WordNet

in or to a high position, amount, or degree; "prices have gone up far too high"
a state of altered consciousness induced by alcohol or narcotics; "they took drugs to get a high on"
a state of sustained elation; "Im on a permanent high these days"
an air mass of higher than normal pressure; "the east coast benefits from a Bermuda high"
a lofty level or position or degree; "summer temperatures reached an all-time high"
a high place; "they stood on high and observed the countryside"; "he doesnt like heights" (同)heights
at a great altitude; "he climbed high on the ladder" (同)high up
used of sounds and voices; high in pitch or frequency (同)high-pitched
happy and excited and energetic (同)in high spirits
slightly and pleasantly intoxicated from alcohol or a drug (especially marijuana) (同)mellow
in a rich manner; "he lives high" (同)richly, luxuriously
(literal meaning) being at or having a relatively great or specific elevation or upward extension (sometimes used in combinations like `knee-high'
far up toward the source; "he lives high up the river"
greater than normal in degree or intensity or amount; "a high temperature"; "a high price"; "the high point of his career"; "high risks"; "has high hopes"; "the river is high"; "he has a high opinion of himself"
responsive to physical stimuli; "a mimosas leaves are sensitive to touch"; "a sensitive voltmeter"; "sensitive skin"; "sensitive to light"
hurting; "the tender spot on his jaw" (同)sore, raw, tender
being susceptible to the attitudes, feelings, or circumstances of others; "sensitive to the local community and its needs"
of or pertaining to classified information or matters affecting national security
a class of proteins produced in lymph tissue in vertebrates and that function as antibodies in the immune response (同)Ig, immune serum globulin, immune gamma globulin, immune_globulin

PrepTutorEJDIC

『高い』,高い所にある / 《数の後に置いて》高さが…ある / (数量・程度などが標準より)『高い』,大きい,激しい / (身分・地位が)『高い』,高貴な / 『気高い』,高潔な / (声の調子が)『高い』,鋭い / 値段の高い,金の掛かる,ぜいたくな / 楽しい,陽気な,上得意の / (時・季節が)盛りの,たけなわの / (色が)濃い,赤い / 《話》(酒・麻薬などに)酔って / 『高く』,高い所に / (価値・程度などが)高く,高度に,激しく / 〈C〉《話》高水準,高値 / 〈U〉(自動車の)高速ギア / 〈C〉《話》(麻薬などによる)酔った状態
(五感が)『敏感な』,感じやすい / 物事を非常に気にする,神経過敏な / 感光性の;(器械などが)感度のよい
《話》(あいさつとして)『やあ』,こんにちは / 《英》(注意を促す発声として)おい,ちょっと(hey)
einsteiniumの化学記号

UpToDate Contents

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1. IgEとアレルギー疾患の関係 the relationship between ige and allergic disease
2. IgEの生物学 the biology of ige
3. 常染色体優性型高IgE症候群 autosomal dominant hyperimmunoglobulin e syndrome
4. 抗IgE療法 anti ige therapy
5. 好酸球の生物学および好酸球増多症の原因 eosinophil biology and causes of eosinophilia

English Journal

Inhibitory effects of a cationic liposome on allergic reaction mediated by mast cell activation.

Inoh Y1, Tadokoro S, Tanabe H, Inoue M, Hirashima N, Nakanishi M, Furuno T.Author information 1School of Pharmacy, Aichi Gakuin University, 1-100 Kusumoto-cho, Chikusa-ku, Nagoya 464-8650, Japan. Electronic address: inoh@dpc.agu.ac.jp.AbstractSeveral studies have shown that cationic liposomes exert immunomodulatory effects with low immunogenicity and toxicity, and offer advantages such as easy preparation and targeting. Cationic liposomes not only transport DNA to immune cells but also enhance the function of antigen presenting cells such as dendritic cells and macrophages. Here, we investigated the effect of a particular cationic liposome on mast cell function during allergic reaction. We found that the cationic liposomes bound to the mast cell surface suppressed degranulation induced by cross-linking of high affinity immunoglobulin E receptors in a time- and dose-dependent manner. The suppression of degranulation was mediated by impairment of the sustained level of intracellular Ca(2+) concentration ([Ca(2+)]i) derived from the inhibition of store-operated Ca(2+) entry. The decrease in sustained elevation of [Ca(2+)]i led to the suppression of phosphorylation of soluble N-ethylmaleimide-sensitive factor attachment protein receptor proteins such as SNAP-23, syntaxin-4, which are necessary for membrane fusion between secretory granules and the plasma membrane during degranulation. Furthermore, the cationic liposomes suppressed vascular permeability elevation induced by mast cell activation in mice. These results showed that cationic liposomes possess the novel property of inhibiting mast cell activation, suggesting the possibility of developing cationic liposomes as anti-allergic effectors.
Biochemical pharmacology.Biochem Pharmacol.2013 Dec 15;86(12):1731-8. doi: 10.1016/j.bcp.2013.09.023. Epub 2013 Oct 5.
Several studies have shown that cationic liposomes exert immunomodulatory effects with low immunogenicity and toxicity, and offer advantages such as easy preparation and targeting. Cationic liposomes not only transport DNA to immune cells but also enhance the function of antigen presenting cells suc
PMID 24099793

Serum biomarkers in elderly asthma.

