ヘキシルカイン
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出典(authority):フリー百科事典『ウィキペディア(Wikipedia)』「2014/10/29 14:55:31」(JST)
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Hexylcaine
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Systematic (IUPAC) name |
1-cyclohexylaminopropan-2-yl benzoate |
Clinical data |
Legal status |
?
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Pharmacokinetic data |
Half-life |
<10 minutes |
Identifiers |
CAS number |
532-77-4 Y |
ATC code |
None |
PubChem |
CID 10770 |
DrugBank |
DB00473 |
ChemSpider |
10315 Y |
UNII |
511IU0826Z Y |
KEGG |
C14172 Y |
ChEMBL |
CHEMBL1197 Y |
Chemical data |
Formula |
C16H23NO2 |
Mol. mass |
261.359 g/mol |
SMILES
- O=C(OC(CNC1CCCCC1)C)c2ccccc2
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InChI
-
InChI=1S/C16H23NO2/c1-13(12-17-15-10-6-3-7-11-15)19-16(18)14-8-4-2-5-9-14/h2,4-5,8-9,13,15,17H,3,6-7,10-12H2,1H3 Y
Key:DKLKMKYDWHYZTD-UHFFFAOYSA-N Y
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Y (what is this?) (verify) |
Hexylcaine hydrochloride, also called cyclaine (Merck) or osmocaine, is a short-acting local anesthetic. It acts by inhibiting sodium channel conduction. Overdose can lead to headache, tinnitus, numbness and tingling around the mouth and tongue, convulsions, inability to breathe, and decreased heart function.
Synthesis
References
- ^ doi:10.1021/ja01237a010
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Anesthetics : Local anesthetics (primarily sodium channel blockers) (N01B)
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Esters by acid |
Aminobenzoic
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- Amylocaine
- Benzocaine
- Butacaine
- Butamben
- Chloroprocaine
- Dimethocaine
- Meprylcaine
- Metabutethamine
- Metabutoxycaine
- Orthocaine
- Propoxycaine
- Procaine (Novocaine)
- Proxymetacaine
- Risocaine
- Tetracaine
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Benzoic
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- 3-(p-Fluorobenzoyloxy)tropane
- Cocaine
- Cyclomethycaine
- Hexylcaine
- Isobucaine
- Piperocaine
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Amides |
- Articaine
- Bupivacaine # / Levobupivacaine / Ropivacaine
- Butanilicaine
- Carticaine
- Dibucaine
- Etidocaine
- Lidocaine #
- Mepivacaine
- Prilocaine
- Trimecaine
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Combinations |
- Anesthetic / anesthetic
- Lidocaine / prilocaine
- Anesthetic / vasoconstrictor
- Iontocaine
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- #WHO-EM
- ‡Withdrawn from market
- Clinical trials:
- †Phase III
- §Never to phase III
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anat (h / r / t / c / b / l / s / a)
- phys (r)
- devp
- prot
- nttm (nttr)
- ntrp
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- noco / auto / cong / tumr
- sysi / epon
- injr
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English Journal
- Comparison of local anesthetics as bronchodilator aerosols.
- Downes H, Hirshman CA, Leon DA.
- Anesthesiology.Anesthesiology.1983 Mar;58(3):216-20.
- Lidocaine aerosols have been ineffective at preventing airway constriction provoked by non-reflex stimuli. To determine if there were any advantages to using more potent amide-type local anesthetics or local anesthetics from other chemical classes, the authors compared the protection afforded by pre
- PMID 6829955
- A comparison in rat and mouse heart of the ability of several local anesthetics to inhibit monoamine oxidase.
- Dorris RL.
- Comparative biochemistry and physiology. C, Comparative pharmacology and toxicology.Comp Biochem Physiol C.1983;75(2):327-8.
- Several local anesthetics were examined and compared in rat and mouse heart for MAO inhibitory action. Procaine, chloroprocaine, procainamide and tetracaine were more potent in rat than mouse heart. Piperocaine, cyclomethycaine, hexylcaine and butacaine were somewhat more potent in mouse than rat he
- PMID 6138200
- Pharmacokinetics of the local anesthetic, hexylcaine hydrochloride, in man and the mouse.
- Rodgers RM, Dickinson RG, Lynn RK, Gerber N, Downes H, Loehning RW.
- Research communications in chemical pathology and pharmacology.Res Commun Chem Pathol Pharmacol.1980 Jul;29(1):99-112.
- PMID 7403681
Japanese Journal
- Hexylcaine「科薬」の歯科口腔外科領域への応用に関する研究
- 局所麻酔剤の微量分析法(III) : 脳脊髄液中の局所麻酔剤の分析法について
- 武田 寧,丹沢 珪子,星野 乙松,浮田 忠之進
- 衛生化学 12(3), 138-143, 1966-06-30
- … When hexylcaine, procaine and tetracaine were incubated with cerebro-spinal fluid, ester bonds of the compounds were hydrolysed mainly due to the increase of pH of cerebro-spinal fluid on standing, while amide bonds of dibucaine, lidocaine and carbocaine were unchanged. …
- NAID 110003655119
Related Links
- forum Join the Word of the Day Mailing List For webmasters TheFreeDictionary Google Bing? Word / Article Starts with Ends with Text ... hexylcaine [hek´sil-kān] a local anesthetic, used as the hydrochloride salt. hexylcaine a local ...
- Structured knowledge about Hexylcaine, which is a Molecular entity. Synonyms: Cyclaine, Hexilcaina (INN-Spanish), Hexylcaine hydrochloride, Hexylcainum (INN-Latin), Osmocaine. Date: 4-14-2014. ... Name: Hexylcaine Description:
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