hippocalcin

ヒ・カルシン

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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2015/06/02 07:41:25」(JST)

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Hippocalcin
Identifiers
Symbols	HPCA ; BDR2
External IDs	OMIM: 142622 MGI: 1336200 HomoloGene: 55634 GeneCards: HPCA Gene
Gene ontology Molecular function • actin binding • calcium ion binding Biological process • inner ear development Sources: Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	3208	15444
Ensembl	ENSG00000121905	ENSMUSG00000028785
UniProt	P84074	P84075
RefSeq (mRNA)	NM_002143	NM_001130419
RefSeq (protein)	NP_002134	NP_001123891
Location (UCSC)	Chr 1: 33.35 – 33.36 Mb	Chr 4: 129.11 – 129.12 Mb
PubMed search	[1]	[2]

Hippocalcin is a protein that in humans is encoded by the HPCA gene.

Hippocalcin is a calcium-binding protein that belongs to the neuronal calcium sensor (NCS) family of proteins. It is expressed in mammalian brains especially in the hippocampus. It possesses a Ca²⁺/myristoyl switch.

Processes

Hippocalcin takes part in the following processes:

• Activation of PLD1 and PLD2 expression
• Inhibition of apoptosis
• MAP kinase signalling
• Involved in long term depression in hippocampal neuron
• Required for normal spatial learning

Interactions

Hippocalcin interacts with following proteins:

• Neuronal apoptosis inhibitory protein (NAIP)
• Mixed lineage kinase 2 (MLK2) – MLK2 is myosin light chain kinase 2
• The b2 adaptin of the AP2 complex
• Calcium-dependent activator protein for secretion (CADPS)

References

Further reading

• Hidaka H, Okazaki K (1993). "Neurocalcin family: a novel calcium-binding protein abundant in bovine central nervous system". Neurosci. Res. 16 (2): 73–7. doi:10.1016/0168-0102(93)90074-Z. PMID 8387172. 
• Nagao M, Hayashi H (2009). "Mixed lineage kinase 2 and hippocalcin are localized in Lewy bodies of Parkinson's disease". J. Neurol. Sci. 281 (1–2): 51–4. doi:10.1016/j.jns.2009.02.375. PMID 19332348. 
• Kobayashi M, Takamatsu K, Saitoh S et al. (1992). "Molecular cloning of hippocalcin, a novel calcium-binding protein of the recoverin family exclusively expressed in hippocampus". Biochem. Biophys. Res. Commun. 189 (1): 511–7. doi:10.1016/0006-291X(92)91587-G. PMID 1280427.  CS1 maint: Explicit use of et al. (link)
• Nagata K, Puls A, Futter C et al. (1998). "The MAP kinase kinase kinase MLK2 co-localizes with activated JNK along microtubules and associates with kinesin superfamily motor KIF3". EMBO J. 17 (1): 149–58. doi:10.1093/emboj/17.1.149. PMC 1170366. PMID 9427749.  CS1 maint: Explicit use of et al. (link)
• Kobayashi M, Takamatsu K, Saitoh S, Noguchi T (1993). "Myristoylation of hippocalcin is linked to its calcium-dependent membrane association properties". J. Biol. Chem. 268 (25): 18898–904. PMID 8360179. 
• Rudinskiy N, Kaneko YA, Beesen AA et al. (2009). "Diminished hippocalcin expression in Huntington's disease brain does not account for increased striatal neuron vulnerability as assessed in primary neurons". J. Neurochem. 111 (2): 460–72. doi:10.1111/j.1471-4159.2009.06344.x. PMID 19686238.  CS1 maint: Explicit use of et al. (link)
• Gerhard DS, Wagner L, Feingold EA et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.  CS1 maint: Explicit use of et al. (link)
• Strausberg RL, Feingold EA, Grouse LH et al. (2002). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.  CS1 maint: Explicit use of et al. (link)
• Mercer EA, Korhonen L, Skoglösa Y et al. (2000). "NAIP interacts with hippocalcin and protects neurons against calcium-induced cell death through caspase-3-dependent and -independent pathways". EMBO J. 19 (14): 3597–607. doi:10.1093/emboj/19.14.3597. PMC 313967. PMID 10899114.  CS1 maint: Explicit use of et al. (link)
• Ivings L, Pennington SR, Jenkins R et al. (2002). "Identification of Ca2+-dependent binding partners for the neuronal calcium sensor protein neurocalcin delta: interaction with actin, clathrin and tubulin". Biochem. J. 363 (Pt 3): 599–608. doi:10.1042/0264-6021:3630599. PMC 1222513. PMID 11964161.  CS1 maint: Explicit use of et al. (link)
• O'Callaghan DW, Haynes LP, Burgoyne RD (2005). "High-affinity interaction of the N-terminal myristoylation motif of the neuronal calcium sensor protein hippocalcin with phosphatidylinositol 4,5-bisphosphate". Biochem. J. 391 (Pt 2): 231–8. doi:10.1042/BJ20051001. PMC 1276920. PMID 16053445. 
• O'Callaghan DW, Ivings L, Weiss JL et al. (2002). "Differential use of myristoyl groups on neuronal calcium sensor proteins as a determinant of spatio-temporal aspects of Ca2+ signal transduction". J. Biol. Chem. 277 (16): 14227–37. doi:10.1074/jbc.M111750200. PMID 11836243.  CS1 maint: Explicit use of et al. (link)
• Markova 0, Fitzgerald D, Stepanyuk A et al. (2009). "Hippocalcin signaling via site-specific translocation in hippocampal neurons". Neurosci. Lett. 442 (2): 152–7. doi:10.1016/j.neulet.2008.06.089. PMC 2572729. PMID 18634855.  CS1 maint: Explicit use of et al. (link)

