ヘマト・ルフィリン
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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2012/05/25 17:20:04」(JST)
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Hematoporphyrin
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| Systematic (IUPAC) name |
| 7,12-bis(1-hydroxyethyl)-3,8,13,17-tetramethyl-21H,23H-porphine-2,18-dipropanoic acid |
| Clinical data |
| Pregnancy cat. |
? |
| Legal status |
℞ Prescription only |
| Routes |
Oral |
| Identifiers |
| CAS number |
14459-29-1 |
| ATC code |
None |
| PubChem |
CID 11103 |
| ChemSpider |
10632 Y |
| UNII |
HBT6M5H379 Y |
| ChEMBL |
CHEMBL317840 Y |
| Chemical data |
| Formula |
C34H38N4O6 |
| Mol. mass |
598.69 g/mol |
| SMILES |
eMolecules & PubChem |
InChI
-
InChI=1S/C34H38N4O6/c1-15-21(7-9-31(41)42)27-14-28-22(8-10-32(43)44)16(2)24(36-28)12-29-34(20(6)40)18(4)26(38-29)13-30-33(19(5)39)17(3)25(37-30)11-23(15)35-27/h11-14,19-20,37-40H,7-10H2,1-6H3,(H,41,42)(H,43,44)/b23-11-,24-12-,25-11-,26-13-,27-14-,28-14-,29-12-,30-13- Y
Key:KFKRXESVMDBTNQ-AMPAVEGJSA-N Y
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Y (what is this?) (verify)
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Hematoporphyrin (Photodyn, Sensibion) is an endogenous porphyrin formed by the acid hydrolysis of hemoglobin. Nencki and Zaleski determined its chemical structure in 1900.[1]
Hematoporphyrin has been used as an antidepressant and antipsychotic since the 1920s.[2][3]
See also
References
- ^ "SpringerLink - Journal Article". http://www.springerlink.com/content/r6116jm001tx1210/.
- ^ O'Neil, Maryadele J. (2001). The Merck index: an encyclopedia of chemicals, drugs, and biologicals. Rahway, NJ: Merck Research Laboratories. ISBN 0-911910-13-1.
- ^ "HEMATOPORPHYRIN AS A THERAPEUTIC AGENT IN THE PSYCHOSES -- Strecker et al. 90 (6): 1157 -- Am J Psychiatry". http://ajp.psychiatryonline.org/cgi/content/abstract/90/6/1157.
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Antidepressants (N06A)
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Specific reuptake inhibitors (RIs), enhancers (REs), and releasing agents (RAs)
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Selective serotonin reuptake inhibitors (SSRIs)
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- Alaproclate
- Citalopram
- Escitalopram
- Femoxetine
- Fluoxetine#
- Fluvoxamine
- Indalpine
- Ifoxetine
- Litoxetine
- Lubazodone
- Omiloxetine
- Panuramine
- Paroxetine
- Pirandamine
- Seproxetine
- Sertraline#
- Zimelidine‡
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Serotonin–norepinephrine reuptake inhibitors (SNRIs)
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- Clovoxamine
- Desvenlafaxine
- Duloxetine
- Levomilnacipran
- Eclanamine
- Milnacipran
- Sibutramine
- Venlafaxine
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Serotonin–norepinephrine–dopamine reuptake inhibitors (SNDRIs)
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- Amitifadine
- Bicifadine
- Brasofensine
- BTS-74,398
- Cocaine
- Diclofensine
- DOV-21,947
- DOV-102,677
- DOV-216,303
- EXP-561
- Fezolamine
- JNJ-7925476
- NS-2359
- PRC200-SS
- Pridefine
- SEP-225,289
- SEP-227,162
- Tesofensine
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Norepinephrine reuptake inhibitors (NRIs)
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- Amedalin
- Atomoxetine/Tomoxetine
- Binedaline
- Ciclazindol
- Daledalin
- Edivoxetine
- Esreboxetine
- Lortalamine
- Mazindol
- Nisoxetine
- Reboxetine
- Talopram
- Talsupram
- Tandamine
- Viloxazine
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Dopamine reuptake inhibitors (DRIs)
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Norepinephrine-dopamine reuptake inhibitors (NDRIs)
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- Amineptine
- Bupropion/Amfebutamone#
- Cilobamine
- Manifaxine
- Methylphenidate
- Nomifensine
- Radafaxine
- Tametraline
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Norepinephrine-dopamine releasing agents (NDRAs)
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- Amphetamine
- Befuraline
- Lisdexamfetamine
- Methamphetamine
- Phenethylamine
- Piberaline
- Tranylcypromine
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Serotonin-norepinephrine-dopamine releasing agents (SNDRAs)
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- 4-Methyl-αMT
- αET/Etryptamine
- αMT/Metryptamine
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Selective serotonin reuptake enhancers (SSREs)
