hematologic disorder

血液病

関

blood disease、haematological disease、hematological disease

WordNet

1. bring disorder to (同)disarray
2. a physical condition in which there is a disturbance of normal functioning; "the doctor prescribed some medicine for the disorder"; "everyone gets stomach upsets from time to time" (同)upset
3. a disturbance of the peace or of public order
4. of or relating to or involved in hematology (同)haematological, hematological
5. not arranged in order (同)unordered

PrepTutorEJDIC

1. 〈U〉『無秩序』,混乱,乱雑(confusion) / 《しばしば複数形で》(社会的・政治的な)粉争,騒動 / 〈C〉(肉体的・精神的な)不調,異常,障害 / …‘の'秩序を乱す / 〈心身〉‘に'異常を起こさせる

Wikipedia preview

出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2017/09/28 19:26:55」(JST)

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Hematologic disease
Classification and external resources
Specialty	hematology
MeSH	D006402

Hematologic diseases are disorders which primarily affect the blood. Hematology includes the study of these disorders.

Myeloid

• Hemoglobinopathies (congenital abnormality of the hemoglobin molecule or of the rate of hemoglobin synthesis)
  • Sickle-cell disease
  • Thalassemia
  • Methemoglobinemia
• Anemias (lack of red blood cells or hemoglobin)
  • Iron deficiency anemia
  • Megaloblastic anemia
    • Vitamin B₁₂ deficiency
      • Pernicious anemia
    • Folate deficiency
  • Hemolytic anemias (destruction of red blood cells)
    • Genetic disorders of RBC membrane
      • Hereditary spherocytosis
      • Hereditary elliptocytosis
      • Congenital dyserythropoietic anemia
    • Genetic disorders of RBC metabolism
      • Glucose-6-phosphate dehydrogenase deficiency (G6PD)
      • Pyruvate kinase deficiency
    • Immune mediated hemolytic anemia (direct Coombs test is positive)
      • Autoimmune hemolytic anemia
        • Warm antibody autoimmune hemolytic anemia
          • Idiopathic
          • Systemic lupus erythematosus (SLE)
          • Evans' syndrome (antiplatelet antibodies and hemolytic antibodies)
        • Cold autoimmune hemolytic anemia
          • Cold agglutinin disease
          • Paroxysmal cold hemoglobinuria (rare)
          • Infectious mononucleosis
      • Alloimmune hemolytic anemia
        • Hemolytic disease of the newborn (HDN)
          • Rh disease (Rh D)
          • ABO hemolytic disease of the newborn
          • Anti-Kell hemolytic disease of the newborn
          • Rhesus c hemolytic disease of the newborn
          • Rhesus E hemolytic disease of the newborn
          • Other blood group incompatibility (RhC, Rhe, Kid, Duffy, MN, P and others)
      • Drug induced immune mediated hemolytic anemia
        • Penicillin (high dose)
        • Methyldopa
    • Hemoglobinopathies (where these is an unstable or crystalline hemoglobin)
    • Paroxysmal nocturnal hemoglobinuria (rare acquired clonal disorder of red blood cell surface proteins)
    • Direct physical damage to RBCs
      • Microangiopathic hemolytic anemia
      • Secondary to artificial heart valve(s)
  • Aplastic anemia
    • Fanconi anemia
    • Diamond-Blackfan anemia (inherited pure red cell aplasia)
    • Acquired pure red cell aplasia
• Decreased numbers of cells
  • Myelodysplastic syndrome
  • Myelofibrosis
  • Neutropenia (decrease in the number of neutrophils)
  • Agranulocytosis
  • Glanzmann's thrombasthenia
  • Thrombocytopenia (decrease in the number of platelets)
    • Idiopathic thrombocytopenic purpura (ITP)
    • Thrombotic thrombocytopenic purpura (TTP)
    • Heparin-induced thrombocytopenia (HIT)
• Myeloproliferative disorders (Increased numbers of cells)
  • Polycythemia vera (increase in the number of cells in general)
  • Erythrocytosis (increase in the number of red blood cells)
  • Leukocytosis (increase in the number of white blood cells)
  • Thrombocytosis (increase in the number of platelets)
  • Myeloproliferative disorder
• Coagulopathies (disorders of bleeding and coagulation)
  • Thrombocytosis
  • Recurrent thrombosis
  • Disseminated intravascular coagulation
  • Disorders of clotting proteins
    • Hemophilia
      • Hemophilia A
      • Hemophilia B (also known as Christmas disease)
      • Hemophilia C
    • Von Willebrand disease
    • Disseminated intravascular coagulation
    • Protein S deficiency
    • Antiphospholipid syndrome
  • Disorders of platelets
    • Thrombocytopenia
    • Glanzmann's thrombasthenia
    • Wiskott-Aldrich syndrome