Rufo J1, Taborda-Barata L, Lourenço O.Author information 1CICS-UBI, Health Sciences Research Centre, University of Beira Interior , Covilhã , Portugal and.AbstractOBJECTIVE: Asthma is usually misdiagnosed and under-treated in the elderly population, resulting in complications and increased severity to the patient. In this review, we describe some of the most important serum markers of asthma studied so far, reporting their outcomes and possible prediction of asthma in the elderly population.
The Journal of asthma : official journal of the Association for the Care of Asthma.J Asthma.2013 Dec;50(10):1011-9. doi: 10.3109/02770903.2013.834932. Epub 2013 Oct 1.
OBJECTIVE: Asthma is usually misdiagnosed and under-treated in the elderly population, resulting in complications and increased severity to the patient. In this review, we describe some of the most important serum markers of asthma studied so far, reporting their outcomes and possible prediction of
PMID 23952480

Analysis of comorbidities and objective parameters in refractory chronic rhinosinusitis.

Batra PS1, Tong L, Citardi MJ.Author information 1Department of Otolaryngology-Head and Neck Surgery, University of Texas Southwestern Medical Center, Dallas, Texas.AbstractOBJECTIVES/HYPOTHESIS: The objective of this study was to construct the clinical profile of patients with chronic rhinosinusitis (CRS) with/without polyposis undergoing revision sinus surgery and to evaluate the relationship of polyposis, asthma, acetylsalicylic acid (aspirin) (ASA) sensitivity, inhalant allergies, and previous sinus surgery on disease severity as measured by objective parameters.
The Laryngoscope.Laryngoscope.2013 Dec;123 Suppl 7:S1-11. doi: 10.1002/lary.24418.
OBJECTIVES/HYPOTHESIS: The objective of this study was to construct the clinical profile of patients with chronic rhinosinusitis (CRS) with/without polyposis undergoing revision sinus surgery and to evaluate the relationship of polyposis, asthma, acetylsalicylic acid (aspirin) (ASA) sensitivity, inh
PMID 24122826

Japanese Journal

Establishment and characterization of mouse bone marrow-derived mast cell hybridomas

Kawahara Takeshi
EXPERIMENTAL CELL RESEARCH 318(18), 2385-2396, 2012-11
… In the present study, BMMCs were successfully immortalized by cell fusion using a hypoxanthine-aminopterin-thymidine medium-sensitive variant of P815 mouse mastocytoma (P815-6TgR) as a partner cell line. … The established mouse mast cell hybridomas (MMCHs) expressed alpha, beta, and gamma subunits of high-affinity immunoglobulin E (IgE) receptor (FcERI) and possessed cytoplasmic granules devoid of or partially filled with electron-dense material. …
NAID 120005312274

High-Frequency Electrodeless Quartz Crystal Microbalance Chip with a Bare Quartz Resonator Encapsulated in a Silicon Microchannel

Kato Fumihito,Ogi Hirotsugu,Yanagida Taiji [他],Nishikawa Shintaro,Nishiyama Masayoshi,Hirao Masahiko
Jpn J Appl Phys 50(7), 07HD03-07HD03-5, 2011-07-25
… We present a high-frequency electrodeless quartz crystal microbalance (QCM) chip with a bare quartz resonator encapsulated in a silicon microchannel, which is fabricated by micromachining technology. … As a result, a high quality factor (Q-factor) and a high signal-to-noise ratio (SNR) can be obtained. …
NAID 150000057626

Chlamydia pneumoniae Infection was Associated with Risk of Mortality from Coronary Heart Disease in Japanese Women but not Men: the JACC Study

Sakurai-Komada Naomi,A. Koike Kazuko,Kaku Yuuki,Hiraki Masaki,Cui Renzhe,Sankai Tomoko,Kikuchi Shogo,Date Chigusa,Tamakoshi Akiko,Iso Hiroyasu
Journal of Atherosclerosis and Thrombosis 17(5), 510-516, 2010
… Aim: To investigate the association between Chlamydia pneumoniae infection and mortality from coronary heart disease, a nested case-control study was conducted for 39,242 Japanese who participated in the JACC Study.<BR>Methods: Immunoglobulin A and G titers of C. …
NAID 130004845311

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