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Others
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- Indeloxazine
- Teniloxazine
- Tramadol
- Viqualine
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Receptor antagonists and/or reuptake inhibitors
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Serotonin antagonists and reuptake inhibitors (SARIs)
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- Etoperidone
- Nefazodone
- Trazodone
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Noradrenergic and specific serotonergic antidepressants (NaSSAs)
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- Aptazapine
- Esmirtazapine
- Mianserin
- Mirtazapine
- Setiptiline/Teciptiline
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Norepinephrine-dopamine disinhibitors (NDDIs)
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Serotonin modulators and stimulators (SMSs)
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Others
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Heterocyclic antidepressants (bi-, tri-, and tetracyclics)
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Bicyclics
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Tricyclics
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- Amezepine
- Amineptine
- Amitriptyline#
- Amitriptylinoxide
- Azepindole
- Butriptyline
- Cianopramine
- Clomipramine
- Cotriptyline
- Cyanodothiepin
- Demexiptiline
- Depramine/Balipramine
- Desipramine
- Dibenzepin
- Dimetacrine
- Dosulepin/Dothiepin
- Doxepin
- Enprazepine
- Fluotracen
- Hepzidine
- Homopipramol
- Imipramine
- Imipraminoxide
- Intriptyline
- Iprindole
- Ketipramine
- Litracen
- Lofepramine
- Losindole
- Mariptiline
- Melitracen
- Metapramine
- Mezepine
- Naranol
- Nitroxazepine
- Nortriptyline
- Noxiptiline
- Octriptyline
- Opipramol
- Pipofezine
- Propizepine
- Protriptyline
- Quinupramine
- Tampramine
- Tianeptine
- Tienopramine
- Trimipramine
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Tetracyclics
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- Amoxapine
- Aptazapine
- Azipramine
- Ciclazindol
- Ciclopramine
- Esmirtazapine
- Maprotiline
- Mazindol
- Mianserin
- Mirtazapine
- Oxaprotiline
- Setiptiline/Teciptiline
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Monoamine oxidase inhibitors (MAOIs)
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Nonselective
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- Irreversible: Benmoxin
- Carbenzide
- Cimemoxin
- Domoxin
- Echinopsidine
- Iproclozide
- Iproniazid
- Isocarboxazid
- Mebanazine
- Metfendrazine
- Nialamide
- Octamoxin
- Phenelzine
- Pheniprazine
- Phenoxypropazine
- Pivalylbenzhydrazine
- Safrazine
- Tranylcypromine
- Reversible: Caroxazone
- Paraxazone
- Quercetin
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MAOA-Selective
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- Reversible: Amiflamine
- Bazinaprine
- Befloxatone
- Befol
- Berberine
- Brofaromine
- Cimoxatone
- Esuprone
- Harmala Alkaloids (Harmine
- Harmaline
- Tetrahydroharmine
- Harman
- Norharman, etc)
- Methylene Blue
- Metralindole
- Minaprine
- Moclobemide
- Pirlindole
- Sercloremine
- Tetrindole
- Toloxatone
- Tyrima
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MAOB-Selective
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- Irreversible: Ladostigil
- Mofegiline
- Pargyline
- Rasagiline
- Selegiline
- Reversible: Lazabemide
- Milacemide
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Azapirones and other 5-HT1A receptor agonists
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- Alnespirone
- Aripiprazole
- Befiradol
- Buspirone
- Eptapirone
- Flesinoxan
- Flibanserin
- Gepirone
- Ipsapirone
- Oxaflozane
- Tandospirone
- Vilazodone
- Zalospirone
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- #WHO-EM
- ‡Withdrawn from market
- Clinical trials:
- †Phase III
- §Never to phase III
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dsrd (o, p, m, p, a, d, s), sysi/epon, spvo
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proc(eval/thrp), drug(N5A/5B/5C/6A/6B/6D)
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Antipsychotics (neuroleptics) (N05A)
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| Typical |
- Benzamides
- Levosulpiride
- Nemonapride
- Sulpiride
- Sultopride
- Tiapride
- Veralipride
- Butyrophenones
- Azaperone
- Benperidol
- Bromperidol
- Droperidol
- Fluanisone
- Haloperidol
- Lenperone
- Moperone
- Pipamperone
- Spiperone
- Timiperone
- Trifluperidol