Hematological malignancies

• Hematological malignancies
  • Lymphomas
    • Hodgkin's disease
    • Non-Hodgkin's lymphoma {includes the next five entries}
      • Burkitt's lymphoma
      • Anaplastic large cell lymphoma
      • Splenic marginal zone lymphoma
      • Hepatosplenic T-cell lymphoma
      • Angioimmunoblastic T-cell lymphoma (AILT)
  • Myelomas
    • Multiple myeloma
    • Waldenström macroglobulinemia
    • Plasmacytoma
  • Leukemias increased WBC
    • Acute lymphocytic leukemia (ALL)
    • Chronic lymphocytic leukemia (CLL){now included in theCLL/SCLL type NHL}
    • Acute myelogenous leukemia (AML)
    • Chronic Idiopathic Myelofibrosis (MF)
    • Chronic myelogenous leukemia (CML)
    • T-cell prolymphocytic leukemia (T-PLL)
    • B-cell prolymphocytic leukemia (B-PLL)
    • Chronic neutrophilic leukemia (CNL)
    • Hairy cell leukemia (HCL)
    • T-cell large granular lymphocyte leukemia (T-LGL)
    • Aggressive NK-cell leukemia

Miscellaneous

• Hemochromatosis
• Asplenia
• Hypersplenism
  • Gaucher's disease
• Monoclonal gammopathy of undetermined significance
• Hemophagocytic lymphohistiocytosis
• Tempi syndrome

Hematological changes secondary to non-hematological disorders

• Anemia of chronic disease
• Infectious mononucleosis
• AIDS
• Malaria
• Leishmaniasis

External links

• http://www.hematologic.niddk.nih.gov/info/index.htm
• Myeloproliferative Disorders (MPD) Foundation and Research Alliance
• International Registry of Rare Bleeding Disorders

UpToDate Contents

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• 1. アルコール乱用と血液疾患 alcohol abuse and hematologic disorders
• 2. 貧血を有する成人患者に対するアプローチ approach to the adult patient with anemia
• 3. 血液悪性腫瘍を有する成人における侵襲性真菌感染症予防 prophylaxis of invasive fungal infections in adults with hematologic malignancies
• 4. 壊疽性膿皮症：病因、臨床症状、および診断 pyoderma gangrenosum pathogenesis clinical features and diagnosis
• 5. 壊疽性膿皮症：治療および予後 pyoderma gangrenosum treatment and prognosis

English Journal

• Renal involvement in Waldenström's macroglobulinemia: case report and review of literature.

• Salviani C, Guido G, Serriello I, Giannakakis K, Rocca AR.SourceNephrology and Dialysis A Unit, "Sapienza" University of Rome , Italy and.
• Renal failure.Ren Fail.2014 Feb;36(1):114-8. doi: 10.3109/0886022X.2013.832859. Epub 2013 Sep 24.
• Abstract Waldenström's macroglobulinemia (WM) is a rare lymphoid neoplasia, accounting for 2% of all hematological malignancies. Renal complications occur rather rarely compared to multiple myeloma. The most common renal manifestations are mild proteinuria and microhematuria. We describe a case of
• PMID 24059636

• The added value of propensity score matching when using health-related quality of life reference data.

• Cottone F, Efficace F, Apolone G, Collins GS.SourceItalian Group for Adult Hematologic Diseases (GIMEMA) Data Center and Health Outcomes Research Unit, Rome, Italy.
• Statistics in medicine.Stat Med.2013 Dec 20;32(29):5119-32. doi: 10.1002/sim.5868. Epub 2013 Jun 5.
• Direct comparisons of health-related quality of life (HRQoL) outcomes between non-randomized groups might be biased, as outcomes are confounded by imbalance in pre-treatment patient characteristics. Such bias can be reduced by adjusting on observed covariates. This is the setting of HRQoL comparison
• PMID 23740803

• Complement factor H related proteins (CFHRs).

• Skerka C, Chen Q, Fremeaux-Bacchi V, Roumenina LT.SourceDepartment of Infection Biology, Leibniz Institute for Natural Product Research and Infection Biology, Jena, Germany. christine.skerka@hki-jena.de
• Molecular immunology.Mol Immunol.2013 Dec 15;56(3):170-80. doi: 10.1016/j.molimm.2013.06.001. Epub 2013 Jul 3.
• Factor H related proteins comprise a group of five plasma proteins: CFHR1, CFHR2, CFHR3, CFHR4 and CFHR5, and each member of this group binds to the central complement component C3b. Mutations, genetic deletions, duplications or rearrangements in the individual CFHR genes are associated with a numbe
• PMID 23830046

Japanese Journal

• A novel interplay between the Fanconi anemia core complex and ATR-ATRIP kinase during DNA cross-link repair.

