haemoglobinuria

Hemoglobinuria
	Structure of hemoglobin
Classification and external resources
ICD-10	R82.3
ICD-9-CM	283.2, 791.2
DiseasesDB	19635
MeSH	D006456
	[edit on Wikidata]

ヘモグロビン尿症、血色素尿症、ヘモグロビン尿、血色素尿

Wikipedia preview

出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2016/05/06 16:14:18」(JST)

wiki en

[Wiki en表示]

In medicine, hemoglobinuria or haemoglobinuria is a condition in which the oxygen transport protein hemoglobin is found in abnormally high concentrations in the urine. The condition is often associated with hemolytic anemia, in which red blood cells (RBCs) are destroyed, thereby increasing levels of free plasma hemoglobin. Excess hemoglobin is filtered by the kidneys, which excrete it into the urine, giving urine a purple color.

Causes

Acute glomerulonephritis
Burns
Renal cancer
Malaria
Paroxysmal nocturnal hemoglobinuria
Microangiopathies, e.g. Hemolytic-uremic syndrome (HUS), Thrombotic thrombocytopenic purpura (TTP)
Transfusion reactions
IgM autoimmune hemolytic anemia
Pyelonephritis
Sickle cell anemia
Tuberculosis of the urinary tract
March hemoglobinuria secondary to repetitive impacts on the body, usually the feet
Athletic nephritis secondary to strenuous exercise
Acute lead poisoning

Complications

Hemoglobinuria can lead to acute tubular necrosis which is an uncommon cause of a death of uni-traumatic patients recovering in the ICU .

Diagnosis

The diagnosis is often made based on the medical history, blood samples, and a urine sample. The absence of urine RBCs and RBC casts microscopically despite a positive dipstick test suggests hemoglobinuria or myoglobinuria. The medical term for RBCs in the urine is hematuria.

UpToDate Contents

全文を閲覧するには購読必要です。 To read the full text you will need to subscribe.

1. 発作性夜間血色素尿症の臨床症状および診断 clinical manifestations and diagnosis of paroxysmal nocturnal hemoglobinuria
2. 腎疾患の診断における尿検査 urinalysis in the diagnosis of kidney disease
3. 発作性寒冷血色素尿症 paroxysmal cold hemoglobinuria
4. 小児における溶血性貧血の概要 overview of hemolytic anemias in children
5. 発作性夜間血色素尿症の治療および予後 treatment and prognosis of paroxysmal nocturnal hemoglobinuria

English Journal

Paroxysmal nocturnal hemoglobinuria (PNH) and T cell large granular lymphocyte (LGL) leukemia-an unusual association: another cause of cytopenia in PNH.

Boyer T1, Grardel N, Copin MC, Roumier C, Touzart A, Buchdahl AL, Corm S, Peffault de Latour R, Preudhomme C, Terriou L.
Annals of hematology.Ann Hematol.2015 Oct;94(10):1759-60. doi: 10.1007/s00277-015-2439-3. Epub 2015 Jul 9.
PMID 26152552

Therapeutic drug monitoring of eculizumab: rationale for an individualized dosing schedule.

Gatault P1, Brachet G, Ternant D, Degenne D, Récipon G, Barbet C, Gyan E, Gouilleux-Gruart V, Bordes C, Farrell A, Halimi JM, Watier H.
mAbs.MAbs.2015 Sep 4:0. [Epub ahead of print]
The annual cost of eculizumab maintenance therapy in paroxysmal nocturnal hemoglobinuria (PNH) and atypical hemolytic-uremic syndrome (aHUS) exceeds $300,000 per patient. A better understanding of eculizumab pharmacokinetics and subsequent individual dose adjustment could reduce this cost. We measur
PMID 26337866

Balloon-Occluded Retrograde Transvenous Obliteration for the Treatment of Gastric Varices: Polidocanol Foam Versus Liquid Ethanolamine Oleate.

Itou C1, Koizumi J1, Hashimoto T2, Myojin K3, Kagawa T4, Mine T4, Imai Y1.
AJR. American journal of roentgenology.AJR Am J Roentgenol.2015 Sep;205(3):659-66. doi: 10.2214/AJR.14.13389.
OBJECTIVE: The purpose of this study was to evaluate the clinical results of the management of gastric varices by balloon-occluded retrograde transvenous obliteration with polidocanol foam versus ethanolamine oleate.MATERIALS AND METHODS: Twenty patients treated with ethanolamine oleate and 21 patie
PMID 26295655