hepatocarcinogenicity

English Journal

Dose- and time-dependent epigenetic changes in the livers of fisher 344 rats exposed to furan.

Conti Ad1, Kobets T, Escudero-Lourdes C, Montgomery B, Tryndyak V, Beland FA, Doerge DR, Pogribny IP.
Toxicological sciences : an official journal of the Society of Toxicology.Toxicol Sci.2014 Jun;139(2):371-80. doi: 10.1093/toxsci/kfu044. Epub 2014 Mar 10.
The presence of furan in common cooked foods along with evidence from experimental studies that lifetime exposure to furan causes liver tumors in rats and mice has caused concern to regulatory public health agencies worldwide; however, the mechanisms of the furan-induced hepatocarcinogenicity remain
PMID 24614236

In Vivo Genotoxicity of Ginkgo Biloba Extract in gpt Delta Mice and Constitutive Androstane Receptor Knockout Mice.

Maeda J1, Kijima A2, Inoue K2, Ishii Y2, Ichimura R2, Takasu S2, Kuroda K2, Matsushita K2, Kodama Y3, Saito N4, Umemura T2, Yoshida M2.
Toxicological sciences : an official journal of the Society of Toxicology.Toxicol Sci.2014 May 13. pii: kfu090. [Epub ahead of print]
The National Toxicology Program study of Ginkgo biloba extract (GBE), a herbal supplement, reported concerns regarding genotoxicity and clear evidence of hepatocarcinogenicity and liver hypertrophy in mice. To clarify the genotoxicity of GBE in vivo, we performed reporter gene mutation assay using g
PMID 24824808

The effects of mixtures of dichloroacetate and trichloroacetate on induction of oxidative stress in livers of mice after subchronic exposure.

Hassoun E1, Cearfoss J, Mamada S, Al-Hassan N, Brown M, Heimberger K, Liu MC.
Journal of toxicology and environmental health. Part A.J Toxicol Environ Health A.2014;77(6):313-23. doi: 10.1080/15287394.2013.864576.
Dichloroacetate (DCA) and trichloroacetate (TCA) are drinking-water chlorination by-products previously found to induce oxidative stress (OS) in hepatic tissues of B6C3F1 male mice. To assess the effects of mixtures of the compounds on OS, groups of male B6C3F1 mice were treated daily by gavage with
PMID 24593144

Lack of Hepatocarcinogenicity of Combinations of Low Doses of 2-amino-3, 8-dimethylimidazo[4,5-f]quinoxaline and Diethylnitrosamine in Rats: Indication for the Existence of a Threshold for Genotoxic Carcinogens

Wei Min,Kakehashi Anna,Yamano Shotaro,Tamano Seiko,Shirai Tomoyuki,Wanibuchi Hideki,Fukushima Shoji
Journal of Toxicologic Pathology 25(3), 209-214, 2012
… The purposes of the present study were to evaluate the hepatocarcinogenicity of concurrent treatment of 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline (MeIQx) and diethylnitrosamine (DEN) in rats and to determine whether no effect levels of combinations of these two different structural categories of genotoxic hepatocarcinogens exist. …
NAID 130001884610

Modulatory Effects of Capsaicin on N-diethylnitrosamine (DEN)-induced Mutagenesis in Salmonella typhimurium YG7108 and DEN-induced Hepatocarcinogenesis in gpt Delta Transgenic Rats

TOYODA HOKAIWADO Naomi,YASUI Yumiko,TAKAMUNE Makiko,YAMADA Masami,MURAMATSU Mina,MASUMURA Kenichi,OHTA Toshihiro,TANAKA Takuji,NOHMI Takehiko
Genes and environment : the official journal of the Japanese Environmental Mutagen Society 33(4), 160-166, 2011-11-20
NAID 10029977480

Enhanced hepatocarcinogenicity by combined inhalation and oral exposures to N,N-dimethylformamide in male rats

Ohbayashi Hisao,Umeda Yumi,Senoh Hideki,Kasai Tatsuya,Kano Hirokazu,Nagano Kasuke,Arito Heihachiro,Fukushima Shoji
Journal of toxicological sciences 34(1), 53-63, 2009-02-01
N,N-Dimethylformamide (DMF), a ubiquitous contaminant in living and working environments, enters the human body by inhalation, as well as by oral and dermal routes of exposure. In order to provide bio …
NAID 110007043239