haloperidol

出典: meddic

ハロペリドール

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「tranquilizer (trade name Haldol) used to treat some psychotic disorders and Tourette''s syndrome」
Haldol

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出典(authority):フリー百科事典『ウィキペディア(Wikipedia)』「2016/11/09 05:48:54」(JST)

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出典(authority):フリー百科事典『ウィキペディア(Wikipedia)』「2018/12/20 18:52:32」(JST)

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英文文献

  • Role of cerebellar dopamine D3 receptors in modulating exploratory locomotion and cataleptogenicity in rats.
  • Shimizu S1, Tatara A1, Sato M1, Sugiuchi T1, Miyoshi S1, Andatsu S1, Kizu T1, Ohno Y2.Author information 1Laboratory of Pharmacology, Osaka University of Pharmaceutical Sciences, 4-20-1 Nasahara, Takatsuki, Osaka 569-1094, Japan.2Laboratory of Pharmacology, Osaka University of Pharmaceutical Sciences, 4-20-1 Nasahara, Takatsuki, Osaka 569-1094, Japan. Electronic address: yohno@gly.oups.ac.jp.AbstractDopamine D3 receptors are highly expressed in the cerebellum; however, their pathophysiological functions are not fully understood. Here, we conducted microinjection studies to clarify the role of cerebellar D3 receptors in modulating locomotion and cataleptogenicity in rats. Microinjection of the preferential D3 agonist 7-hydroxy-N,N-di-n-propyl-2-aminotetralin (7-OH-DPAT) into lobe 9 of the cerebellum significantly reduced spontaneous locomotor activity with a U-shaped dose-response curve. The intracerebellar microinjection of 7-OH-DPAT did not elicit catalepsy by itself, but markedly potentiated catalepsy induction with a low dose (0.3mg/kg) of haloperidol. The catalepsy enhancement by 7-OH-DPAT occurred in a dose-dependent manner and was not associated with the locomotor inhibition. U-99194A (a selective D3 antagonist) or AD-6048 (a preferential D3 vs. D2 antagonist) antagonized both the catalepsy enhancement and the locomotor inhibition with 7-OH-DPAT. In addition, U-99194A and AD-6048 per se significantly alleviated catalepsy induced by a high dose (0.5mg/kg) of haloperidol. Furthermore, microinjection of 7-OH-DPAT into the nucleus accumbens or the dorsolateral striatum neither affected spontaneous locomotor activity nor haloperidol (0.3mg/kg)-induced catalepsy. The present results illustrate for the first time the role of cerebellar D3 receptors in modulating cataleptogenicity of antipsychotic agents, implying that blockade of cerebellar D3 receptors contributes to the reduction of extrapyramidal side effects.
  • Progress in neuro-psychopharmacology & biological psychiatry.Prog Neuropsychopharmacol Biol Psychiatry.2014 Apr 3;50:157-62. doi: 10.1016/j.pnpbp.2013.12.013. Epub 2013 Dec 22.
  • Dopamine D3 receptors are highly expressed in the cerebellum; however, their pathophysiological functions are not fully understood. Here, we conducted microinjection studies to clarify the role of cerebellar D3 receptors in modulating locomotion and cataleptogenicity in rats. Microinjection of the p
  • PMID 24368396
  • Selective action of an atypical neuroleptic on the mechanisms related to the development of cocaine addiction: a pre-clinical behavioural study.
  • Marinho EA1, Oliveira-Lima AJ1, Wuo-Silva R2, Santos R3, Baldaia MA2, Hollais AW3, Longo BM3, Berro LF2, Frussa-Filho R2.Author information 1Departamento de Ciências da Saúde, UESC, Ilhéus, BA, Brazil.2Departamento de Farmacologia, UNIFESP, São Paulo, SP, Brazil.3Departamento de Fisiologia, UNIFESP, São Paulo, SP, Brazil.AbstractAn increased function in the mesolimbic dopaminergic system has been extensively associated with the rewarding effects of both natural stimuli and drugs of abuse. Thus, dopamine receptor blockers, such as neuroleptic drugs, can be proposed as candidates for potential therapeutic approaches to treat drug dependence. Notwithstanding, this therapeutic potential of neuroleptics critically depends on a selective action on the specific mechanisms related to the development of addiction. We compared the effects of different doses of haloperidol, ziprasidone and aripiprazole (first-, second- and third-generation