WordNet

in or to a high position, amount, or degree; "prices have gone up far too high"
a state of altered consciousness induced by alcohol or narcotics; "they took drugs to get a high on"
a state of sustained elation; "Im on a permanent high these days"
an air mass of higher than normal pressure; "the east coast benefits from a Bermuda high"
a lofty level or position or degree; "summer temperatures reached an all-time high"
a high place; "they stood on high and observed the countryside"; "he doesnt like heights" (同)heights
at a great altitude; "he climbed high on the ladder" (同)high up
used of sounds and voices; high in pitch or frequency (同)high-pitched
happy and excited and energetic (同)in high spirits
slightly and pleasantly intoxicated from alcohol or a drug (especially marijuana) (同)mellow
in a rich manner; "he lives high" (同)richly, luxuriously
(literal meaning) being at or having a relatively great or specific elevation or upward extension (sometimes used in combinations like `knee-high'
far up toward the source; "he lives high up the river"
greater than normal in degree or intensity or amount; "a high temperature"; "a high price"; "the high point of his career"; "high risks"; "has high hopes"; "the river is high"; "he has a high opinion of himself"
a natural attraction or feeling of kinship; "an affinity for politics"; "the mysterious affinity between them"; "Jamess affinity with Sam"
inherent resemblance between persons or things
the force attracting atoms to each other and binding them together in a molecule; "basic dyes have an affinity for wool and silk" (同)chemical attraction
a close connection marked by community of interests or similarity in nature or character; "found a natural affinity with the immigrants"; "felt a deep kinship with the other students"; "anthropologys kinship with the humanities" (同)kinship
(biology) state of relationship between organisms or groups of organisms resulting in resemblance in structure or structural parts; "in anatomical structure prehistoric man shows close affinity with modern humans" (同)phylogenetic relation
(anthropology) kinship by marriage or adoption; not a blood relationship
(immunology) the attraction between an antigen and an antibody

PrepTutorEJDIC

『高い』,高い所にある / 《数の後に置いて》高さが…ある / (数量・程度などが標準より)『高い』,大きい,激しい / (身分・地位が)『高い』,高貴な / 『気高い』,高潔な / (声の調子が)『高い』,鋭い / 値段の高い,金の掛かる,ぜいたくな / 楽しい,陽気な,上得意の / (時・季節が)盛りの,たけなわの / (色が)濃い,赤い / 《話》(酒・麻薬などに)酔って / 『高く』,高い所に / (価値・程度などが)高く,高度に,激しく / 〈C〉《話》高水準,高値 / 〈U〉(自動車の)高速ギア / 〈C〉《話》(麻薬などによる)酔った状態
〈C〉(人・物に対する)好み,親近感《+『for』(『to, with』)+『名』》 / 〈U〉〈C〉(2者の間の)密接な関係,類似《+『between』+『名』》;(…との)類縁《+『with』+『名』》 / 〈U〉〈C〉親和力(原子が化学反応を起こしやすい力)
《話》(あいさつとして)『やあ』,こんにちは / 《英》(注意を促す発声として)おい,ちょっと(hey)

UpToDate Contents

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1. ヘモグロビンの酸素親和性に関する遺伝性疾患 genetic disorders of hemoglobin oxygen affinity
2. IgEの生物学 the biology of ige
3. 肥満細胞：表面受容体とシグナル伝達 mast cells surface receptors and signal transduction
4. 体液性免疫応答 the humoral immune response
5. 先天性赤血球増多症および真性多血症の分子学的病因 molecular pathogenesis of congenital polycythemic disorders and polycythemia vera

English Journal

Characterization of glycation in an IgG1 by capillary electrophoresis sodium dodecyl sulfate and mass spectrometry.

Kaschak T, Boyd D, Yan B.SourceDepartment of Pharma Technical Development, Genentech, Oceanside, CA 92056, USA.
Analytical biochemistry.Anal Biochem.2011 Oct 15;417(2):256-63. Epub 2011 Jun 24.
We report a case study of characterization of a non-enzymatically glycated IgG1 using reducing capillary electrophoresis sodium dodecyl sulfate (CE-SDS) and mass spectrometry (MS). Glycation was found to occur nonspecifically at multiple sites in both the light and heavy chains. The glycated light a
PMID 21756870

Versatile bio-ink for covalent immobilization of chimeric avidin on sol-gel substrates.

Heikkinen JJ, Kivimaki L, Maatta JA, Makela I, Hakalahti L, Takkinen K, Kulomaa MS, Hytonen VP, Hormi OE.SourceDepartment of Chemistry, University of Oulu, P.O. Box 3000, FI-90014 Oulu, Finland.
Colloids and surfaces. B, Biointerfaces.Colloids Surf B Biointerfaces.2011 Oct 15;87(2):409-14. Epub 2011 Jun 6.
A bio-ink for covalent deposition of thermostable, high affinity biotin-binding chimeric avidin onto sol-gel substrates was developed. The bio-ink was prepared from heterobifunctional crosslinker 6-maleimidohexanoic acid N-hydroxysuccinimide which was first reacted either with 3-aminopropyltriethoxy
PMID 21705202

Japanese Journal

In-crystal affinity ranking of fragment hit compounds reveals a relationship with their inhibitory activities

Yamane Junji,Yao Min,Zhou Yong,Hiramatsu Yasuyuki,Fujiwara Kenichiro,Yamaguchi Tohru,Yamaguchi Hiroto,Togame Hiroko,Tsujishita Hideki,Takemoto Hiroshi,Tanaka Isao
Journal of Applied Crystallography 44(4), 798-804, 2011-08
… Although high-throughput protein crystallography is usually used to determine the protein-ligand complex structure and identify potential hit compounds, the relationship between the quality of the Fo-Fc maps of hit compounds and their inhibitory activities has rarely been examined. … Soaking experiments of all combinations of the five hit compounds were used to define the in-crystal affinity ranking. …
NAID 120003225996

cDNA cloning and bacterial expression of an endo-β-1,4-mannanase, AkMan, from Aplysia kurodai

Zahura Umme Afsari,Rahman Mohammad Matiur,Inoue Akira,Tanaka Hiroyuki,Ojima Takao
Comparative Biochemistry and Physiology Part B: Biochemistry and Molecular Biology 159(4), 227-235, 2011-08
… Previously we isolated an endo-β-1,4-mannanase (EC 3.2.1.78), AkMan, from the digestive fluid of a common sea hare Aplysia kurodai and demonstrated that this enzyme had a broad pH optimum spanning 4.0 to 7.5 and an appreciably high heat stability in this pH range (Zahura et al., Comp. … The recombinant AkMan (recAkMan) was expressed with an Escherichia coli BL21(DE3)-pCold1 expression system as an N-terminal hexahistidine-tagged protein and purified by Ni-NTA affinity chromatography. …
NAID 120003169051