histamine-1 receptor antagonists

WordNet

a drug that neutralizes or counteracts the effects of another drug
a muscle that relaxes while another contracts; "when bending the elbow the triceps are the antagonist"
amine formed from histidine that stimulates gastric secretions and dilates blood vessels; released by the human immune system during allergic reactions
a cellular structure that is postulated to exist in order to mediate between a chemical agent that acts on nervous tissue and the physiological response

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Aryl hydrocarbon receptor negatively regulates LPS-induced IL-6 production through suppression of histamine production in macrophages.

Masuda K, Kimura A, Hanieh H, Nguyen NT, Nakahama T, Chinen I, Otoyo Y, Murotani T, Yamatodani A, Kishimoto T.SourceLaboratory of Immune Regulation, Graduate School of Frontier Biosciences, Osaka University, 1-3 Yamadaoka, Suita, Osaka 565-0871, Japan.
International immunology.Int Immunol.2011 Oct;23(10):637-45. Epub 2011 Sep 19.
Macrophages play a pivotal role in innate immune responses to pathogens via toll-like receptors. We previously demonstrated that aryl hydrocarbon receptor (Ahr) in combination with signal transducer and activator of transcription 1 (Stat1) negatively regulates pro-inflammatory cytokine production by
PMID 21930594

Extracellular Ca(2+) entry and mobilization of inositol trisphosphate-dependent Ca(2+) stores modulate histamine and electrical field stimulation induced contractions of the guinea-pig prostate.

Lam M, Kerr K, Ventura S, Exintaris B.SourceMedicinal Chemistry and Drug Action, Monash Institute of Pharmaceutical Sciences, Monash University, 381 Royal Parade, Parkville, Victoria 3052, Australia.
Pharmacological research : the official journal of the Italian Pharmacological Society.Pharmacol Res.2011 Sep;64(3):235-41. Epub 2011 Apr 25.
This investigation aimed to examine the source of Ca(2+) mobilization that leads to the contractile response to either exogenously added histamine (1 μM-1mM) or electrical field stimulation (10Hz, 0.5ms, 60V). Removal of extracellular Ca(2+) by removal of Ca(2+) from the bathing medium reduced hist
PMID 21536131

Fukumoto Junji
Yonago Acta medica 38(2), 85-94, 1995-07
… The effects of histamine on mucin secretion from the rat submandibular gland were examined, and compared with those of β-adrenergic and cholinergic agonists. … Histamine (1 mmol/L) elicited a 1.7-fold increase in mucin secretion compared with that of the unstimulated control while isoproterenol carbachol and pilocarpine (0.1 mmol/L) caused 3.3-, 1.6- and 1.3-fold increases, respectively. …
NAID 110006443212