halofantrine

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出典(authority):フリー百科事典『ウィキペディア(Wikipedia)』「2016/05/03 12:37:17」(JST)

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英文文献

  • A mouse model to evaluate the impact of species, sex, and lipid load on lymphatic drug transport.
  • Trevaskis NL, Caliph SM, Nguyen G, Tso P, Charman WN, Porter CJ.Author information Drug Delivery, Disposition and Dynamics Monash Institute of Pharmaceutical Sciences, Monash University (Parkville Campus), 381 Royal Parade, Parkville, Victoria, Australia, 3052, Natalie.Trevaskis@monash.edu.AbstractPURPOSE: To establish a lymph-cannulated mouse model, and use the model to investigate the impact of lipid dose on exogenous and endogenous lipid recruitment, and drug transport, into the lymph of males versus females. Finally, lymphatic transport and drug absorption in the mouse were compared to other pre-clinical models (rats/dogs).
  • Pharmaceutical research.Pharm Res.2013 Dec;30(12):3254-70. doi: 10.1007/s11095-013-1000-0. Epub 2013 Feb 21.
  • PURPOSE: To establish a lymph-cannulated mouse model, and use the model to investigate the impact of lipid dose on exogenous and endogenous lipid recruitment, and drug transport, into the lymph of males versus females. Finally, lymphatic transport and drug absorption in the mouse were compared to ot
  • PMID 23430484
  • [Treatment of severe and uncomplicated falciparum malaria in children in France].
  • Pull L, Bellettre X, Michel JF, Bouchaud O, Siriez JY.Author information Service d'accueil des urgences pédiatriques, hôpital Robert-Debré, AP-HP, 48, boulevard Sérurier, 75019 Paris, France. Electronic address: lauren.pull@rdb.aphp.fr.AbstractQuinine was the main treatment for malaria between 1630 and the beginning of the XXth century. In the 1940s, the synthesis of chloroquine gave rise to the hope of eliminating this plague. Falciparum resistance to chloroquine, first observed in Asia then in sub-Saharan Africa, lead researchers to discover halofantrine, mefloquine, atovaquone-proguanil and artemisinin combined therapies. There is no ideal treatment for uncomplicated imported malaria in children. Medical teams have to develop a protocol according to available drugs and their personal experience, with a special attention to follow-up at days 3-4 and day 28. From now on, severe malaria must be treated with intravenous artesunate, a more effective therapy than quinine.
  • Archives de pédiatrie : organe officiel de la Sociéte française de pédiatrie.Arch Pediatr.2013 Nov;20(11):1260-4. doi: 10.1016/j.arcped.2013.08.002. Epub 2013 Oct 2.
  • Quinine was the main treatment for malaria between 1630 and the beginning of the XXth century. In the 1940s, the synthesis of chloroquine gave rise to the hope of eliminating this plague. Falciparum resistance to chloroquine, first observed in Asia then in sub-Saharan Africa, lead researchers to dis
  • PMID 24094758
  • Characterization of Polymer Adsorption onto Drug Nanoparticles Using Depletion Measurements and Small-Angle Neutron Scattering.
  • Goodwin DJ, Sepassi S, King SM, Holland SJ, Martini LG, Lawrence MJ.Author information Institute of Pharmaceutical Science, King's College London , Stamford Street, London SE1 9NH, United Kingdom.AbstractProduction of polymer and/or surfactant-coated crystalline nanoparticles of water-insoluble drugs (nanosuspensions) using wet bead milling is an important formulation approach to improve the bioavailability of said compounds. Despite the fact that there are a number of nanosuspensions on the market, there is still a deficiency in the characterization of these nanoparticles where further understanding may lead to the rational selection of polymer/surfactant. To this end small-angle neutron scattering (SANS) measurements were performed on drug nanoparticles milled in the presence of a range of polymers of varying molecular weight. Isotopic substitution of the aqueous solvent to match the scattering length density of the drug nanoparticles (i.e., the technique of contrast matching) meant that neutron scattering resulted only from the adsorbed polymer layer. The layer thickness and amount of hydroxypropylcellulose adsorbed on nabumetone nanoparticles derived from fitting the SANS data to both model-independent and model dependent volume fraction profiles were insensitive to polymer molecular weight over the range Mv = 47-112 kg/mol, indicating that the adsorbed layer is relatively flat but with tails extending up to approximately 23 nm. The constancy of the absorbed amount is in agreement with the adsorption isotherm determined by measuring polymer depletion from solution in the presence of the nanoparticles. Insensitivity to polymer molecular weight was similarly determined using SANS measurements of nabumetone or halofantrine nanoparticles stabilized with hydroxypropylmethylcellulose or poly(vinylpyrrolidone). Additionally SANS studies revealed the amount adsorbed, and the thickness of the polymer layer was dependent on both the nature of the polymer and drug particle surface. The insensitivity of the adsorbed polymer layer to polymer molecular weight has important implications for the production of nanoparticles, suggesting that lower molecular weight polymers should be used when preparing nanoparticles by wet bead milling since nanoparticle formation is more rapid but with no likely consequence on the resultant physical stability of the nanoparticles.
  • Molecular pharmaceutics.Mol Pharm.2013 Oct 22. [Epub ahead of print]
  • Production of polymer and/or surfactant-coated crystalline nanoparticles of water-insoluble drugs (nanosuspensions) using wet bead milling is an important formulation approach to improve the bioavailability of said compounds. Despite the fact that there are a number of nanosuspensions on the market,
  • PMID 24074034

和文文献

  • PRESCRIPTION PATTERNS OF ANTIMALARIAL DRUGS AMONG MEDICAL PRACTITIONERS IN OSOGBO METROPOLIS. SOUTH-WEST NIGERIA.
  • Interaction of the Antimalarial Agents Halofantrine and Lumefantrine with Lipid Bilayers
  • Halofantrine-Phospholipid Interactions : Monolayer Studies

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PharmGKB contains no dosing guidelines for this drug/small molecule. To report known genotype-based dosing guidelines, or if you are interested in developing ... Disclaimer: The PharmGKB's clinical annotations reflect expert ...

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halofantrineHalofantrineHalofantrine - 3D - Stick Model.pngHalofantrine synthesis [ 7 ]Description Heme Halofantrine complex.pngHalofantrine.



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