- 関
- hepatic damage、hepatocellular injury、liver cell damage、liver damage
WordNet
- suffer or be susceptible to damage; "These fine china cups damage easily"
- inflict damage upon; "The snow damaged the roof"; "She damaged the car when she hit the tree"
- the act of damaging something or someone (同)harm, hurt, scathe
- loss of military equipment (同)equipment casualty
- the occurrence of a change for the worse (同)harm, impairment
- designed or tending to discredit, especially without positive or helpful suggestions; "negative criticism" (同)negative
- (sometimes followed by `to' (同)detrimental, prejudicial, prejudicious
- harmed or injured or spoiled; "I wont buy damaged goods"; "the storm left a wake of badly damaged buildings"
- a sum of money paid in compensation for loss or injury (同)amends, indemnity, indemnification, restitution, redress
PrepTutorEJDIC
- 〈U〉『損害』,損傷,被害 / 《複数形で》損害賠障[金] / 《the~》《単数形で》《話》飛用 / …‘に'損傷する
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English Journal
- Dietary modulation of the biotransformation and genotoxicity of aflatoxin B(1).
- Gross-Steinmeyer K, Eaton DL.SourceCenter for Ecogenetics and Environmental Health, Department of Environmental and Occupational Health Sciences, University of Washington, Seattle, WA, United States.
- Toxicology.Toxicology.2012 Sep 28;299(2-3):69-79. Epub 2012 May 26.
- Diet and its various components are consistently identified as among the most important 'risk factors' for cancer worldwide, yet great uncertainty remains regarding the relative contribution of nutritive (e.g., vitamins, calories) vs. non-nutritive (e.g., phytochemicals, fiber, contaminants) factors
- PMID 22640941
- FXR ligands protect against hepatocellular inflammation via SOCS3 induction.
- Xu Z, Huang G, Gong W, Zhou P, Zhao Y, Zhang Y, Zeng Y, Gao M, Pan Z, He F.AbstractBecause of the anti-inflammatory actions of farnesoid X receptor (FXR) agonists, FXR has received much attention as a potential therapeutic target. However, the molecular mechanisms of actions have not yet been elucidated. In the present study, we reported that in the animal model of LPS-induced liver injury, administration of the FXR natural ligand CDCA could attenuate hepatocyte inflammatory damage, reduce transaminase activities, suppress inflammation mediators (IL-6, TNF-α and ICAM-1) expression and inhibit STAT3 phosphorylation. These protective effects of FXR were accompanied by an increased expression of suppressor of cytokine signaling 3 (SOCS3), which is a negative feedback regulator of cytokine-STAT3 signaling. We then demonstrated that the beneficial effects of FXR agonist in STAT3 activation were weakened by small interfering RNA-mediated SOCS3 knockdown in hepacytes. Moreover we observed both natural ligand CDCA and synthetic ligand GW4064 could upregulate SOCS 3 expression by enhancing the promoter activity in hepatocytes. These results suggest modulation of SOCS3 expression may represent a novel mechanism through which FXR activation could selectively affect cytokine bioactivity in inflammation response. FXR ligands may be potentially therapeutic in the treatment of liver inflammatory diseases via SOCS3 induction.
- Cellular signalling.Cell Signal.2012 Aug;24(8):1658-64. Epub 2012 Apr 25.
- Because of the anti-inflammatory actions of farnesoid X receptor (FXR) agonists, FXR has received much attention as a potential therapeutic target. However, the molecular mechanisms of actions have not yet been elucidated. In the present study, we reported that in the animal model of LPS-induced liv
- PMID 22560881
Japanese Journal
- The role of NF-κB in PARP-inhibitor-mediated sensitization and detoxification of arsenic trioxide in hepatocellular carcinoma cells
- , , ,
- The Journal of Toxicological Sciences 40(3), 349-363, 2015
- … In this study, we investigated ATO sensitization and detoxification effect of the Poly (ADP ribose) polymerase-1 (PARP-1) inhibitor 4-Amino-1,8-naphthalimide (4AN) in the hepatocellular carcinoma cell line HepG2. … We also demonstrated that the ATO-induced activation of PARP-1 and NF-κB was closely associated with the oxidative DNA damage mediated by the generated reactive oxygen species (ROS). …
- NAID 130005068414
- 化学物質のリスク評価における肝肥大の取扱いの基本的考え方
- 吉田 緑,梅村 隆志,小島 弘幸,井上 薫,高橋 美和,浦丸 直人,北村 繁幸,安部 賀央里,頭金 正博,小澤 正吾,吉成 浩一
- 食品衛生学雑誌 56(2), 42-48, 2015
- 化学物質で一般的に誘発される肝肥大が生体の適応反応か，毒性(悪影響)かを判断するための科学的な考え方を提示した．外的因子に対して肝細胞の恒常性が維持されている範囲内の肝肥大(肝細胞肥大および肝重量増加)は，適応性変化であり毒性影響ではない．同時に生体の恒常性保持機能の限界を越し，破綻を来した場合の肝細胞肥大は毒性と判断すべきである．具体的には以下の変化を伴う肝肥大は毒性影響の可能性を考える起点にな …
- NAID 130005067294
- 肝疾患に発症した胃前庭部毛細血管拡張症に対するアルゴンプラズマ凝固療法と内視鏡的結紮術
- 佐藤 隆啓,山崎 克,赤池 淳
- 日本消化器内視鏡学会雑誌 57(2), 185-192, 2015
- 【背景，目的】肝疾患に認められた胃前庭部毛細血管拡張症（GAVE）の臨床的特徴と内視鏡治療の有用性について検討した．<BR>【方法】34例の特徴的な内視鏡所見を示したGAVEを対象とした．アルゴンプラズマ凝固療法（APC）を34例中22例に，内視鏡的結紮術（EBL）を12例に施行した．<BR>【結果】34例全例に鉄欠乏性貧血を認めこのうち，21例に黒色便が観察された．基礎疾 …
- NAID 130004811863
Related Links
- Hepatocellular Damage and Drugs | View Drugs and Medication Side Effect Reports associated with Hepatocellular Damage ... Have You experienced Hepatocellular Damage? What is HEPATOCELLULAR DAMAGE? All medicines ...
- Answer (1 of 3): Hepatocellular damage occurs when Hepatocyte cells are affected in the liver. These cells make up 70 to 80 per cent of the cytoplasmic mass of the liver. Cytoplasm is a thick liquid which exists between the cell ...
★リンクテーブル★
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- 関
- hepatic damage、hepatic dysfunction、hepatocellular damage、hepatocellular injury、hepatopathy、liver cell damage、liver disorder
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- 関
- hepatic dysfunction、hepatocellular damage、hepatocellular injury、hepatopathy、liver cell damage、liver damage、liver disorder
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- 英
- hepatocellular injury、hepatocellular damage、liver damage、hepatic damage、liver cell damage
- 関
- 肝障害
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- 関
- hepatic damage、hepatocellular damage、hepatocellular injury、liver damage
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- 関
- hepatic damage、hepatocellular damage、liver cell damage、liver damage
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- 関
- barrier、break、breakage、difficulty、disorder、disruption、disturbance、dysfunction、foe、hindrance、impair、impairment、impediment、injure、injury、lesion、obstacle、spoilage
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- 関
- hepatic cell、hepatic parenchymal cell、hepatocyte、hepatocytic、liver cell
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- 関
- affective、injurious、traumatic