関: heparinase

WordNet

a polysaccharide produced in basophils (especially in the lung and liver) and that inhibits the activity of thrombin in coagulation of the blood; it (trade names Lipo-Hepin and Liquaemin) is used as an anticoagulant in the treatment of thrombosis and in heart surgery (同)Lipo-Hepin, Liquaemin

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ヘバリン(肝臓などにあり血液の凝固を防ぐ物質)

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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2019/07/20 14:06:08」(JST)

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In enzymology, a heparin lyase (EC 4.2.2.7) is an enzyme that catalyzes the chemical reaction

Eliminative cleavage of polysaccharides containing 1,4-linked D-glucuronate or L-iduronate residues and 1,4-alpha-linked 2-sulfoamino-2-deoxy-6-sulfo-D-glucose residues to give oligosaccharides with terminal 4-deoxy-alpha-D-gluc-4-enuronosyl groups at their non-reducing ends

This enzyme belongs to the family of lyases, specifically those carbon-oxygen lyases acting on polysaccharides. The systematic name of this enzyme class is heparin lyase. Other names in common use include heparin eliminase, and heparinase.

References

Hovingh P, Linker A (1970). "The enzymatic degradation of heparin and heparitin sulfate. 3 Purification of a heparitinase and a heparinase from flavobacteria". J. Biol. Chem. 245 (22): 6170–5. PMID 5484472.

This EC 4.2 enzyme-related article is a stub. You can help Wikipedia by expanding it.

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1. ヘパリンおよびLMWヘパリン：用量および副作用 heparin and lmw heparin dosing and adverse effects
2. ヘパリン起因性血小板減少症のマネージメント management of heparin induced thrombocytopenia
3. 静脈血栓塞栓症に対する低分子ヘパリン low molecular weight heparin for venous thromboembolic disease
4. ヘパリン起因性血小板減少症の臨床症状および診断 clinical presentation and diagnosis of heparin induced thrombocytopenia
5. 妊娠中および出産後の抗凝固薬の利用 use of anticoagulants during pregnancy and postpartum

English Journal

On the catalytic mechanism of polysaccharide lyases: evidence of His and Tyr involvement in heparin lysis by heparinase I and the role of Ca2+

Córdula CR, Lima MA, Shinjo SK, Gesteira TF, Pol-Fachin L, Coulson-Thomas VJ, Verli H, Yates EA, Rudd TR, Pinhal MA, Toma L, Dietrich CP, Nader HB, Tersariol IL.SourceDisciplina de Biologia Molecular, Departamento de Bioquímica, Universidade Federal de São Paulo, Escola Paulista de Medicina, Rua Três de Maio, 100, CEP 04044-020, São Paulo, SP, Brazil. hbnader.bioq@epm.br ivarne@umc.br.
Molecular bioSystems.Mol Biosyst.2013 Nov 15. [Epub ahead of print]
The structurally diverse polysaccharide lyase enzymes are distributed from plants to animals but share common catalytic mechanisms. One, heparinase I (F. heparinum), is employed in the production of the major anticoagulant drug, low molecular weight heparin, and is a mainstay of cell surface proteog
PMID 24232366

Quantitation of heparosan with heparin lyase III and spectrophotometry.

Huang H, Zhao Y, Lv S, Zhong W, Zhang F, Linhardt RJ.SourceCollege of Biological and Environmental Engineering, Zhejiang University of Technology, Hangzhou, 310032, PR China.
Analytical biochemistry.Anal Biochem.2013 Oct 30. pii: S0003-2697(13)00509-5. doi: 10.1016/j.ab.2013.10.029. [Epub ahead of print]
Heparosan is Escherichia coli K5 capsule polysaccharide, which is the key precursor for preparing bioengineered heparin. A rapid and effective quantitative method for detecting heparosan is important in the large-scale production of heparosan. Heparin lyase III effectively catalyzes the heparosan de
PMID 24184357

Peptide p5 binds both heparinase-sensitive glycosaminoglycans and fibrils in patient-derived AL amyloid extracts.

Martin EB, Williams A, Heidel E, Macy S, Kennel SJ, Wall JS.SourceDepartment of Medicine, University of Tennessee Graduate School of Medicine, 1924 Alcoa Highway, Knoxville, TN 37922, USA.
Biochemical and biophysical research communications.Biochem Biophys Res Commun.2013 Jun 21;436(1):85-9. doi: 10.1016/j.bbrc.2013.05.063. Epub 2013 May 23.
In previously published work, we have described heparin-binding synthetic peptides that preferentially recognize amyloid deposits in a mouse model of reactive systemic (AA) amyloidosis and can be imaged by using positron and single photon emission tomographic imaging. We wanted to extend these findi
PMID 23707811

Japanese Journal

A Surface Loop in the N-Terminal Domain of Pedobacter heparinus Heparin Lyase II is Important for Activity

Journal of Applied Glycoscience advpub(0), 2015
NAID 130005100638

Purification and Characterization of a Novel Heparinase from Bacteroides stercoris HJ-15.

The Journal of Biochemistry 128(2), 323-328, 2000
NAID 130003533949

Characterization of Heparinase from an Oral Bacterium Prevotella heparinolytica^1

The journal of biochemistry 123(2), 283-288, 1998-02-01
NAID 10005841756

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リンク元	「heparinase」「ヘパリンリアーゼ」

「heparinase」

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heparin lyase
Identifiers
EC number	4.2.2.7
CAS number	9025-39-2
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Gene Ontology	AmiGO / QuickGO
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ヘパリナーゼ、ヘパリン分解酵素

関: heparin lyase

「ヘパリンリアーゼ」

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英: heparin lyase
関: ヘパリナーゼ

v t e Carbon–oxygen lyases (EC 4.2) (primarily dehydratases)
4.2.1: Hydro-Lyases	Carbonic anhydrase Fumarase Aconitase Enolase Alpha Enolase 2 Enoyl-CoA hydratase/3-Hydroxyacyl ACP dehydrase Methylglutaconyl-CoA hydratase Tryptophan synthase Cystathionine beta synthase Porphobilinogen synthase 3-Isopropylmalate dehydratase Urocanase Uroporphyrinogen III synthase Nitrile hydratase
4.2.2: Acting on polysaccharides	Hyaluronate lyase
4.2.3: Acting on phosphates	Threonine synthase
4.2.99: Other	Carboxymethyloxysuccinate lyase Hydroperoxide lyase

v t e Enzymes
Activity	Active site Binding site Catalytic triad Oxyanion hole Enzyme promiscuity Catalytically perfect enzyme Coenzyme Cofactor Enzyme catalysis
Regulation	Allosteric regulation Cooperativity Enzyme inhibitor Enzyme activator
Classification	EC number Enzyme superfamily Enzyme family List of enzymes
Kinetics	Enzyme kinetics Eadie–Hofstee diagram Hanes–Woolf plot Lineweaver–Burk plot Michaelis–Menten kinetics
Types	EC1 Oxidoreductases (list) EC2 Transferases (list) EC3 Hydrolases (list) EC4 Lyases (list) EC5 Isomerases (list) EC6 Ligases (list) EC7 Translocases (list)

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heparin lyase