WordNet

work natural fibers into a thread; "spin silk"
prolong or extend; "spin out a visit" (同)spin out
the act of rotating rapidly; "he gave the crank a spin"; "it broke off after much twisting" (同)twirl, twist, twisting, whirl
a distinctive interpretation (especially as used by politicians to sway public opinion); "the campaign put a favorable spin on the story"
a short drive in a car; "he took the new car for a spin"
a swift whirling motion (usually of a missile)
revolve quickly and repeatedly around ones own axis; "The dervishes whirl around and around without getting dizzy" (同)spin around, whirl, reel, gyrate
form a web by making a thread; "spiders spin a fine web"
make up a story; "spin a yarn"
stream in jets, of liquids; "The creek spun its course through the woods"
twist and turn so as to give an intended interpretation; "The Presidents spokesmen had to spin the story to make it less embarrassing"
of or relating to the spine or spinal cord; "spinal cord"; "spinal injury"
inability to coordinate voluntary muscle movements; unsteady movements and staggering gait (同)ataxy, dyssynergia, motor_ataxia

PrepTutorEJDIC

(羊毛などから)〈糸など〉‘を'『紡ぐ』《+『名』+『out of』+『名』〈羊毛〉》,(糸などに)〈羊毛など〉‘を'紡ぐ《+『名』〈羊毛〉+『into』+『名』》 / 〈クモ・カイコなどが〉〈糸〉‘を'『吐く』;〈巣・繭〉‘を'かける / …‘を'くるくる回す / 〈物語など〉‘を'作る,話す / 『糸を紡ぐ』;〈クモ・カイコなどが〉糸を吐く / 〈こまなどが〉くるくる回る / 〈車などが〉疾走する / 〈頭などが〉くらくらする / 〈C〉〈U〉くるくる回すこと;回転 / 〈C〉《単数形で》(車などの)一走り / 〈C〉(飛行機の)きりもみ降下 / 〈C〉《単数形で》(価値などの)急落
背骨の / せき髄麻酔
世襲の,親譲りの / 遺伝的な,遺伝性の

UpToDate Contents

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1. 遺伝性運動失調の概要 overview of the hereditary ataxias
2. 急性運動失調を呈する小児に対するアプローチ approach to the child with acute ataxia
3. 脊髄に影響を与える疾患 disorders affecting the spinal cord
4. フリードライヒ失調症 friedreich ataxia
5. 馬尾症候群などの腫瘍による硬膜外脊髄圧迫の臨床的特徴および診断 clinical features and diagnosis of neoplastic epidural spinal cord compression including cauda equina syndrome

English Journal

Decreased functional brain activation in Friedreich ataxia using the Simon effect task.

Georgiou-Karistianis N, Akhlaghi H, Corben LA, Delatycki MB, Storey E, Bradshaw JL, Egan GF.SourceExperimental Neuropsychology Research Unit, School of Psychology and Psychiatry, Monash University, Clayton 3800, Victoria, Australia. nellie.georgiou-karistianis@monash.edu
Brain and cognition.Brain Cogn.2012 Aug;79(3):200-8. Epub 2012 Apr 28.
The present study applied the Simon effect task to examine the pattern of functional brain reorganization in individuals with Friedreich ataxia (FRDA), using functional magnetic resonance imaging (fMRI). Thirteen individuals with FRDA and 14 age and sex matched controls participated, and were requir
PMID 22542844

Childhood Ataxia: Clinical Features, Pathogenesis, Key Unanswered Questions, and Future Directions.

Ashley CN, Hoang KD, Lynch DR, Perlman SL, Maria BL.AbstractChildhood ataxia is characterized by impaired balance and coordination primarily because of cerebellar dysfunction. Friedreich ataxia, a form of childhood ataxia, is the most common multisystem autosomal recessive disease. Most of these patients are homozygous for the GAA repeat expansion located on the first intron of the frataxin gene on chromosome 9. Mutations in the frataxin gene impair mitochondrial function, increase reactive oxygen species, and trigger redistribution of iron in the mitochondria and cytosol. Targeted therapies for Friedreich ataxia are undergoing testing. In addition, a centralized database, patient registry, and natural history study have been launched to support clinical trials in Friedreich ataxia. The 2011 Neurobiology of Disease in Children symposium, held in conjunction with the 40th annual Child Neurology Society meeting, aimed to (1) describe clinical features surrounding Friedreich ataxia, including cardiomyopathy and genetics; (2) discuss recent advances in the understanding of the pathogenesis of Friedreich ataxia and developments of clinical trials; (3) review new investigations of characteristic symptoms; and (4) establish clinical and biochemical overlaps in neurodegenerative diseases and possible directions for future basic, translational, and clinical studies.
Journal of child neurology.J Child Neurol.2012 Aug 1. [Epub ahead of print]
Childhood ataxia is characterized by impaired balance and coordination primarily because of cerebellar dysfunction. Friedreich ataxia, a form of childhood ataxia, is the most common multisystem autosomal recessive disease. Most of these patients are homozygous for the GAA repeat expansion located on
PMID 22859693