グアニンデアミナーゼ
WordNet
- a purine base found in DNA and RNA; pairs with cytosine (同)G
Wikipedia preview
出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2014/01/02 12:50:16」(JST)
[Wiki en表示]
| guanine deaminase |
| Identifiers |
| Symbol |
GDA |
| Entrez |
9615 |
| HUGO |
4212 |
| OMIM |
139260 |
| RefSeq |
NM_004293 |
| UniProt |
Q9Y2T3 |
| Other data |
| Locus |
Chr. 9 q21.11-21.33 |
Guanine deaminase (EC 3.5.4.3, guanase, guanine aminase, GAH, guanine aminohydrolase) is an enzyme which converts guanine to xanthine.[1][2][3]
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xanthine. Note nitrogen replaced with oxygen. (Ignore rotation.)
References[edit]
- ^ Hitchings, G.H. and Falco, E.A. (1944). "The identification of guanine in extracts of Girella nigricans. The specificity of guanase". Proc. Natl. Acad. Sci. USA 30: 294–297. doi:10.1073/pnas.30.10.294. PMC 1078714. PMID 16578130.
- ^ Kalckar, H.M. (1947). "Differential spectrophotometry of purine compounds by means of specific enzymes. III. Studies of the enzymes of purine metabolism". J. Biol. Chem. 167: 461–475.
- ^ Rabinowitz, J.C. and Barker, H.A. (1956). "Purine fermentation by Clostridium cylindrosporum. II. Purine transformations". J. Biol. Chem. 218 (1): 161–173. PMID 13278325.
External links[edit]
- Guanine deaminase at the US National Library of Medicine Medical Subject Headings (MeSH)
|
Hydrolases: carbon-nitrogen non-peptide (EC 3.5)
|
|
3.5.1: Linear amides /
Amidohydrolases |
- Asparaginase
- Glutaminase
- Urease
- Biotinidase
- Aspartoacylase
- Ceramidase
- Aspartylglucosaminidase
- Fatty acid amide hydrolase
- Histone deacetylase
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|
3.5.2: Cyclic amides/
Amidohydrolases |
- Barbiturase
- Beta-lactamase
|
|
3.5.3: Linear amidines/
Ureohydrolases |
- Arginase
- Agmatinase
- Protein-arginine deiminase
|
|
3.5.4: Cyclic amidines/
Aminohydrolases |
- Guanine deaminase
- Adenosine deaminase
- AMP deaminase
- Inosine monophosphate synthase
- DCMP deaminase
- GTP cyclohydrolase I
- Cytidine deaminase
- AICDA
- Activation-Induced (Cytidine) Deaminase
|
|
3.5.5: Nitriles/
Aminohydrolases |
|
|
| 3.5.99: Other |
- Riboflavinase
- Thiaminase II
|
|
- B
- enzm
- 1.1
- 2
- 3
- 4
- 5
- 6
- 7
- 8
- 10
- 11
- 13
- 14
- 15-18
- 2.1
- 3.1
- 4.1
- 5.1
- 6.1-3
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|
|
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Metabolism: amino acid metabolism · nucleotide enzymes
|
|
| Purine metabolism |
|
Anabolism
|
R5P->IMP: Ribose-phosphate diphosphokinase · Amidophosphoribosyltransferase · Phosphoribosylglycinamide formyltransferase · AIR synthetase (FGAM cyclase) · Phosphoribosylaminoimidazole carboxylase · Phosphoribosylaminoimidazolesuccinocarboxamide synthase · IMP synthase
IMP->AMP: Adenylosuccinate synthase · Adenylosuccinate lyase · reverse (AMP deaminase)
IMP->GMP: IMP dehydrogenase · GMP synthase · reverse (GMP reductase)
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|
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Nucleotide salvage
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Hypoxanthine-guanine phosphoribosyltransferase · Adenine phosphoribosyltransferase
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|
|
Catabolism
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Adenosine deaminase · Purine nucleoside phosphorylase · Guanine deaminase · Xanthine oxidase · Urate oxidase
|
|
|
| Pyrimidine metabolism |
|
Anabolism
|
CAD (Carbamoyl phosphate synthase II, Aspartate carbamoyltransferase, Dihydroorotase)
Dihydroorotate dehydrogenase · Orotidine 5'-phosphate decarboxylase/Uridine monophosphate synthetase
CTP synthase
|
|
|
Catabolism
|
Dihydropyrimidine dehydrogenase · Dihydropyrimidinase/DPYS · Beta-ureidopropionase/UPB1
|
|
|
| Deoxyribonucleotides |
Ribonucleotide reductase · Nucleoside-diphosphate kinase · DCMP deaminase · Thymidylate synthase · Dihydrofolate reductase
|
|
|
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mt, k, c/g/r/p/y/i, f/h/s/l/o/e, a/u, n, m
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k, cgrp/y/i, f/h/s/l/o/e, au, n, m, epon
|
m (A16/C10), i (k, c/g/r/p/y/i, f/h/s/o/e, a/u, n, m)
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UpToDate Contents
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English Journal
- Identification of Function and Mechanistic Insights of Guanine Deaminase from Nitrosomonas europaea: Role of the C-Terminal Loop in Catalysis.
