin V6, Dondon MG12, Eon-Marchais S12, Stoppa-Lyonnet D13, Andrieu N12, Sinilnikova OM14; GENESIS, Mitchell G15, James PA15, Thompson E16; kConFab; SWE-BRCA, Marchetti M17, Verzeroli C18, Tartari C17, Capone GL19, Putignano AL19, Genuardi M20, Medici V21, Marchi I21, Federico M21, Tognazzo S22, Matricardi L22, Agata S22, Dolcetti R23, Puppa LD24, Cini G24, Gismondi V25, Viassolo V25, Perfumo C25, Mencarelli MA26, Baldassarri M26, Peissel B27, Roversi G27, Silvestri V28, Rizzolo P28, Spina F29, Vivanet C29, Tibiletti MG30, Caligo MA31, Gambino G31, Tommasi S32, Pilato B32, Tondini C33, Corna C33, Bonanni B34, Barile M34, Osorio A35, Benitez J35, Balestrino L29, Ottini L28, Manoukian S27, Pierotti MA36, Renieri A26, Varesco L25, Couch FJ37, Wang X37, Devilee P38, Hilbers FS39, van Asperen CJ40, Viel A24, Montagna M22, Cortesi L21, Diez O41, Balmaña J42, Hauke J43, Schmutzler RK43, Papi L44, Pujana MA45, Lázaro C45, Falanga A17, Offit K46, Vijai J46, Campbell I47, Burwinkel B11, Kvist A48, Ehrencrona H49, Mazoyer S6, Pizzamiglio S50, Verderio P50, Surralles J5, Rogan PK4, Radice P2.
Human molecular genetics.Hum Mol Genet.2015 Sep 15;24(18):5345-55. doi: 10.1093/hmg/ddv251. Epub 2015 Jun 30.
Numerous genetic factors that influence breast cancer risk are known. However, approximately two-thirds of the overall familial risk remain unexplained. To determine whether some of the missing heritability is due to rare variants conferring high to moderate risk, we tested for an association betwee
PMID 26130695

LIN28A Modulates Splicing and Gene Expression Programs in Breast Cancer Cells.

Yang J1, Bennett BD2, Luo S3, Inoue K1, Grimm SA2, Schroth GP3, Bushel PR4, Kinyamu HK5, Archer TK5.
Molecular and cellular biology.Mol Cell Biol.2015 Sep 15;35(18):3225-43. doi: 10.1128/MCB.00426-15. Epub 2015 Jul 6.
LIN28 is an evolutionarily conserved RNA-binding protein with critical functions in developmental timing and cancer. However, the molecular mechanisms underlying LIN28's oncogenic properties are yet to be described. RNA-protein immunoprecipitation coupled with genome-wide sequencing (RIP-Seq) analys
PMID 26149387

Japanese Journal

Sequence requirements for RNA binding by HuR and AUF1

Barker Andrew,Epis Michael R.,Porter Corrine J. [他]
Journal of Biochemistry 151(4), 423-437, 2012-04-00
NAID 40019220570

An X-chromosome RNA-binding motif protein (RBMX) is required for proper kinetochore formation

Hann Lee Mei,Lin Linyen,Takata Hideaki [他],MORIMOTO Akihiro,UCHIYAMA Susumu,MATSUNAGA Sachihiro,FUKUI Kiichi
Chromosome science 14(1), 17-21, 2012-03-01
RBMX is an RNA-binding motif protein identified as a component of purified human metaphase chromosomes. We have analyzed the functional significance of RBMX by electron microscopy (EM) in combination …
NAID 10030317380

博慈会ダ・ビンチ賞 HnRNP A3は血液凝固第9因子の年齢軸遺伝子発現増加エレメントRNAに結合する肝臓核蛋白質--老化や年齢に伴う疾患研究に新しい道を開く蛋白質の同定 (平成23年度助成研究論文)

浜田俊幸
未病と抗老化 20(1), 70-86, 2011-06-00
NAID 40018889573

「ヘテロ核RNAタンパク質」

　　[★]

英: heterogeneous-nuclear ribonucleoprotein、heteronuclear ribonucleoprotein、hnRNP
関: 不均一核内リボタンパク質、ヘテロ核内リボタンパク質、ヘテロ核リボヌクレオタンパク質

「ヘテロ核リボヌクレオタンパク質」

　　[★]

英: heterogeneous-nuclear ribonucleoprotein、heteronuclear ribonucleoprotein、hnRNP
関: 不均一核内リボタンパク質、ヘテロ核内リボタンパク質、ヘテロ核RNAタンパク質

「heteronuclear ribonucleoprotein」

　　[★]

ヘテロ核リボヌクレオタンパク質、ヘテロ核内リボタンパク質、ヘテロ核RNAタンパク質

関: heterogeneous-nuclear ribonucleoprotein、hnRNP

「ヘテロ核内リボタンパク質」

　　[★]

英: heteronuclear ribonucleoprotein、hnRNP
関: 不均一核内リボタンパク質、ヘテロ核RNAタンパク質、ヘテロ核リボヌクレオタンパク質

「heterogeneous-nuclear ribonucleoprotein」

　　[★]

ヘテロ核リボヌクレオタンパク質、不均一核内リボタンパク質、ヘテロ核RNAタンパク質

関: heteronuclear ribonucleoprotein、hnRNP

「hnRNP D」

　　[★]

ヘテロ核リボヌクレオタンパク質D

関: heterogeneous-nuclear ribonucleoprotein D

「hnRNP K」

　　[★]

ヘテロ核リボヌクレオタンパク質K

関: heterogeneous-nuclear ribonucleoprotein K

「hnRNP L」

　　[★]

ヘテロ核リボヌクレオタンパク質L

関: heterogeneous-nuclear ribonucleoprotein L

「hnRNP C」

　　[★]

ヘテロ核リボヌクレオタンパク質C

[isbn0-7167-7601-4-1] Matsudaira PT, Lodish HF, Berk A, Kaiser C, Krieger M, Scott MP, Bretscher A, Ploegh H (2008). Molecular cell biology. San Francisco: W.H. Freeman. ISBN 0-7167-7601-4.

リンク元	「ヘテロ核RNAタンパク質」「ヘテロ核リボヌクレオタンパク質」「heteronuclear ribonucleoprotein」「ヘテロ核内リボタンパク質」「heterogeneous-nuclear ribonucleoprotein」
拡張検索	「hnRNP D」「hnRNP K」「hnRNP L」「hnRNP C」

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案内

hnRNP