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出典(authority):フリー百科事典『ウィキペディア(Wikipedia)』「2014/05/28 23:38:11」(JST)

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  • Involvement of oxidative stress and mitochondrial/lysosomal cross-talk in olanzapine cytotoxicity in freshly isolated rat hepatocytes.
  • Eftekhari A1,2,3,4, Azarmi Y2,3, Parvizpur A2,3, Eghbal MA2,3.
  • Xenobiotica; the fate of foreign compounds in biological systems.Xenobiotica.2016 Apr;46(4):369-78. doi: 10.3109/00498254.2015.1078522. Epub 2015 Sep 12.
  • 1. Olanzapine (OLZ) is a widely used atypical antipsychotic agent for the treatment of schizophrenia and other disorders. Serious hepatotoxicity and elevated liver enzymes have been reported in patients receiving OLZ. However, the cellular and molecular mechanisms of the OLZ hepatotoxicity are unk
  • PMID 26364812
  • Inflammatory MAPK and NF-κB signaling pathways differentiated hepatitis potential of two agglomerated titanium dioxide particles.
  • Chen J1, Zhang J2, Cao J3, Xia Z4, Gan J5.
  • Journal of hazardous materials.J Hazard Mater.2016 Mar 5;304:370-8. doi: 10.1016/j.jhazmat.2015.11.002. Epub 2015 Nov 10.
  • TiO2 nanoparticles (TiO2NPs) consumption and deposit in liver have possible implications for hepatitis risks. Specific signal dysregulation at early inflammatory responses needs to be characterized in TiO2NP-induced hepatopathy. MAPK and NF-κB signaling pathways are known to participate in inflamma
  • PMID 26590873
  • Observation of hepatotoxicity during long-term gefitinib administration in patients with non-small-cell lung cancer.
  • Wang J1, Wu Y, Dong M, He X, Wang Z, Li J, Wang Y.
  • Anti-cancer drugs.Anticancer Drugs.2016 Mar;27(3):245-50. doi: 10.1097/CAD.0000000000000323.
  • To observe drug-induced hepatotoxicity by long-term gefitinib administration in the treatment of non-small-cell lung cancer. The data of 101 patients with locally advanced or metastatic non-small-cell lung cancer, for which gefitinib had been used orally for 3 months or longer, were retrospectively
  • PMID 26633888


  • Increase in covalent binding of 5-hydroxydiclofenac to hepatic tissues in rats co-treated with lipopolysaccharide and diclofenac : involvement in the onset of diclofenac-induced idiosyncratic hepatotoxicity
  • Kishida Tomoyuki,Onozato Tomoya,Kanazawa Toru [他]
  • The Journal of toxicological sciences 37(6), 1143-1156, 2012-12-00
  • NAID 40019523864
  • Enhancement of acetaminophen-induced chronic hepatotoxicity in restricted fed rats : a nonclinical approach to acetaminophen-induced chronic hepatotoxicity in susceptible patients
  • Kondo Kazuma,Yamada Naohito,Suzuki Yusuke [他],TOYODA Kaoru,HASHIMOTO Tatsuji,TAKAHASHI Akemi,KOBAYASHI Akio,SHODA Toshiyuki,KUNO Hideyuki,SUGAI Shoichiro
  • Journal of toxicological sciences 37(5), 911-929, 2012-10-01
  • NAID 10030876240
  • 非小細胞肺癌患者のゲフィチニブによる肝機能障害に対するプロヘパール^【○!R】錠の有効性
  • 糸谷 涼,竹村 昌也,井上 大生 [他],高松 和史,石床 学,鈴木 進子,松本 正孝,櫻本 稔,福井 基成
  • 日本呼吸器学会誌 = Annals of the Japanese Respiratory Society 1(5), 369-373, 2012-07-10
  • NAID 10030794211


hep·a·to·tox·ic·i·ty (hep'ă-tō-tok-sis'i-tē), The capacity of a drug, chemical, or other exposure to produce injury to the liver. Agents with recognized hepatotoxicity include carbon tetrachloride, alcohol, dantrolene sodium, valproic acid ...
Hepatotoxicity information including symptoms, diagnosis, misdiagnosis, treatment, causes, patient stories, videos, forums, prevention, and prognosis. ... Hepatotoxicity: Introduction Hepatotoxicity: Damage or injury to the liver ...


 Home > SIGs Home > HepatotoxicityClinical trials for Hepatotoxicity are What it is and where it isNRF2 signaling hepatotoxicity assay 4the catalyst acetaminophen (APAP) hepatotoxicity




  • 肝毒性の

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「toxic to the liver」








1マーフィー徴候 18
2narrow segment 16
3" wounds are made"  15
4グレイ症候群 15
5"phenoxypolyethoxylethanol" 15
6ロイシンエンケファリン 13
7硝酸ミコナゾール 11
8Common Laboratory Equipment 11
9content 10
10だいすいたいしんけい 9
11粟粒結核と肉下種 9
12全身性ヒマン細胞小 9
13細胞内寄生菌 9
14kligler培地 原理 9
15不整脈  9
16角膜反射 中枢 9
17膜性骨化 8
18ソルデム 8
19ハプロ不全 疾患 8
20日本多毛 8

1" wounds are made"  15
2kligler培地 原理 9
3kligler培地 硫化鉄 4
4ǸCαꥦ륹ΤǤ뤳ȤŦƤ֤Ƥ 4
5歳の女性。右目の疼痛、充血および霧視を主訴に来院した。眼底に異常を認めない。視力は右 0.9 (矯正不能)、左 1.2 (矯正不能)。眼圧は右 11 mmHg、左 12 mmHg。フルオレセイン染色後の前眼部写真 (別冊No. 5) を別に示す。 治療薬として適切なのはどれか。 4
6胃癌 borrmann分類 3
7回復過程 3
8ジェンドラシック法 メカニズム 3
9しょうすいたいしんけい 3
10ラリンゲルマスク ゼリー 3
11ハッセルバッハ三角 3
12白内障 grade 3
13フォンギールケ病 3
14マッコーネルサイン 3
15小児骨折 好発部位 3
16咽頭神経叢 3
17低アルドステロン症 3
18フロマン徴候 3
19オーグメンチン 販売中止 3
20クスマウル徴候 3