- Bitra A, Hussain B, Tanwar AS, Anand R.SourceDepartment of Chemistry, IIT Bombay , Mumbai, India 400076.
- Biochemistry.Biochemistry.2013 May 6. [Epub ahead of print]
- NE0047 from Nitrosomonas europaea has been annotated as a zinc-dependent deaminase; however, the substrate specificity is unknown because of the low level of structural similarity and sequence identity compared to other family members. In this study, the function of NE0047 was established as a guani
- PMID 23557066
- Mutations in Adenosine Deaminase-like (ADAL) Protein Confer Resistance to the Antiproliferative Agents N6-Cyclopropyl-PMEDAP and GS-9219.
- Frey CR, Andrei G, Votruba I, Cannizzaro C, Han B, Fung W, Hung M, Liu X, Geleziunas R, Fiten P, Opdenakker G, Snoeck R, Cihlar T.SourceBiology Department, Gilead Sciences, Inc., 362 Lakeside Dr., Foster City, CA 94404, U.S.A. christian.frey@gilead.com.
- Anticancer research.Anticancer Res.2013 May;33(5):1899-912.
- Background/Aim: GS 9219 is a double prodrug of antiproliferative nucleotide analog 9-(2-Phosphonylmethoxyethyl)guanine (PMEG), with potent in vivo efficacy against various hematological malignancies. This study investigates the role of adenosine deaminase-like (ADAL) protein in the intracellular act
- PMID 23645737
- Nrf2 activation is associated with Z-DNA formation in the human HO-1 promoter.
- Maruyama A, Mimura J, Harada N, Itoh K.SourceDepartment of Stress Response Science, Hirosaki University Graduate School of Medicine, 5 Zaifu-cho, Hirosaki 036-8562, Japan.
- Nucleic acids research.Nucleic Acids Res.2013 Apr 9. [Epub ahead of print]
- Using a luciferase reporter assay, we previously demonstrated that a Z-DNA-forming sequence of alternating thymine-guanine repeats in the human heme oxygenase-1 gene (HO-1) promoter is involved in nuclear factor erythroid-derived 2 (NF-E2)-related factor 2 (Nrf2)-mediated HO-1 promoter activation. H
- PMID 23571756
Japanese Journal
- β_3-adrenoceptor-mediated increased circulating transaminase levels in mice treated with its agonist BRL 37344
- Kasahara Hiroko,Muto Shin-ichi,Motokawa Yoshiyuki [他],ARISAKA Nobuhiko,KOBAYASHI Sayaka,SOUMA Shinji,KURODA Junji
- Journal of toxicological sciences 35(5), 779-784, 2010-10-01
- … The transaminase changes were not accompanied by increases in circulating levels of other hepatocellular enzymes, including guanine deaminase (GUA), glutamate dehydrogenase (GLDH), and lactate dehydrogenase (LDH), or any morphological hepatocellular injury. …
- NAID 10026669477
- Enzymatic Synthesis of 2'-Deoxyguanosine with Nucleoside Deoxyribosyltransferase-II
- Okuyama Kiyoshi,Shibuya Susumu,Hamamoto Tomoki [他],NOGUCHI Toshitada
- Bioscience, biotechnology, and biochemistry 67(5), 989-995, 2003-05-23
- … ACP) instead of natural guanine and the conversion of 2-amino-6-chloropurine-2′-deoxyriboside (ACPdR) to dGuo with bacterial adenosine deaminase. …
- NAID 110002694171
- Enhancement of Cellular Adenosine Triphosphate Levels in PC12 Cells by Extracellular Adenosine
- Fujimori Hiroyuki,Yasuda Masahiro,Pan-Hou Hidemitsu
- Biological & pharmaceutical bulletin 25(3), 307-311, 2002-03-01
- … The ATP-enhancing effect of Ado was potentiated by dipyridamole, an inhibitor of Ado uptake, or coformycin, an inhibitor of Ado deaminase. … Together these results suggest that enhancement of cellular ATP levels in PC12 cells by extracellular Ado might be acceleration of ATP synthesis through the Ado salvage system using hypoxanthine-guanine phosphoribosyltransferase rather than Ado kinase since 5′-iodotubercidin, an inhibitor of Ado kinase, had no effect on the enhancement elicited by Ado. …
- NAID 110003638692
Related Links
- an enzyme, found in liver, brain, spleen, pancreas, and kidney, that converts guanine into xanthine and ammonia.
- guan·ine de·am·i·nase [MIM*139260] a deaminase of the liver that catalyzes hydrolysis of guanine into xanthine and ammonia; the first step in purine degradation. Synonym(s): guanase, guanine aminase guanine deaminase n. A liver ...
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デアミナーゼ、脱アミノ酵素