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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2014/05/12 19:03:34」(JST)
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Haloxazolam
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| Systematic (IUPAC) name |
| 13-bromo-2-(2-fluorophenyl)-3-oxa-6,9-diazatricyclo[8.4.0.02,6]tetradeca-1(10),11,13-trien-8-one |
| Clinical data |
| AHFS/Drugs.com |
International Drug Names |
| Pregnancy cat. |
? |
| Legal status |
Schedule IV(US) |
| Routes |
Oral |
| Pharmacokinetic data |
| Bioavailability |
? |
| Metabolism |
Hepatic |
| Half-life |
? |
| Excretion |
Renal |
| Identifiers |
| CAS number |
59128-97-1 N |
| ATC code |
None |
| PubChem |
CID 3563 |
| DrugBank |
DB01476 |
| ChemSpider |
3442 Y |
| UNII |
verifiedrevid = 461766568 M448L2V8XP verifiedrevid = 461766568 N |
| KEGG |
D01758 N |
| ChEMBL |
CHEMBL2104461 N |
| Chemical data |
| Formula |
C17H14BrFN2O2 |
| Mol. mass |
377.208 g/mol |
SMILES
- Fc1ccccc1C42OCCN2CC(=O)Nc3c4cc(Br)cc3
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InChI
-
InChI=1S/C17H14BrFN2O2/c18-11-5-6-15-13(9-11)17(12-3-1-2-4-14(12)19)21(7-8-23-17)10-16(22)20-15/h1-6,9H,7-8,10H2,(H,20,22) Y
Key:XDKCGKQHVBOOHC-UHFFFAOYSA-N Y
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| N (what is this?) |
Haloxazolam (marketed in Japan under the brand name Somelin), is a drug which is a benzodiazepine derivative.[1][2][3] It has similar hypnotic properties as the benzodiazepine drugs triazolam, temazepam, and flunitrazepam and as such is indicated for the treatment insomnia.[4] A study in cats comparing estazolam and haloxazolam found that haloxazolam only affects gamma motor neurons, whereas estazolam affects both alpha and gamma motor neurons.[5]
See also
References
- ^ Tanaka, E; Terada, M; Misawa, S; Wakasugi, C (1996). "Simultaneous determination of twelve benzodiazepines in human serum using a new reversed-phase chromatographic column on a 2-microns porous microspherical silica gel". Journal of Chromatography B 682 (1): 173–8. doi:10.1016/0378-4347(96)00121-1. PMID 8832439.
- ^ "Benzodiazepine Names". non-benzodiazepines.org.uk. Retrieved 2009-04-05.
- ^ Guan, F; Seno, H; Ishii, A; Watanabe, K; Kumazawa, T; Hattori, H; Suzuki, O (1999). "Solid-phase microextraction and GC-ECD of benzophenones for detection of benzodiazepines in urine". Journal of analytical toxicology 23 (1): 54–61. PMID 10022210.
- ^ Tan, X; Uchida, S; Matsuura, M; Nishihara, K; Kojima, T (2003). "Long-, intermediate- and short-acting benzodiazepine effects on human sleep EEG spectra". Psychiatry and clinical neurosciences 57 (1): 97–104. doi:10.1046/j.1440-1819.2003.01085.x. PMID 12519461.
- ^ Sakai, Y (1983). "Comparative study on the effects of haloxazolam and estazolam, new sleep inducing drugs, on the alpha- and gamma-motor systems.". Japanese journal of pharmacology 33 (5): 1017–25. doi:10.1254/jjp.33.1017. PMID 6139494.
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Hypnotics/sedatives (N05C)
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GABAA
agonists/PAMs |
|
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GABAB
agonists |
- 1,4-Butanediol
- Aceburic acid
- GABOB
- GHB (Sodium oxybate)
- GBL
- GVL
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H1 inverse
agonists |
| Antihistamines: |
- Captodiame
- Cyproheptadine
- Diphenhydramine
- Doxylamine
- Hydroxyzine
- Methapyrilene
- Pheniramine
- Promethazine
- Propiomazine
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| Antidepressants |
- Tricyclic antidepressants
- Amitriptyline
- Doxepin
- Trimipramine, etc.
- Tetracyclic antidepressants
- Mianserin
- Mirtazapine, etc.
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|
| Antipsychotics |
- Typical antipsychotics
- Chlorpromazine
- Thioridazine, etc.
- Atypical antipsychotics
- Olanzapine
- Quetiapine
- Risperidone, etc.
|
|
|
α1-Adrenergic
antagonists |
| Antidepressants |
- Serotonin antagonists and reuptake inhibitors
- Tricyclic antidepressants
- Amitriptyline
- Doxepin
- Trimipramine, etc.
- Tetracyclic antidepressants
|
|
| Antipsychotics |
- Typical antipsychotics
- Chlorpromazine
- Thioridazine, etc.
- Atypical antipsychotics
- Olanzapine
- Quetiapine
- Risperidone, etc.
|
|
| Others: |
|
|
|
α2-Adrenergic
agonists |
- 4-NEMD
- Clonidine
- Detomidine
- Dexmedetomidine
- Lofexidine
- Medetomidine
- Romifidine
- Tizanidine
- Xylazine
|
|
5-HT2A
antagonists |
| Antidepressants |
- Serotonin antagonists and reuptake inhibitors
- Tricyclic antidepressants
- Amitriptyline
- Doxepin
- Trimipramine, etc.
