ヒストン脱アセチル化

WordNet

a simple protein containing mainly basic amino acids; present in cell nuclei in association with nucleic acids

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1. 急性前骨髄球性白血病の分子生物学 molecular biology of acute promyelocytic leukemia
2. エストロゲン作用の分子生物学および生理学 molecular biology and physiology of estrogen action
3. 毛細血管拡張性運動失調症 ataxia telangiectasia
4. 遺伝性疾患の基本原則 basic principles of genetic disease
5. 免疫調節および抗線維化による全身性硬化症（強皮症）治療 immunomodulatory and antifibrotic approaches to the treatment of systemic sclerosis scleroderma

English Journal

Histone deacetylases in cardiac fibrosis: Current perspectives for therapy.

Tao H1, Shi KH2, Yang JJ3, Huang C4, Zhan HY1, Li J5.Author information 1Department of Cardiothoracic Surgery, The Second Hospital of Anhui Medical University, Hefei 230601, China; Cardiovascular Research Center, Anhui Medical University, Hefei 230601, China.2Department of Cardiothoracic Surgery, The Second Hospital of Anhui Medical University, Hefei 230601, China; Cardiovascular Research Center, Anhui Medical University, Hefei 230601, China. Electronic address: ayskh3@hotmail.com.3School of Pharmacy, Anhui Medical University, Hefei 230032, China; Department of Pharmacology, The Second Hospital of Anhui Medical University, Hefei 230601, China.4School of Pharmacy, Anhui Medical University, Hefei 230032, China.5School of Pharmacy, Anhui Medical University, Hefei 230032, China. Electronic address: yncs01@hotmail.com.AbstractCardiac fibrosis is an important pathological feature of cardiac remodeling in heart diseases. The molecular mechanisms of cardiac fibrosis are unknown. Histone deacetylases (HDACs) are enzymes that balance the acetylation activities of histone acetyltransferases on chromatin remodeling and play essential roles in regulating gene transcription. In recent years, the role of HDACs in cardiac fibrosis initiation and progression, as well as the therapeutic effects of HDAC inhibitors, has been well studied. Moreover, numerous studies indicated that HDAC activity is associated with the development and progression of cardiac fibrosis. In this review, the innovative aspects of HDACs are discussed, with respect to biogenesis, their role in cardiac fibrosis. Furthermore, the potential applications of HDAC inhibitors in the treatment of cardiac fibrosis associated with fibroblast activation and proliferation.
Cellular signalling.Cell Signal.2014 Mar;26(3):521-7. doi: 10.1016/j.cellsig.2013.11.037. Epub 2013 Dec 7.
Cardiac fibrosis is an important pathological feature of cardiac remodeling in heart diseases. The molecular mechanisms of cardiac fibrosis are unknown. Histone deacetylases (HDACs) are enzymes that balance the acetylation activities of histone acetyltransferases on chromatin remodeling and play ess
PMID 24321371

Control of Drosophila embryo patterning by transcriptional co-regulators.

Mannervik M.Author information Department of Molecular Biosciences, The Wenner-Gren Institute, Stockholm University, Arrheniuslaboratories E3, SE-106 91 Stockholm, Sweden. Electronic address: mattias.mannervik@su.se.AbstractA combination of broadly expressed transcriptional activators and spatially restricted repressors are used to pattern embryos into cells of different fate. Transcriptional co-regulators are essential mediators of transcription factor function, and contribute to selective transcriptional responses in embryo development. A two step mechanism of transcriptional regulation is discussed, where remodeling of chromatin is initially required, followed by stimulation of recruitment or release of RNA polymerase from the promoter. Transcriptional co-regulators are essential for both of these steps. In particular, most co-activators are associated with histone acetylation and co-repressors with histone deacetylation. In the early Drosophila embryo, genome-wide studies have shown that the CBP co-activator has a preference for associating with some transcription factors and regulatory regions. The Groucho, CtBP, Ebi, Atrophin and Brakeless co-repressors are selectively used to limit zygotic gene expression. New findings are summarized which show that different co-repressors are often utilized by a single repressor, that the context in which a co-repressor is recruited to DNA can affect its activity, and that co-regulators may switch from co-repressors to co-activators and vice versa. The possibility that co-regulator activity is regulated and plays an instructive role in development is discussed as well. This review highlights how findings in Drosophila embryos have contributed to the understanding of transcriptional regulation in eukaryotes as well as to mechanisms of animal embryo patterning.
Experimental cell research.Exp Cell Res.2014 Feb 1;321(1):47-57. doi: 10.1016/j.yexcr.2013.10.010. Epub 2013 Oct 22.
A combination of broadly expressed transcriptional activators and spatially restricted repressors are used to pattern embryos into cells of different fate. Transcriptional co-regulators are essential mediators of transcription factor function, and contribute to selective transcriptional responses in
PMID 24157250

