histone methyltransferase

出典: meddic


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出典(authority):フリー百科事典『ウィキペディア(Wikipedia)』「2015/10/03 00:58:18」(JST)

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  • Statins inhibit tumor progression via an enhancer of zeste homolog 2-mediated epigenetic alteration in colorectal cancer.
  • Ishikawa S1, Hayashi H, Kinoshita K, Abe M, Kuroki H, Tokunaga R, Tomiyasu S, Tanaka H, Sugita H, Arita T, Yagi Y, Watanabe M, Hirota M, Baba H.
  • International journal of cancer. Journal international du cancer.Int J Cancer.2014 Dec 1;135(11):2528-36. doi: 10.1002/ijc.28672. Epub 2014 Jan 6.
  • While statin intake has been proven to reduce the risk of colorectal cancer (CRC), the mechanism of antitumor effects and clinical significance in survival benefits remain unclear. Statin-induced antiproliferative effects and its underlying mechanism were examined using six CRC cell lines. Statins e
  • PMID 24346863
  • MRTF-A steers an epigenetic complex to activate endothelin-induced pro-inflammatory transcription in vascular smooth muscle cells.
  • Yang Y1, Cheng X2, Tian W2, Zhou B2, Wu X2, Xu H2, Fang F2, Fang M3, Xu Y4.
  • Nucleic acids research.Nucleic Acids Res.2014 Dec 1;42(16):10460-72. doi: 10.1093/nar/gku776. Epub 2014 Aug 26.
  • Endothelin (ET-1) was initially identified as a potent vasoconstrictor contributing to the maintenance of vascular rhythm. Later studies have implicated ET-1, when aberrantly up-regulated within the vasculature, in a range of human pathologies associated with disruption of vascular homeostasis. ET-1
  • PMID 25159611
  • Histone H3K4 methyltransferase Mll1 regulates protein glycosylation and tunicamycin-induced apoptosis through transcriptional regulation.
  • Wang X1, Ju L1, Fan J1, Zhu Y1, Liu X1, Zhu K1, Wu M2, Li L3.
  • Biochimica et biophysica acta.Biochim Biophys Acta.2014 Nov;1843(11):2592-602. doi: 10.1016/j.bbamcr.2014.06.013. Epub 2014 Jun 28.
  • Disrupting protein glycosylation induces ER (endoplasmic reticulum) stress, resulting in the activation of UPR (unfolded protein response) pathways. A key function of the UPR is to restore ER homeostasis, but prolonged or unsolved ER stress can lead to apoptosis. MLL1 (Mixed Lineage Leukemia 1, also
  • PMID 24983772


  • Development of Functional Molecules for Elucidation of the Physiological Roles of Several Nuclear Receptors and Their Endogenous Ligands
  • Hirano Tomoya
  • Chemical and pharmaceutical bulletin 61(2), 111-120, 2013-02
  • NAID 40019558458
  • RNA and epigenetic silencing : Insight from fission yeast
  • GOTO Derek B.,NAKAYAMA Jun-ichi
  • Development, growth & differentiation 54(1), 129-141, 2012-01-01
  • NAID 10030405256
  • アルギニンメチル化の生理的役割 (内分泌) -- (基礎分野での進歩)
  • 高橋 悠太,深水 昭吉
  • Annual review. 糖尿病・代謝・内分泌 2012(-), 170-175, 2012
  • NAID 40019174963


Histone methyltransferases (HMT) are histone-modifying enzymes, (including histone-lysine N-methyltransferase and histone-arginine N-methyltransferase), that catalyze the transfer of one, two, or three methyl groups to lysine and arginine ...
Histone methyltransferase inhibitors used for various assays, some have entered clinical trials, which would be new cancer therapies. ... Cat.No. Product Name Information Product Use Citation Customer Product Validation





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WordNet   license wordnet

「a simple protein containing mainly basic amino acids; present in cell nuclei in association with nucleic acids」



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