• Tomida Junya,Itaya Akiko,Shigechi Tomoko,Unno Junya,Uchida Emi,Ikura Masae,Masuda Yuji,Matsuda Shun,Adachi Jun,Kobayashi Masahiko,Meetei Amom Ruhikanta,Maehara Yoshihiko,Yamamoto Ken-Ichi,Kamiya Kenji,Matsuura Akira,Matsuda Tomonari,Ikura Tsuyoshi,Ishiai Masamichi,Takata Minoru
• Nucleic acids research 41(14), 6930-6941, 2013-08-01
• … The Fanconi anemia (FA) pathway is also activated following genomic stress, and defects in this pathway cause a cancer-prone hematologic disorder in humans. …
• NAID 120005323036

• 再メチル化障害により退行を示しベタイン食療法が効果を示した1例

• 島田 姿野,舟塚 真,中陣 瑠美 [他],平野 嘉子,伊藤 進,吉井 啓介,石垣 景子,大澤 真木子
• 東京女子医科大学雑誌 83(E1), E307-E312, 2013-01-31
• メチオニン、ホモシステインはDNAメチル化において重要な働きを担い、メチル基転移反応の中心的な役割を担う。脳は遺伝子の厳密な調整を必要とする臓器でありDNAメチル化により遺伝子発現調節を行う。故にメチル基転移機構の異常はしばしば重篤な神経疾患を引き起こしうる。今回、アミノ酸代謝異常による再メチル化障害により急激な退行を来たし、ベタイン食事療法により神経症状の改善を認めた一例につき報告した。症例は9 …
• NAID 110009559396

• 胆囊摘出術後腹部ドレーン出血を契機に診断された先天性血友病Bの1例

• 川本 潤,三浦 世樹,深田 忠臣,林 達也
• 日本消化器外科学会雑誌 46(9), 662-668, 2013
• 　術後出血を契機に診断された血友病Bの1例を経験したので報告する．症例は70歳の男性で，胆囊結石症の診断で腹腔鏡下胆囊摘出術を行った．術後に胆囊床部ドレーンから凝血塊を伴わない出血を認め，凝固異常症を疑い，新鮮凍結血漿製剤（frozen fresh plasma；FFP）を緊急投与した．腹部CTで腹腔内に貯留液は認めず，ドレーン挿入部皮下筋層からの出血と診断して局所麻酔下に止血処置を行った．後日第 …
• NAID 130004560968

Related Links

• Hematologic disease - Wikipedia, the free encyclopedia

Hematologic diseases are disorders which primarily affect the blood. Contents. 1 Myeloid; 2 Hematological malignancies; 3 Miscellaneous; 4 Hematological changes secondary to non-hematological disorders; 5 External links. [edit] Myeloid ...

• Blood Disorders - American Society of Hematology

Why Should I Know About Blood Conditions? When something is wrong with your blood, it can affect your total health. That is why it is important for you to know about some of the common blood disorders that may affect you. People may be ...

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★リンクテーブル★

リンク元	「blood disease」「血液病」「hematological disease」「haematological disease」
関連記事	「disorder」「hematologic」

「blood disease」

　　[★]

• 血液病、血液疾患

関

blood disorder、blood dyscrasia、haematological disease、haematological disorder、hematologic disease、hematologic disorder、hematological disease、hematological disorder、hemopathy

「血液病」

　　[★]

英

hematologic disorder、hematological disease、haematological disease、blood disease

関

血液疾患

「hematological disease」

　　[★]

• 血液病

関

blood disease、haematological disease、hematologic disease、hematologic disorder

「haematological disease」

　　[★]

血液病

関

blood disease、hematologic disorder、hematological disease

「disorder」

　　[★]

• 障害：個人的苦痛や機能の障害があるので「疾病」とは言えるものの、その背景にある臓器障害がもう一つはっきりしない場合に用いられる。(PSY.9)

• n.

• an untidy state; a lack of order or organization (⇔order)
• violent behaviour of large groups of people
• an illness that cause a part of the body to stop functioning correctly

• 注意

disease <> illness <> disorder

• vt.

• 乱す、乱雑にする。(人)の(心身の)調子を狂わせる。

• vi.

　 　 　 　

「hematologic」

　　[★]

• 血液学的な

関

haematologic、haematological、haematologically、hematological、hematologically