WordNet

a depression scratched or carved into a surface (同)scratch, prick, slit, dent
the cutting of or into body tissues or organs (especially by a surgeon as part of an operation) (同)section, surgical incision
of or relating to histology (同)histologic

PrepTutorEJDIC

〈U〉切り込むこと,刻み込むこと

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1. 開腹手術における切開 incisions for open abdominal surgery
2. 帝王切開：手技 cesarean delivery technique
3. 帝王切開の再施行 repeat cesarean delivery
4. 乳房切除：適応、種類、および切除時の腋窩リンパ節マネージメント mastectomy indications types and concurrent axillary lymph node management
5. 乳房温存療法 breast conserving therapy

English Journal

Improvement of orthotopic lung cancer mouse model via thoracotomy and orotracheal intubation enabling in vivo imaging studies.

Im GH1, Jang MS, Chung JJ, Kim KN, Kim JH, Kim SI, Lee JH.Author information 1Department of Radiology, Samsung Medical Center, Sungkyunkwan University School of Medicine and Center for Molecular and Cellular Imaging, Samsung Biomedical Research Institute, Seoul, Republic of Korea.AbstractInvestigation of molecular mechanisms and the efficiency of novel therapeutics for the treatment and prevention of a disease require accurate and accessible preclinical models. Recent developments in personalized medicine employing molecular medicine concepts have favored mice because their genetic make-up is well known and easy to manipulate. For lung cancer, however, orthotopic models in mice are difficult to create due to their narrow glottis openings which act as obstacles to intubation. In the present study, we develop an orotracheal intubation device which gives a clearer view of the narrow mouse glottis and increases the success rate of intubation. We achieved anesthetization via orotracheal intubation using this novel device and then performed a thoracotomy by making an incision between the fourth and fifth intercostal ribs on the right side of the chest. Lung tumor cells were then inoculated at this site. Tumor formation was monitored through bioluminescence optical and magnetic resonance (MR) imagings, which was confirmed by histological analysis. Temperature drop (<35) and/or loss of body weight (>30% of the initial body weight) observed during any procedure were used as interruption criteria. This method exhibited high tumorigenicity (100%) and a low mortality rate (8%) at specific sites making it ideal for creating orthotopic lung tumor models and making it particularly useful for sequential follow-up studies using in vivo image analysis.
Laboratory animals.Lab Anim.2014 Apr;48(2):124-31. doi: 10.1177/0023677213512821. Epub 2013 Nov 20.
Investigation of molecular mechanisms and the efficiency of novel therapeutics for the treatment and prevention of a disease require accurate and accessible preclinical models. Recent developments in personalized medicine employing molecular medicine concepts have favored mice because their genetic
PMID 24257968

The beneficial effects of 18β-glycyrrhetinic acid following oxidative and neuronal damage in brain tissue caused by global cerebral ischemia/reperfusion in a C57BL/J6 mouse model.

Oztanir MN1, Ciftci O, Cetin A, Durak MA, Basak N, Akyuva Y.Author information 1Department of Brain and Neurosurgery, Faculty of Medicine, University of Inonu, 44280, Malatya, Turkey, mustafa.oztanir@inonu.edu.tr.AbstractThis study investigated the effects of 18β-glycyrrhetinic acid (GA) on neuronal damage in brain tissue caused by global cerebral ischemia/reperfusion (I/R) in C57BL/J6 mice. All subjects (n = 40) were equally divided into four groups: (1) sham-operated (SH), (2) I/R, (3) GA, and (4) GA+I/R. The SH group was used as a control. In the I/R group, the bilateral carotid arteries were clipped for 15 min, and the mice were treated with the vehicle for 10 days. In the GA group, mice were given GA (100 mg/kg) for 10 days following a median incision without carotid occlusion. In the GA+I/R group, the I/R model was applied to the mice exactly as in the I/R group, and they were then treated with the same dose of GA for 10 days. Cerebral I/R significantly induced oxidative stress via an increase in lipid peroxidaitons and a decrease in elements of the antioxidant defense systems. However, GA treatment was protective against the oxidative effects of I/R by inducing significant increases in antioxidant defense systems and a significant decrease of lipid peroxidations. Additionally, cerebral I/R increased the incidence of histopathological damage and apoptosis in brain tissue, but these neurodegenerative effects were eliminated by GA treatment. Therefore, the current study demonstrated that GA treatment effectively prevents oxidative and histological damage in the brain caused by global I/R. In this context, GA may be useful for the attenuation of the negative effects of global cerebral I/R and, in the future, it may be a viable and safe alternative treatment for ischemic stroke in humans.
Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology.Neurol Sci.2014 Feb 20. [Epub ahead of print]
This study investigated the effects of 18β-glycyrrhetinic acid (GA) on neuronal damage in brain tissue caused by global cerebral ischemia/reperfusion (I/R) in C57BL/J6 mice. All subjects (n = 40) were equally divided into four groups: (1) sham-operated (SH), (2) I/R, (3) GA, and (4) GA+I/R. The S
PMID 24554419