neuroleptics, respectively) on spontaneous locomotor activity of mice in a novel environment, hyperlocomotion induced by acute cocaine administration and cocaine-induced locomotor sensitization by a two-injection protocol. Whereas high doses of haloperidol abolished the three behavioural paradigms without selectivity, low doses of ziprasidone selectively abolished the development of the behavioural sensitization phenomenon. Finally, low doses of aripiprazole inhibited acute cocaine-induced hyperlocomotion and behavioural sensitization without modifying spontaneous locomotor activity. Thus, aripiprazole at lower doses was the most selective antipsychotic drug concerning the inhibition of the development of behavioural sensitization to cocaine. Because locomotor sensitization in rodents has been proposed to share plastic mechanisms with drug addiction in humans, our data provide relevant suggestions to the clinical practice.
  • The international journal of neuropsychopharmacology / official scientific journal of the Collegium Internationale Neuropsychopharmacologicum (CINP).Int J Neuropsychopharmacol.2014 Apr;17(4):613-23. doi: 10.1017/S1461145713001430. Epub 2013 Dec 17.
  • An increased function in the mesolimbic dopaminergic system has been extensively associated with the rewarding effects of both natural stimuli and drugs of abuse. Thus, dopamine receptor blockers, such as neuroleptic drugs, can be proposed as candidates for potential therapeutic approaches to treat
  • PMID 24345415
  • Dopamine is differentially involved in the locomotor hyperactivity produced by manipulations of opioid, GABA and glutamate receptors in the median raphe nucleus.
  • Shim I1, Stratford TR2, Wirtshafter D3.Author information 1Department of Psychology, University of Illinois at Chicago M/C 285 1007 W. Harrison St., Chicago 60607-7137, IL, U.S.A; AMSRC, Department of Basic Science College of Oriental Medicine, Kyung Hee University, Seoul 130-701, Korea.2Department of Psychology, University of Illinois at Chicago M/C 285 1007 W. Harrison St., Chicago 60607-7137, IL, U.S.A.3Department of Psychology, University of Illinois at Chicago M/C 285 1007 W. Harrison St., Chicago 60607-7137, IL, U.S.A. Electronic address: davew@uic.edu.AbstractThe median raphe nucleus (MR) has been shown to exert a powerful influence on behavioral arousal and marked locomotor hyperactivity can be produced by intra-MR injections of a variety of drugs including GABAA and GABAB agonists, excitatory amino acid antagonists, and μ- and δ-opioid agonists. Other studies have indicated that the MR exerts an inhibitory influence on ascending dopamine systems, suggesting that MR induced alterations in activity may be mediated through changes in dopaminergic transmission. In the present study, we explored this possibility by examining whether systemic administration of the preferential D2 dopamine antagonist haloperidol is able to antagonize the hyperactivity produced by intra-MR injections of various drugs. We found that haloperidol completely blocked the locomotor response to intra-MR injections of the μ-opioid receptor agonist DAMGO and the δ-opioid receptor agonist DPDPE. In marked contrast, at doses which abolished the locomotor response to systemic amphetamine, haloperidol had no effect on the hyperactivity induced by intra-MR injections of GABAA agonist muscimol, the GABAB agonist baclofen, or the kainate/quisqualate antagonist pBB-PZDA, even though it suppressed baseline activity in these same animals. These results indicate that there must be at least two mechanisms capable of influencing behavioral arousal within the MR region, one of which is dependent on D2 dopamine receptors and the other is not.
  • Behavioural brain research.Behav Brain Res.2014 Mar 15;261:65-70. doi: 10.1016/j.bbr.2013.12.004. Epub 2013 Dec 12.
  • The median raphe nucleus (MR) has been shown to exert a powerful influence on behavioral arousal and marked locomotor hyperactivity can be produced by intra-MR injections of a variety of drugs including GABAA and GABAB agonists, excitatory amino acid antagonists, and μ- and δ-opioid agonists. Othe
  • PMID 24333380

