hachimycin

ハチマイシン

関

trichomycin

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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2014/01/16 22:45:05」(JST)

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Hachimycin

Systematic (IUPAC) name
A: (19E,21E,23E,25E,27E,29E,31E)-33-{[(2R,3S,4S,5S,6R)-4-amino-3,5-dihydroxy-6-methyloxan-2-yl]oxy}-17-[7-(4-aminophenyl)-5-hydroxy-7-oxoheptan-2-yl]-1,3,5,9,11,37-hexahydroxy-18-methyl-13,15-dioxo-16,39-dioxabicyclo[33.3.1]nonatriaconta-19,21,23,25,27,29,31-heptaene-36-carboxylic acid B: (19E,21E,23E,25E,27E,29E,31E)-33-{[(2R,3S,4S,5S,6R)-4-amino-3,5-dihydroxy-6-methyloxan-2-yl]oxy}-17-[7-(4-aminophenyl)-5-hydroxy-7-oxoheptan-2-yl]-1,5,7,9,11,37-hexahydroxy-18-methyl-13,15-dioxo-16,39-dioxabicyclo[33.3.1]nonatriaconta-19,21,23,25,27,29,31-heptaene-36-carboxylic acid
Clinical data
Legal status	?
Identifiers
ATC code	D01AA03 G01AA06 J02AA02
PubChem	CID 11979956
ChemSpider	10153168 Y
Chemical data
Formula	C58H84N2O18
Mol. mass	1097.2902 g/mol
InChI InChI=1S/2C58H84N2O18/c1-35-17-14-12-10-8-6-4-5-7-9-11-13-15-20-46(76-57-54(71)52(60)53(70)37(3)75-57)32-49-51(56(72)73)48(68)34-58(74,78-49)33-45(66)29-44(65)28-43(64)27-40(61)18-16-19-41(62)31-50(69)77-55(35)36(2)21-26-42(63)30-47(67)38-22-24-39(59)25-23-38;1-35-17-14-12-10-8-6-4-5-7-9-11-13-15-20-46(76-57-54(71)52(60)53(70)37(3)75-57)32-49-51(56(72)73)48(68)34-58(74,78-49)33-45(66)28-41(62)19-16-18-40(61)27-43(64)29-44(65)31-50(69)77-55(35)36(2)21-26-42(63)30-47(67)38-22-24-39(59)25-23-38/h4-15,17,20,22-25,35-37,40,42-46,48-49,51-55,57,61,63-66,68,70-71,74H,16,18-19,21,26-34,59-60H2,1-3H3,(H,72,73);4-15,17,20,22-25,35-37,40-43,45-46,48-49,51-55,57,61-64,66,68,70-71,74H,16,18-19,21,26-34,59-60H2,1-3H3,(H,72,73)/b5-4-,8-6-,9-7-,12-10-,13-11-,17-14-,20-15-;5-4+,8-6+,9-7+,12-10+,13-11+,17-14-,20-15+/t35?,36?,37-,40?,42?,43?,44?,45?,46?,48?,49?,51?,52+,53-,54+,55?,57+,58?;35?,36?,37-,40?,41?,42?,43?,45?,46?,48?,49?,51?,52+,53-,54+,55?,57+,58?/m11/s1 Y Key:RZWQQZWPVPHLSY-UGMBPVHXSA-N Y
Y (what is this?)  (verify)

Hachimycin is a polyene antibiotic.

References

UpToDate Contents

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• 1. 脳血管性認知症の病因、臨床症状、および診断etiology clinical manifestations and diagnosis of vascular dementia [show details]
  …diagnosis of vascular dementia, AD, or multiple-etiology dementia due to vascular dementia and AD. The Hachinski ischemic score is a simple clinical tool that uses elements of the history and routine physical …

English Journal

• Inhibitory effect of trichostatin on allograft rejection of corneal transplantation in rats.

• Maimaitiming R1, Yang X1, Wupuer K1, Ye N1, Pan Z2.
• International journal of clinical and experimental medicine.Int J Clin Exp Med.2015 Aug 15;8(8):12424-9. eCollection 2015.
• BACKGROUND: Using a rat penetrating keratoplasty model, this study aims to explore the inhibitory effect of hachimycin on corneal graft rejection, to provide new basis for its clinical application.MATERIALS AND METHODS: Female adult Sprague-Dawley (SD) rats weighing between 220-250 g were used as ac
• PMID 26550154

• [The cis-trans isomerization of aromatic heptaenes catalyzed by sulfur and phosphorus compounds].

• Shenin IuD1, Filippova AI.
• Antibiotiki i khimioterapii︠a︡ = Antibiotics and chemoterapy [sic] / Ministerstvo meditsinskoĭ i mikrobiologicheskoĭ promyshlennosti SSSR.Antibiot Khimioter.2000;45(6):7-9.
• It was shown that sulfur and phosphorus compounds (sodium thiosulfate, sodium tripolyphosphate, sodium hexametaphosphate, monosodium phosphate) catalyze cis-trans isomerization of aromatic heptaens. Preparative method of levorin isomerezation at the presence of sodium thiosulfate was elaborated. The
• PMID 10904801

• [Dye-sensitized photoisomerization of polyenic macrolide antibiotics].

• Shenin IuD, Filippova AI.
• Antibiotiki i khimioterapii︠a︡ = Antibiotics and chemoterapy [sic] / Ministerstvo meditsinskoĭ i mikrobiologicheskoĭ promyshlennosti SSSR.Antibiot Khimioter.1994 Sep-Oct;39(9-10):12-8.
• Photoisomerization of levorin A2, a polyenic macrolide, sensitized by various dyes such as thiazines, acridines, xanthenes and phthalocyanines was studied. The use of the dyes made it possible to shift the isomerization process to the visible spectrum region and to increase the quantum yield to 1. T
• PMID 7695443

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リンク元

「ハチマイシン」

「ハチマイシン」

　　[★]

英

hachimycin

関

トリコマイシン