WordNet

a harmful or corrupting agency; "bigotry is a virus that must not be allowed to spread"; "the virus of jealousy is latent in everyone"
(virology) ultramicroscopic infectious agent that replicates itself only within cells of living hosts; many are pathogenic; a piece of nucleic acid (DNA or RNA) wrapped in a thin coat of protein
a software program capable of reproducing itself and usually capable of causing great harm to files or other programs on the same computer; "a true virus cannot spread to another computer without human assistance" (同)computer virus
the 2nd letter of the Roman alphabet (同)b
the blood group whose red cells carry the B antigen (同)type_B, group B
any of a large group of nitrogenous organic compounds that are essential constituents of living cells; consist of polymers of amino acids; essential in the diet of animals for growth and for repair of tissues; can be obtained from meat and eggs and milk and legumes; "a diet high in protein"
the 16th letter of the Roman alphabet (同)p
inflammation of the liver caused by a virus or a toxin

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TGF-β suppression of HBV RNA through AID-dependent recruitment of an RNA exosome complex.

Liang G1, Liu G2, Kitamura K2, Wang Z3, Chowdhury S2, Monjurul AM2, Wakae K2, Koura M2, Shimadu M2, Kinoshita K4, Muramatsu M2.
PLoS pathogens.PLoS Pathog.2015 Apr 2;11(4):e1004780. doi: 10.1371/journal.ppat.1004780. eCollection 2015.
Transforming growth factor (TGF)-β inhibits hepatitis B virus (HBV) replication although the intracellular effectors involved are not determined. Here, we report that reduction of HBV transcripts by TGF-β is dependent on AID expression, which significantly decreases both HBV transcripts and viral
PMID 25836330

Bordon Y.
Nature reviews. Immunology.Nat Rev Immunol.2015 Feb;15(2):70-1. doi: 10.1038/nri3810. Epub 2015 Jan 19.
RIG-I induces a type III interferon response during hepatitis B virus infection and also directly interferes with viral replication.
PMID 25598531

The RNA sensor RIG-I dually functions as an innate sensor and direct antiviral factor for hepatitis B virus.

Sato S1, Li K1, Kameyama T1, Hayashi T2, Ishida Y3, Murakami S4, Watanabe T4, Iijima S4, Sakurai Y5, Watashi K6, Tsutsumi S4, Sato Y5, Akita H5, Wakita T6, Rice CM7, Harashima H5, Kohara M8, Tanaka Y4, Takaoka A9.
Immunity.Immunity.2015 Jan 20;42(1):123-32. doi: 10.1016/j.immuni.2014.12.016. Epub 2014 Dec 18.
Host innate recognition triggers key immune responses for viral elimination. The sensing mechanism of hepatitis B virus (HBV), a DNA virus, and the subsequent downstream signaling events remain to be fully clarified. Here we found that type III but not type I interferons are predominantly induced in
PMID 25557055

TGF-β Suppression of HBV RNA through AID-Dependent Recruitment of an RNA Exosome Complex

Liang Guoxin,Liu Guangyan,Kitamura Kouichi,Wang Zhe,Chowdhury Sajeda,Md Monjurul Ahasan,Wakae Kousho,Koura Miki,Shimadu Miyuki,Kinoshita Kazuo,Muramatsu Masamichi
PLoS Pathogens 11(4), e1004780, 2015-04-01
… Transforming growth factor (TGF)-β inhibits hepatitis B virus (HBV) replication although the intracellular effectors involved are not determined. … Immunoprecipitation reveals that AID physically associates with viral P protein that binds to specific virus RNA sequence called epsilon. … AID also binds to an RNA degradation complex (RNA exosome proteins), indicating that AID, RNA exosome, and P protein form an RNP complex. …
NAID 120005646683

High copy numbers and N terminal insertion position of influenza A M2E fused with hepatitis B core antigen enhanced immunogenicity

Sun Xincheng,Wang Yunlong,Dong Caiwen,Hu Jinqiang,Yang Liping
BioScience Trends 9(4), 221-227, 2015
… The extra domain of influenza M2 protein (M2e) is almost completely conserved among all influenza A virus subtypes. … In this study, we designed and created different constructs through genetic fusion of M2e (MSLLTEVETPTRSEWECRCSDSSD) (A/California/05/2009 (H1N1)) with the N-terminus (HBcAg1−149aa+Cys) by insertion in the N-terminus Hepatitis B Core (HBc) antigen 1−149aa and Middle 78-81aa of HBcAg1-149aa to construct a recombinant M2e-based vaccine candidate. …
NAID 130005098735

N-Linked Glycosylation at an Appropriate Position in the Pre-S2 Domain Is Critical for Cellular and Humoral Immunity against Middle HBV Surface Antigen

Liu Hao,Wang Shixia,Jia Yiqiong,Li Jun,Huang Zuhu,Lu Shan,Xing Yiping
The Tohoku Journal of Experimental Medicine 236(2), 131-138, 2015
… Infection with hepatitis B virus (HBV) remains a worldwide health problem, and DNA-based vaccines against HBV have been tested for therapeutic applications. … One mutant protein contains Q at position 4 (MQWQSTTFHQ). … Moreover, the MHBs protein that carries a N-linked glycosylation site at position 5 or 7 retained the properties similar to wild-type MHBs. …
NAID 130005075697