English Journal

DNA damage-induced Lok/CHK2 activation compromises germline stem cell self-renewal and lineage differentiation.

Ma X1,2, Han Y1, Song X1, Do T1, Yang Z3, Ni J3, Xie T4,2.
Development (Cambridge, England).Development.2016 Dec 1;143(23):4312-4323. Epub 2016 Oct 11.
Stem cells in adult tissues are constantly exposed to genotoxic stress and also accumulate DNA damage with age. However, it remains largely unknown how DNA damage affects both stem cell self-renewal and differentiation. In this study, we show that DNA damage retards germline stem cell (GSC) self-ren
PMID 27729408

Serebryannyy LA1, Yuen M2, Parilla M1, Cooper ST2, de Lanerolle P1.
Frontiers in physiology.Front Physiol.2016 Oct 7;7:454. eCollection 2016.
Actin plays a crucial role in regulating multiple processes within the nucleus, including transcription and chromatin organization. However, the polymerization state of nuclear actin remains controversial, and there is no evidence for persistent actin filaments in a normal interphase nucleus. Furthe
PMID 27774069

Identification of Targets and Interaction Partners of Arginyl-tRNA Protein Transferase in the Moss Physcomitrella patens.

Hoernstein SN1, Mueller SJ1, Fiedler K1, Schuelke M1, Vanselow JT2, Schuessele C1, Lang D1, Nitschke R3, Igloi GL4, Schlosser A2, Reski R5.
Molecular & cellular proteomics : MCP.Mol Cell Proteomics.2016 Jun;15(6):1808-22. doi: 10.1074/mcp.M115.057190. Epub 2016 Apr 11.
Protein arginylation is a posttranslational modification of both N-terminal amino acids of proteins and sidechain carboxylates and can be crucial for viability and physiology in higher eukaryotes. The lack of arginylation causes severe developmental defects in moss, affects the low oxygen response i
PMID 27067052