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1. 避妊のための酢酸メドロキシプロゲステロンデポ剤 depot medroxyprogesterone acetate for contraception
2. 緩和ケア：疲労、脱力および無力症の概要 palliative care overview of fatigue weakness and asthenia
3. 資源の限られた状況における子宮頸癌のスクリーニング screening for cervical cancer in resource limited settings
4. 去勢抵抗性前立腺癌に対する二次内分泌療法 secondary endocrine therapies for castration resistant prostate cancer
5. βサラセミアの治療 treatment of beta thalassemia

Colorimetric detection of glutamine synthetase-catalyzed transferase activity in glucocorticoid-treated skeletal muscle cells.

Santoro JC, Harris G, Sitlani A.SourceDepartment of Molecular Endocrinology, Merck Research Laboratories, Rahway, New Jersey 07065, USA.
Analytical biochemistry.Anal Biochem.2001 Feb 1;289(1):18-25.
Induction of the enzyme glutamine synthetase (GS) by corticosteroids correlates with muscle wasting and gluconeogenesis, characteristic side effects of chronic glucocorticoid treatment. This highlights the importance of developing robust high-throughput assays to measure drug-induced GS in whole cel
PMID 11161290

Allergic rhinitis model with Brown Norway rat and evaluation of antiallergic drugs.

Takahashi N, Aramaki Y, Tsuchiya S.SourceTokyo College of Pharmacy, Japan.
Journal of pharmacobio-dynamics.J Pharmacobiodyn.1990 Jul;13(7):414-20.
An animal disease model of allergic rhinitis was developed with Brown Norway (BN) rat, a high immunoglobulin E responder strain. BN rats were immunized with ovalbumin (OA) and made to suffer from allergic rhinitis. The severity of allergic rhinitis was assessed by determining the extent of the three
PMID 1705288

A fifty-two-week chronic toxicity study of halopredone acetate (THS-201) in dogs.

Yamashita K, Yada H, Irimura K, Hayashi T, Morinaga H, Morita K.AbstractIn order to evaluate the long-term-safety of halopredone acetate (THS-201: 17 alpha, 21-diacetoxy-2-bromo-6 beta, 9 alpha-difluoro-11 beta-hydroxy-1, 4-pregnadiene-3, 20-dione), a 52-week chronic toxicity study was performed on the basis of its local accumulation in dogs. In doses of 0.1, 0.5 and 2.5 mg/kg, THS-201 was injected into the right knee joint in both sexes of dogs every 2 weeks for 39 weeks and withdrawn for 13 weeks. In this study, the below slight local changes were observed in both sexes of dogs treated with 2.5 mg/kg/2 weeks of THS-201: focal loss of hair of the injection site, lesser stain in cartilage matrix of articular cartilage and meniscus in light microscopic examinations, and irregular thickness and elongation of collagen fibers, roughness of fibrous density and decrement of proteoglycans in electron microscopic examinations. In conclusion, systemic adverse effects were not observed in any dogs treated with THS-201.
The Journal of toxicological sciences.J Toxicol Sci.1986 May;11 Suppl 2:81-106.
In order to evaluate the long-term-safety of halopredone acetate (THS-201: 17 alpha, 21-diacetoxy-2-bromo-6 beta, 9 alpha-difluoro-11 beta-hydroxy-1, 4-pregnadiene-3, 20-dione), a 52-week chronic toxicity study was performed on the basis of its local accumulation in dogs. In doses of 0.1, 0.5 and 2.
PMID 3761405