- Diphenylbutylpiperidines
- Clopimozide
- Fluspirilene
- Penfluridol
- Pimozide
- Phenothiazines
- Acepromazine
- Acetophenazine
- Butaperazine
- Carphenazine
- Chloracizine
- Chlorproethazine
- Chlorpromazine
- Cyamemazine
- Dixyrazine
- Fluacizine
- Fluphenazine
- Levomepromazine/Methotrimeprazine
- Mesoridazine
- Perazine
- Pericyazine
- Perphenazine
- Piperacetazine
- Pipotiazine
- Prochlorperazine
- Promazine
- Promethazine
- Propiomazine
- Sulforidazine
- Thiethylperazine
- Thiopropazate
- Thioproperazine
- Thioridazine
- Trifluoperazine
- Triflupromazine
- Thioxanthenes
- Chlorprothixene
- Clopenthixol
- Flupentixol
- Thiothixene
- Zuclopenthixol
- Tricyclics
- Amoxapine
- Butaclamol
- Fluotracen
- Loxapine
- Trimipramine
- Others
- Prothipendyl
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| Atypical |
- Benzamides
- Amisulpride
- Remoxipride
- Butyrophenones
- Cinuperone
- Setoperone
- Benzo(iso)oxazolepiperidines
- Iloperidone
- Ocaperidone
- Paliperidone
- Risperidone
Benzo(iso)thiazolepiperazines: Lurasidone
- Perospirone
- Revospirone
- Tiospirone
- Ziprasidone
- Diphenylbutylpiperazines
- Amperozide
- Phenylpiperazines
- Aripiprazole
- Bifeprunox
- Brexpiprazole
- Elopiprazole
- Umespirone
- Tricyclics
- Asenapine
- Carpipramine
- Clocapramine
- Clorotepine
- Clotiapine
- Clozapine
- Fluperlapine
- Gevotroline
- Metitepine
- Mosapramine
- NDMC
- Olanzapine
- Piquindone
- Quetiapine
- Tenilapine
- Zotepine
- Others
- Blonanserin
- Cariprazine
- Molindone
- Pimavanserin
- Roxindole
- Sarizotan
- Sertindole
- Spiramide
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| Others |
- Azacyclonol
- Cannabidiol
- D-Cycloserine
- Lithium
- Mazapertine§
- Mifepristone
- Oxypertine
- Reserpine
- Rimcazole
- Secretin
- Talnetant
- Tetrabenazine
- Vabicaserin
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- #WHO-EM
- ‡Withdrawn from market
- Clinical trials:
- †Phase III
- §Never to phase III
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dsrd (o, p, m, p, a, d, s), sysi/epon, spvo
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proc(eval/thrp), drug(N5A/5B/5C/6A/6B/6D)
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UpToDate Contents
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English Journal
- In vitro study of low intensity ultrasound combined with different doses of PDT: Effects on C6 glioma cells.
- Li JH, Chen ZQ, Huang Z, Zhan Q, Ren FB, Liu JY, Yue W, Wang Z.SourceDepartment of Neurosurgery, The Fourth College Hospital of Harbin Medical University, Harbin, P.R. China ;
- Oncology letters.Oncol Lett.2013 Feb;5(2):702-706. Epub 2012 Dec 4.
- The aim of this study was to study the effects of killing C6 glioma cells induced by hematoporphyrin monomethyl ether (HMME)-mediated sonodynamic therapy combined with photodynamic therapy (SPDT). In the SPDT group, the cells were treated with sonication at an intensity of 0.5 W/cm(2) and a frequenc
- PMID 23420417
- Feasibility study on quantitative measurements of singlet oxygen generation using singlet oxygen sensor green.
- Lin H, Shen Y, Chen D, Lin L, Wilson BC, Li B, Xie S.SourceKey Laboratory of OptoElectronic Science and Technology for Medicine of Ministry of Education, Fujian Provincial Key Laboratory for Photonics Technology, Fujian Normal University, Fujian, 350007, China.
- Journal of fluorescence.J Fluoresc.2013 Jan;23(1):41-7. doi: 10.1007/s10895-012-1114-5. Epub 2012 Aug 23.
- The purpose of this study is to investigate the feasibility for quantitative measurement of singlet oxygen ((1)O(2)) generation by using a newly developed (1)O(2)-specific fluorescence probe Singlet Oxygen Sensor Green reagent (SOSG). (1)O(2) generation from photoirradiation of a model photosensitiz
- PMID 22914972
Japanese Journal
- Hematoporphyrin derivative-mediated photodynamic therapy inhibits tumor growth in human cholangiocarcinoma in vitro and in vivo
- CAO Liang-qi,XUE Ping,LU Hai-wu,ZHENG Qiang,WEN Zi-long,SHAO Zhi-jian
- Hepatology research : the official journal of the Japan Society of Hepatology 39(12), 1190-1197, 2009-12-01
- NAID 10027405988
- SUVITHA A.,BELOSLUDOV R. V.,水関 博志,川添 良幸,武田 元博,河野 雅弘,大内 憲明
- 日本金屬學會誌 73(8), 555-558, 2009-08-01
- NAID 10025156759
Related Links
- Hematoporphyrin (Photodyn, Sensibion) is an endogenous porphyrin formed by the acid hydrolysis of hemoglobin. Nencki and Zaleski determined its ... Hematoporphyrin has been used as an antidepressant and antipsychotic since the 1920s.
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