guanylthiourea

English Journal

Design and synthesis of guanylthiourea derivatives as potential inhibitors of Plasmodium falciparum dihydrofolate reductase enzyme.

Adane L1, Bhagat S1, Arfeen M1, Bhatia S1, Sirawaraporn R2, Sirawaraporn W2, Chakraborti AK1, Bharatam PV3.
Bioorganic & medicinal chemistry letters.Bioorg Med Chem Lett.2014 Jan 15;24(2):613-7. doi: 10.1016/j.bmcl.2013.12.009. Epub 2013 Dec 8.
A new class of compounds based on S-benzylated guanylthiourea has been designed as potential PfDHFR inhibitors using computer aided methods (molecular electrostatic potential, molecular docking). Several compounds in this class have been synthesized starting from guanylthiourea and alkyl bromides. I
PMID 24361001

Antihypoxic and antioxidant effects of exogenous succinic acid and aminothiol succinate-containing antihypoxants.

Zarubina IV1, Lukk MV, Shabanov PD.
Bulletin of experimental biology and medicine.Bull Exp Biol Med.2012 Jul;153(3):336-9.
Pronounced antihypoxic and antioxidant effects of preventive injection of succinic acid, aminothiol antihypoxants gutimine and amtizol, and succinate-containing aminothiol antihypoxants gutimine succinate and amtizol succinate to Wistar rats with acute hypoxic hypoxia have been demonstrated. Exogeno
PMID 22866305

Electronic structure and reactivity of guanylthiourea: a quantum chemical study.

Mehdi A1, Adane L, Patel DS, Bharatam PV.
Journal of computational chemistry.J Comput Chem.2010 Apr 30;31(6):1259-67. doi: 10.1002/jcc.21412.
Electronic structure analysis of guanylthiourea (GTU) and its isomers has been carried out using quantum chemical methods. Two major tautomeric classes (thione and thiol) have been identified on the potential energy (PE) surface. In both the cases conjugation of pi-electrons and intramolecular H-bon
PMID 19890877