- Tetracyclic antidepressants
- Mianserin
- Mirtazapine, etc.
|
|
| Antipsychotics |
- Typical antipsychotics
- Chlorpromazine
- Thioridazine, etc.
- Atypical antipsychotics
- Olanzapine
- Quetiapine
- Risperidone, etc.
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|
| Others: |
- Eplivanserin
- Niaprazine
- Pruvanserin
- Volinanserin
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|
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Melatonin
agonists |
- Agomelatine
- LY-156,735
- Melatonin
- Ramelteon
- Tasimelteon
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Orexin
antagonists |
- Almorexant
- SB-334,867
- SB-408,124
- SB-649,868
- Suvorexant
- TCS-OX2-29
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| Others |
- Acecarbromal
- Apronal
- Bromisoval
- Cannabidiol
- Carbromal
- Embutramide
- Evoxine
- Fenadiazole
- Gabapentin
- Kavalactones
- Mephenoxalone
- Opioids
- Passion flower
- Scopolamine
- UMB68
- Valnoctamide
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English Journal
- Solid-phase microextraction and GC-ECD of benzophenones for detection of benzodiazepines in urine.
- Guan F1, Seno H, Ishii A, Watanabe K, Kumazawa T, Hattori H, Suzuki O.
- Journal of analytical toxicology.J Anal Toxicol.1999 Jan-Feb;23(1):54-61.
- Benzodiazepines are common drugs that cause intoxication. Benzodiazepines and their metabolites can be converted by hydrolysis in acid to the corresponding benzophenones, which are easier to be separated from matrices because of their hydrophobic properties. In this study, a new separation technique
- PMID 10022210
- Simultaneous determination of twelve benzodiazepines in human serum using a new reversed-phase chromatographic column on a 2-microns porous microspherical silica gel.
- Tanaka E1, Terada M, Misawa S, Wakasugi C.
- Journal of chromatography. B, Biomedical applications.J Chromatogr B Biomed Appl.1996 Jun 28;682(1):173-8.
- A high-performance liquid chromatographic method has been developed for the simultaneous analysis of twelve frequently used benzodiazepines (BZPs) (bromazepam, clonazepam, chlordiazepoxide, estazolam, etizolam, flutazoram, haloxazolam, lorazepam, nitrazepam, oxazolam, triazolam and diazepam, interna
- PMID 8832439
Japanese Journal
- ＧＣ‐ＭＳによるベンゾジアゼピン系薬物および代謝物の一斉検査システム
- 西岡 裕,西川 眞弓,土橋 均
- 日本法科学技術学会誌 11(1), 53-75, 2006
- … A fully automated identification system for 35 benzodiazepines and their 29 metabolites was developed by gas chromatography-mass spectrometry (GC-MS) with a DB-5MS fused silica capillary column after trimethylsilyl (TMS) and trifluoroacetyl (TFA) derivatization, followed by registering both their retention times and mass spectra as the standard library data.All the analytes except for rilmazafone and haloxazolam were detectable with and/or without TMS derivatization. …
- NAID 130004942603
- Simultaneous determination of twelve benzodiazepines in human serum using a new reversed-phase chromatographic column on a 2-μm porous microspherical silica gel
- TANAKA Einosuke,TERADA Masaru,MISAWA Shogo,WAKASUGI Choei
- Journal of chromatography. B, Biomedical applications 682(1), 173-178, 1996-06-28
- NAID 10024556702
- 三環系抗うつ剤Ａｍｏｘａｐｉｎｅによる悪性症候群とおもわれる１例
- 長瀬 精一,羽田 忠,清水 文雄,前川 宗一郎,吉田 康洋,池尻 公二
- 医療 44(10), 1078-1082, 1990
- … 症例は42才の男性で, 抑うつ気分, 精神運動制止, 焦燥感, 不眠, 食欲減退などの症状で発病, うつ病の診断で, sulpride及びamoxapineの抗うつ剤, 抗不安剤(etizolam), 睡眠剤(nitrazepam, haloxazolam)を投与し, 約4週間後症状は改善した. …
- NAID 130004314364
Related Links
- Property Name Property Value Molecular Weight 377.2 g/mol XLogP3-AA 2.8 Hydrogen Bond Donor Count 1 Hydrogen Bond Acceptor Count 4 Rotatable Bond Count 1 Exact Mass 376.02227 g/mol Monoisotopic Mass 376.02227 g ...
- Haloxazolam ソメリン 300mg フェノバルビタール Phenobarbital フェノバール ワコビタール ヒダントール 複合アレビアチン トランコロンP 6g フルジアゼパム Fludiazepam エリスパン 22.5mg フルラゼパム Flurazepam ダルメート 900mg 15mg
- Haloxazolam ピナゼパム 600ミリグラム Pinazepam ビニルビタール 4.5グラム Vinylbital ピプラドロール 180ミリグラム Pipradrol ピロバレロン 2.4グラム Pyrobalerone フェノバルビタール 6グラム Phenobarbital フェンカンファミン 1.8グラム
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