External links

• NCS proteins

English Journal

• Neuroprotective Properties of Cannabigerol in Huntington's Disease: Studies in R6/2 Mice and 3-Nitropropionate-lesioned Mice.

• Valdeolivas S1, Navarrete C, Cantarero I, Bellido ML, Muñoz E, Sagredo O.
• Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics.Neurotherapeutics.2015 Jan;12(1):185-99. doi: 10.1007/s13311-014-0304-z.
• Different plant-derived and synthetic cannabinoids have shown to be neuroprotective in experimental models of Huntington's disease (HD) through cannabinoid receptor-dependent and/or independent mechanisms. Herein, we studied the effects of cannabigerol (CBG), a nonpsychotropic phytocannabinoid, in 2
• PMID 25252936

• The EHEC-host interactome reveals novel targets for the translocated intimin receptor.

• Blasche S1, Arens S2, Ceol A3, Siszler G1, Schmidt MA4, Häuser R1, Schwarz F1, Wuchty S5, Aloy P6, Uetz P7, Stradal T8, Koegl M1.
• Scientific reports.Sci Rep.2014 Dec 18;4:7531. doi: 10.1038/srep07531.
• Enterohemorrhagic E. coli (EHEC) manipulate their human host through at least 39 effector proteins which hijack host processes through direct protein-protein interactions (PPIs). To identify their protein targets in the host cells, we performed yeast two-hybrid screens, allowing us to find 48 high-c
• PMID 25519916

• Estradiol alleviates the ischemic brain injury-induced decrease of neuronal calcium sensor protein hippocalcin.

• Koh PO1.
• Neuroscience letters.Neurosci Lett.2014 Oct 17;582:32-7. doi: 10.1016/j.neulet.2014.08.045. Epub 2014 Sep 3.
• Estradiol has protective and reparative effects in neurodegenerative diseases. Hippocalcin is a neuronal calcium-sensor protein that acts as a calcium buffer to regulate the intracellular concentration of Ca(2+). This study was investigated to elucidate whether estradiol regulates hippocalcin expres
• PMID 25192982

Japanese Journal

• ヒポカルシンによるmixed lineage kinase (MLK) 3活性の抑制

• 東邦医学会雑誌 55(2), 93-101, 2008-03
• NAID 40016022644

• Neuronal calcium sensor protein visinin-like protein-3 interacts with microsomal cytochrome b5 in a Ca2+-dependent manner.

• Journal of Biological Chemistry 279(15), 15142-15152, 2004-04
• NAID 120003161759

• 6. 記憶形成過程におけるカルシウム依存性遺伝子発現制御機構の解析(B.平成14年度プロジェクト研究報告,第57回 東邦医学会総会)

• 東邦醫學會雜誌 51(1), 49, 2004-01-01
• NAID 110004631633

Related Links

• Hippocalcin : Full Text : UCSD-Nature Molecule Pages

In the rat hippocampus, hippocalcin messenger RNA (mRNA) and immunoreactivity first appeared in the CA3 pyramidal cells on embryonic day 19 and postnatal day 1, respectively (Saitoh et al. 1994). At the same time, a high level of ...

• Hippocalcin

Hippocalcin. On-line free medical diagnosis assistant. Ranked list of possible diseases from either several symptoms or a full patient history. A similarity measure between symptoms and diseases is provided.