Activation of p53 by spermine mediates induction of autophagy in HT1080 cells.

Chae YB1, Kim MM2.Author information 1Department of Chemistry, Dong-Eui University, Busan 614-714, Republic of Korea.2Department of Chemistry, Dong-Eui University, Busan 614-714, Republic of Korea. Electronic address: mmkim@deu.ac.kr.AbstractThe recent evidences indicate that autophagy is associated with a number of pathological processes including cancer, muscular disorder and neurodegeneration in addition to longevity. The efficacy of spermine was investigated on induction of autophagy through histone deacetylation and p53 activation in human fibrosarcoma cell line, HT1080. In this study, it was discovered that spermine increases the activity of HAT and autophagy. It was also identified that the transcriptional activation of p53 and the activation of p21 promoter by spermine are related to the induction of autophagy in reporter gene assay. Furthermore, western blot analyses demonstrated that spermine modulates the expression of proteins related to autophagy and apoptosis. The expression levels of Ac-histone H3, HDAC1, HAT1, p300 and SIRT1 were increased in HT1080 cells treated with spermine. In addition, the expression levels of protein such as acetyl-p53, p-p53, Bcl-2 and caspase-9 inducing apoptosis were increased in the presence of spermine. Moreover, the levels of Mdm2 and caspase-3 expression were reduced in the cells exposed to spermine compared to blank group. These results suggest that activation of HAT in the presence of spermine promotes the induction of autophagy in HT1080 cells through the enhanced activity of p-p53 and acetyl p53.
International journal of biological macromolecules.Int J Biol Macromol.2014 Feb;63:56-63. doi: 10.1016/j.ijbiomac.2013.10.041. Epub 2013 Nov 1.
The recent evidences indicate that autophagy is associated with a number of pathological processes including cancer, muscular disorder and neurodegeneration in addition to longevity. The efficacy of spermine was investigated on induction of autophagy through histone deacetylation and p53 activation
PMID 24189165

Japanese Journal

青年期の豊かな環境はフェンシクリジン連続投与マウスのヒストンアセチル化に関連した行動異常を予防する

古関竹直,毛利彰宏,間宮隆吉,青山雄紀,鳥海和也,鈴木静香,中島杏紗,山田卓摩,永井拓,鍋島俊隆
日本神経精神薬理学雑誌 = Japanese journal of psychopharmacology 32(2), 87-89, 2012-04-25
NAID 10030656936

エストラジオールによるプロテインS遺伝子の発現抑制機構

鈴木敦夫
日本血栓止血学会誌 23(4), 407-414, 2012
NAID 130002076995

Different Involvement of DNA Methylation and Histone Deacetylation in the Expression of Solute-Carrier Transporters in 4 Colon Cancer Cell Lines

Ikehata Mika,Ueda Kumiko,Iwakawa Seigo
Biological and Pharmaceutical Bulletin 35(3), 301-307, 2012
… The purpose of this study on the involvement of epigenetic control of the expression of solute carrier (SLC) transporters by DNA methylation and histone deacetylation in 4 colon cancer cells is to find the epigenetic control mechanisms of drug transporters in colon cancers. … Human colon cancer cell lines (HCT116, HT29, SW48, SW480) were treated with 5-aza-2′-deoxycytidine (DAC), as a DNA methyltransferase inhibitor, followed by trichostatin A (TSA), as a histone deacetylase inhibitor. …
NAID 130001872309