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English Journal

Cancer cell glycocalyx mediates mechanotransduction and flow-regulated invasion.

Qazi H, Palomino R, Shi ZD, Munn LL, Tarbell JM.SourceDepartment of Biomedical Engineering, The City College of New York/CUNY, The City University of New York, Steinman Hall, T-404C, Convent Avenue at 140th Street, New York, NY 10031, USA. tarbell@ccny.cuny.edu.
Integrative biology : quantitative biosciences from nano to macro.Integr Biol (Camb).2013 Nov 21;5(11):1334-43. doi: 10.1039/c3ib40057c. Epub 2013 Sep 30.
Mammalian cells are covered by a surface proteoglycan (glycocalyx) layer, and it is known that blood vessel-lining endothelial cells use the glycocalyx to sense and transduce the shearing forces of blood flow into intracellular signals. Tumor cells in vivo are exposed to forces from interstitial flu
PMID 24077103

Serum-free culture of rat proximal tubule cells with enhanced function on chitosan.

Chang SH, Chiang IN, Chen YH, Young TH.SourceInstitute of Biomedical Engineering, College of Medicine and College of Engineering, National Taiwan University, Taipei, Taiwan.
Acta biomaterialia.Acta Biomater.2013 Nov;9(11):8942-51. doi: 10.1016/j.actbio.2013.06.032. Epub 2013 Jun 29.
The proximal tubule performs a variety of important renal functions and is the major site for nutrient reabsorption. The purpose of this study is to culture rat renal proximal tubule cells (PTCs) on chitosan without serum to maintain a transcellular pathway to transport water and ions effectively wi
PMID 23816651

In vitro and ex vivo evaluation of a multi-epitope heparinase vaccine for various malignancies.

Tang XD, Guo SL, Wang GZ, Li N, Wu YY, Fang DC, Fan YH, Yang SM.SourceDepartment of Gastroenterology, Xinqiao Hospital, Third Military Medical University, Chongqing, 400037, P.R. China.
Cancer science.Cancer Sci.2013 Oct 24. doi: 10.1111/cas.12308. [Epub ahead of print]
Previous studies have indicated that heparanase may represent a candidate universal tumor-associated antigen (TAA). However, vaccine therapy targeting only one cytotoxic T lymphocyte CTL epitope is suboptimal in preventing cancer. In this study, we designed heparanase multi-epitope vaccines to incre
PMID 24152338

Study on the Sliding Friction of Endothelial Cells Cultured on Hydrogel and the Role of Glycocalyx on Friction Reduction

Chen Yong Mei,Kurokawa Takayuki,Tominaga Taiki,Yasuda Kazunori,Osada Yoshihito,Gong Jian Ping,Yamamoto Kimiko,Ando Joji
Advanced Engineering Materials 12(11), B628-B636, 2010-11-17
… Three sets of HUVEC monolayers were investigated: 1) as-cultured HUVEC monolayer, 2) HUVEC monolayer treated by transforming growth factor υ1 (TGF-υ1), which increased glycocalyx by 148%, 3) HUVEC monolayer treated by heparinase I, which reduced glycocalyx by 57%, both were compared with that of the as prepared one. … When being slid on flat glass surface, the frictional stress of HUVEC monolayer decreased in the order of heparinase I-treated > …
NAID 120002741677