Submucosal tunneling endoscopic resection for small upper gastrointestinal subepithelial tumors originating from the muscularis propria layer.

Ye LP1, Zhang Y, Mao XL, Zhu LH, Zhou X, Chen JY.Author information 1Department of Gastroenterology, Taizhou Hospital of Zhejiang Province, Wenzhou Medical College, 150 Ximen Street, Linhai, 317000, Zhejiang, People's Republic of China.AbstractBACKGROUND: This prospective study was designed to evaluate the safety and efficacy of submucosal tunneling endoscopic resection (STER) for small (≤3 cm) upper gastrointestinal (GI) subepithelial tumors (SETs) originating from the muscularis propria (MP) layer.
Surgical endoscopy.Surg Endosc.2014 Feb;28(2):524-30. doi: 10.1007/s00464-013-3197-8. Epub 2013 Sep 7.
BACKGROUND: This prospective study was designed to evaluate the safety and efficacy of submucosal tunneling endoscopic resection (STER) for small (≤3 cm) upper gastrointestinal (GI) subepithelial tumors (SETs) originating from the muscularis propria (MP) layer.METHODS: Between August 2011 and Feb
PMID 24013472

Japanese Journal

非医原性 parasitic myoma と考えられた一例

平池春子,平池修,白根晃,池田悠至,宮本雄一郎,兵藤博恵,合阪幸三,小畑清一郎
日本産科婦人科内視鏡學會雜誌 = The journal of the Japan Endoscopy Society of Obstetrics and Gynecology 28(1), 342-345, 2012-08-01
… Morcellation instruments are widely used to remove large myomas through small abdominal incision sites. … Histological diagnosis confirmed that these lesions were compatible with uterine leiomyoma.<BR><B>Conclusion:</B> …
NAID 10031121786

単孔式腹腔鏡を用いて切除した回盲部重複腸管の1例

阪龍太,奥山宏臣,佐々木隆士 [他],野瀬聡子
日本小児外科学会雑誌 48(4), 770-774, 2012-06-20
単孔式腹腔鏡を用いて切除しえた回腸末端の重複腸管を経験したので報告する.症例は3か月の女児.胎児期より腹腔内嚢胞を認めたため出生後に当院に紹介となった.超音波検査では嚢胞内に"double wall sign"を認め,CTで腫瘤は回腸末端を圧迫していた.手術はまず臍縦切開を5mm頭側に延長してラップディスク^[○!R]とEZアクセス^[○!R]を装着して,2ポートで腹腔鏡操作を行った.腫瘤は回腸末 …
NAID 110009470934

頚部から胸腔内におよぶ巨大デスモイドの1切除例

橋本章太郎,西尾渉,田根慎也,真庭謙昌,吉村雅裕
日本呼吸器外科学会雑誌 = The journal of the Japanese Association for Chest Surgery 25(7), 732-735, 2011-11-15
… ころ，右頚部から胸腔内におよび上縦隔を左側に圧排する巨大な腫瘍を指摘された．生検にてsolitary fibrous tumorが疑われ，手術目的に入院となった．手術は耳鼻咽喉科と共同にて施行した．modified hemi-clamshell incisionにてアプローチし，腫瘍摘出術および右鎖骨下動脈再建術を施行した．第5，7，8頚椎椎間孔周囲の腫瘍は神経温存のため不完全切除とした．病理組織診ではdesmoid tumorと診断された．腫瘍残存部には術後放射 …
NAID 10029652457