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1. 胎児サーベイランスのための臍動脈ドップラー超音波検査doppler ultrasound of the umbilical artery for fetal surveillance [show details]
…bradykinin, endothelin 1, and prostaglandin F2alpha induce contraction, while activation of adenylyl and guanylyl (or guanylate) cyclases, potassium channels, and the inhibition of calcium channels cause vasorelaxation…
2. 成人への一酸化窒素吸入療法：生物学と適用対象inhaled nitric oxide in adults biology and indications for use [show details]
…an ideal agent for pulmonary vasoreactivity testing. Mechanism of action – NO activates soluble guanylyl cyclase (sGC) to produce cyclic guanosine monophosphate (cGMP), which then activates cGMP dependent…
3. 慢性疼痛にオピオイド鎮痛薬を処方されている場合の副作用の予防とマネージメントprevention and management of side effects in patients receiving opioids for chronic pain [show details]
…safety of these therapies, a trial in patients with OIC would not be unreasonable . Linaclotide, a guanylyl cyclase C agonist, is approved for the treatment of irritable bowel syndrome and chronic idiopathic …
4. 切迫早産の予防inhibition of acute preterm labor [show details]
…reaction is catalyzed by the enzyme nitric oxide synthase (NOS). The interaction between NO and soluble guanylyl cyclase (sGC), which is present in nearby effector cells, represents a widespread signal transduction…
5. 術中にショック状態に陥った成人患者のマネージメントintraoperative management of shock in adults [show details]
…vasodilatory shock. Methylene blue administered as a dose of 1 to 2 mg/kg over 20 minutes inhibits guanylyl cyclase and NO synthase activity, which reduces resistance vessel responsiveness to nitric oxide…

English Journal

The protonation states of GTP and GppNHp in Ras proteins.

Mann D, Güldenhaupt J, Schartner J, Gerwert K, Kötting C.
The Journal of biological chemistry. 2018 03;293(11)3871-3879.
The small GTPase Ras transmits signals in a variety of cellular signaling pathways, most prominently in cell proliferation. GTP hydrolysis in the active center of Ras acts as a prototype for many GTPases and is the key to the understanding of several diseases, including cancer. Therefore, Ras has be
PMID 29382720

Structural insights into ribosomal rescue by Dom34 and Hbs1 at near-atomic resolution.

Hilal T, Yamamoto H, Loerke J, Bürger J, Mielke T, Spahn CM.
Nature communications. 2016 12;7()13521.
The surveillance of mRNA translation is imperative for homeostasis. Monitoring the integrity of the message is essential, as the translation of aberrant mRNAs leads to stalling of the translational machinery. During ribosomal rescue, arrested ribosomes are specifically recognized by the conserved eu
PMID 27995908

Sar1 GTPase Activity Is Regulated by Membrane Curvature.

Hanna MG, Mela I, Wang L, Henderson RM, Chapman ER, Edwardson JM, Audhya A.
The Journal of biological chemistry. 2016 Jan;291(3)1014-27.
The majority of biosynthetic secretory proteins initiate their journey through the endomembrane system from specific subdomains of the endoplasmic reticulum. At these locations, coated transport carriers are generated, with the Sar1 GTPase playing a critical role in membrane bending, recruitment of
PMID 26546679

Japanese Journal

Changes in ^3H-Quinuclidinyl Benzilate Binding and Protein Synthesis in the Striatum Following Chronic Administrations of Muscarinic Agonist

HONDA Kenji,TAKANO Yukio,KAMIYA Hiro-o
The Japanese journal of pharmacology 67(1), 83-86, 1995-01-01
… Furthermore, it eliminated the shift from the high affinity site to the low affinity site that occurs in the presence of 5-guanylyl imidodiphosphate (Gpp (NH)p). …
NAID 10005710012

Binding of a Catechol Derivative of Denopamine (T-0509) and N-tert-Butylnoradrenaline (Colterol) to β_1-and β_2-Adrenoceptors

草山俊之,岡淳一郎,矢花秀雄,赤羽悟美,長尾拓
Biological & Pharmaceutical Bulletin 17(8), 1023-1028, 1994-08-15
… Addition of 5'-guanylyl-imidodiphosphate (GppNHp, 30μM) led to a rightward shift of the ^3H-DHA binding displacement curves of T-0509 and Col in both membranes, and the degree of shift was similar to that of full agonists such as isoproterenol (Iso), adrenaline (Adr) and noradrenaline (NA). …
NAID 110003640699