和文文献

  • 強迫性障害の動物モデルであるマーブル・ベーリング行動に関する研究
  • 松下 満彦,江頭 伸昭,奥野 良子,原田 聡子,塚田 淳也,清原 義明,千鳥 正三,内田 直樹,三島 健一,岩崎 克典,藤原 道弘,西村 良二
  • 福岡大学医学紀要 39(2), 163-171, 2012-06
  • NAID 110009422856
  • α-ラクトアルブミン,ラクトフェリンおよびリゾチームのハロペリドール様作用
  • 折笠 修三,岩附 慧二
  • ミルクサイエンス 61(1), 1-9, 2012-04
  • NAID 40019236463
  • 症例報告 初老期に片側舞踏運動で発症したもやもや病の1例
  • 金星 匡人,井上 学,小島 康祐 [他]
  • 臨床神経学 52(1), 25-29, 2012-01
  • NAID 40019173948

関連リンク

ハロペリドールとは。効果、副作用、使用上の注意。抗精神病剤は、中枢神経や自律神経のはたらきを強力に抑制する作用をもち、興奮、幻想、妄想、不安、緊張といった精神症状を鎮静させる効果があります。また、精神活動の低下 ...
Before taking haloperidol, tell your doctor and pharmacist if you are allergic to haloperidol or any other medications. tell your doctor and pharmacist what prescription and nonprescription medications, vitamins, nutritional ...

関連画像

Haloperidol Prodes PrintHaloperidol Lactate Antipsychotic Agent 5 HALOPERIDOL (HALOPERIDOL)Haloperidol - What is Haloperidol?Description Haloperidol 10 MG Oral Tablet File: Haloperidol Structural


★リンクテーブル★
リンク元薬理学」「ハロペリドール

薬理学」

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pharmacology
drug entries


定義

  • 生物系と化学物質の選択的な相互作用を研究する学問 (SPC.2)

生物系と薬の相互作用

  • 薬の生物系に対する相互作用:薬理作用 <-化学の視点
  • 生物系の薬に対する相互作用:薬物動態 <-生物の視点

関連分野

  • 薬物学 materia medica
  • 生薬学
  • 実験薬理学
  • 臨床薬理学
  • 動物薬理学
  • 人体薬理学
  • 比較薬理学
  • 薬理作用学(薬力学)
  • 薬物動態学
  • 中毒学、毒科学
  • 薬物治療学
  • 処方学

薬品の命名

Ending of the drug name Category Example
~afil Erectile dysfunction sildenafil
~ane Inhalatinal general anesthetic halothane
~azepam Benzodiaizepine diazepam
~azine Phenothiazine (neuroleptic, antiemetic) chlorpromazine
~azole Ailtifungal ketoconazole
~barbital Barbiturate phenobarbital
~caine Local anesthetic lidocaine
~cillin Penicillin methicillin
~cycline Antibiotic, protein syntlesis inhibitor tetracycline
~ipramine TCA iimipramine
~navir Protease inhibitor saquinavir
~olol β-antagonist propranolol
~operidol Butyrophenone ( neuroleptic ) haloperidol
~oxin Cardiac glycoside ( inotropic agent ) digoxin
~phylline Methylxanthine theophylline
~pril ACE inhibitor captopril
~terol β2 agonist albuterol
~tidine H2 antagonist cimtidine
~triptyline TCA amitriptyline
~tropine Pituitary hormone somatotropine
~zosin a1 antagonist prazosin

薬一覧

薬物代謝

薬理動態

神経伝達物質

神経筋接合部遮断薬(筋弛緩薬)

交感神経作動薬

アドレナリン受容体

交感神経遮断薬

アドレナリン受容体

副交感神経作動薬

アセチルコリン受容体

副交感神経遮断薬

アセチルコリン受容体

貧血治療薬

甲状腺関連物質

痛風治療薬

  • 痛風発作予防薬
  • 尿酸排泄促進薬
  • 尿酸生成抑制薬


ハロペリドール」

  [★]

haloperidol
haloperidolum
ケセランネオペリドールハロマンスエセックチンコスミナールスイロリンハロジャストハロステンハロミドールヨウペリドールレモナミンリントンセレネースHaldol
抗精神病薬

特徴

  • 作用が強力なので統合失調症の急性期によい。
  • 催眠作用、自律神経症状、血圧低下などの循環器での急性治療に用いられる。

構造

C21H23ClFNO2。

作用機序

薬理作用

動態

適応

  • 統合失調症
  • そう病

注意

禁忌

  • 昏睡、重要心不全、パーキンソン病、妊婦

副作用

フェノチアジン系のクロルプロマジンより抗ムスカリン作用が弱い

相互作用



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