グアニンアミノヒドロラーゼ
WordNet
- a purine base found in DNA and RNA; pairs with cytosine (同)G
Wikipedia preview
出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2017/07/21 14:47:16」(JST)
[Wiki en表示]
| GDA |
|
| Available structures |
| PDB |
Ortholog search: PDBe RCSB |
| List of PDB id codes |
|
4AQL, 3E0L, 2UZ9
|
|
|
| Identifiers |
| Aliases |
GDA, guanine deaminase, CYPIN, GUANASE, NEDASIN, Guanine deaminase, GAH |
| External IDs |
MGI: 95678 HomoloGene: 3171 GeneCards: GDA |
| Gene ontology |
| Molecular function |
• hydrolase activity
• metal ion binding
• hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds
• zinc ion binding
• guanine deaminase activity
|
| Cellular component |
• cytosol
• extracellular exosome
• intracellular
|
| Biological process |
• guanine catabolic process
• purine nucleotide catabolic process
• nucleobase-containing compound metabolic process
• nervous system development
• guanine metabolic process
|
| Sources:Amigo / QuickGO |
|
| Orthologs |
| Species |
Human |
Mouse |
| Entrez |
|
|
| Ensembl |
|
|
| UniProt |
|
|
| RefSeq (mRNA) |
NM_001242505
NM_001242506
NM_001242507
NM_004293
NM_001351571
|
|
NM_001351572
NM_001351573
|
|
|
| RefSeq (protein) |
NP_001229434
NP_001229435
NP_001229436
NP_004284
NP_001338500
|
|
NP_001338501
NP_001338502
|
|
|
| Location (UCSC) |
Chr 9: 72.11 – 72.26 Mb |
Chr 19: 21.39 – 21.47 Mb |
| PubMed search |
[1] |
[2] |
| Wikidata |
| View/Edit Human |
View/Edit Mouse |
|
Guanine deaminase also known as cypin, guanase, guanine aminase, GAH, and guanine aminohydrolase is an aminohydrolase enzyme which converts guanine to xanthine.[3][4][5] Cypin is a major cytosolic protein that interacts with PSD-95. It promotes localized microtubule assembly in neuronal dendrites.[6]
-
-
xanthine. Note nitrogen replaced with oxygen. (Ignore rotation.)
References
- ^ "Human PubMed Reference:".
- ^ "Mouse PubMed Reference:".
- ^ Hitchings GH, Falco EA (Oct 1944). "The Identification of Guanine in Extracts of Girella Nigricans: The Specificity of Guanase". Proceedings of the National Academy of Sciences of the United States of America. 30 (10): 294–7. PMC 1078714 . PMID 16578130. doi:10.1073/pnas.30.10.294.
- ^ Kalckar HM (1947). "Differential spectrophotometry of purine compounds by means of specific enzymes; studies of the enzymes of purine metabolism". J. Biol. Chem. 167 (2): 461–75. PMID 20285041.
- ^ Rabinowitz JC, Barker HA (Jan 1956). "Purine fermentation by Clostridium cylindrosporum. II. Purine transformations". The Journal of Biological Chemistry. 218 (1): 161–73. PMID 13278325.
- ^ Firestein BL, Firestein BL, Brenman JE, Aoki C, Sanchez-Perez AM, El-Husseini AE, Bredt DS (1999). "Cypin: a cytosolic regulator of PSD-95 postsynaptic targeting". Neuron. 24 (3): 659–72. PMID 10595517. doi:10.1016/S0896-6273(00)81120-4.
External links
- Guanine deaminase at the US National Library of Medicine Medical Subject Headings (MeSH)
|
|
| Purine metabolism |
| Anabolism |
| R5P→IMP: |
- Ribose-phosphate diphosphokinase
- Amidophosphoribosyltransferase
- Phosphoribosylglycinamide formyltransferase
- AIR synthetase (FGAM cyclase)
- Phosphoribosylaminoimidazole carboxylase
- Phosphoribosylaminoimidazolesuccinocarboxamide synthase
- IMP synthase
|
| IMP→AMP: |
- Adenylosuccinate synthase
- Adenylosuccinate lyase
- reverse
|
| IMP→GMP: |
- IMP dehydrogenase
- GMP synthase
- reverse
|
|
| Nucleotide salvage |
- Hypoxanthine-guanine phosphoribosyltransferase
- Adenine phosphoribosyltransferase
|
| Catabolism |
- Adenosine deaminase
- Purine nucleoside phosphorylase
- Guanine deaminase
- Xanthine oxidase
- Urate oxidase
|
|
| Pyrimidine metabolism |
| Anabolism |
- CAD
- Carbamoyl phosphate synthase II
- Aspartate carbamoyltransferase
- Dihydroorotase
|
- Dihydroorotate dehydrogenase
- Orotidine 5'-phosphate decarboxylase/Uridine monophosphate synthetase
|
|
|
|
| Catabolism |
- Dihydropyrimidine dehydrogenase
- Dihydropyrimidinase/DPYS
- Beta-ureidopropionase/UPB1
|
|
| Deoxyribonucleotides |
- Ribonucleotide reductase
- Nucleoside-diphosphate kinase
- DCMP deaminase
- Thymidylate synthase
- Dihydrofolate reductase
|
|
Hydrolases: carbon-nitrogen non-peptide (EC 3.5)
|
3.5.1: Linear amides /
Amidohydrolases |
- Asparaginase
- Glutaminase
- Urease
- Biotinidase
- Aspartoacylase
- Ceramidase
- Aspartylglucosaminidase
- Fatty acid amide hydrolase
- Histone deacetylase
|
3.5.2: Cyclic amides/
Amidohydrolases |
- Barbiturase
- Beta-lactamase
|
3.5.3: Linear amidines/
Ureohydrolases |
- Arginase
- Agmatinase
- Protein-arginine deiminase
|
3.5.4: Cyclic amidines/
Aminohydrolases |
- Guanine deaminase
- Adenosine deaminase
- AMP deaminase
- Inosine monophosphate synthase
- DCMP deaminase
- GTP cyclohydrolase I
- Cytidine deaminase
- AICDA
- Activation-induced cytidine deaminase
|
3.5.5: Nitriles/
Aminohydrolases |
|
| 3.5.99: Other |
- Riboflavinase
- Thiaminase II
|
|
Enzymes
|
| Activity |
- Active site
- Binding site
- Catalytic triad
- Oxyanion hole
- Enzyme promiscuity
- Catalytically perfect enzyme
- Coenzyme
- Cofactor
- Enzyme catalysis
|
| Regulation |
- Allosteric regulation
- Cooperativity
- Enzyme inhibitor
|
| Classification |
- EC number
- Enzyme superfamily
- Enzyme family
- List of enzymes
|
| Kinetics |
- Enzyme kinetics
- Eadie–Hofstee diagram
- Hanes–Woolf plot
- Lineweaver–Burk plot
- Michaelis–Menten kinetics
|
| Types |
- EC1 Oxidoreductases (list)
- EC2 Transferases (list)
- EC3 Hydrolases (list)
- EC4 Lyases (list)
- EC5 Isomerases (list)
- EC6 Ligases (list)
|
UpToDate Contents
全文を閲覧するには購読必要です。 To read the full text you will need to subscribe.
English Journal
- Differential Gel Electrophoresis (DIGE) Evaluation of Naphthoimidazoles Mode of Action: A Study in Trypanosoma cruzi Bloodstream Trypomastigotes.
- Brunoro GV1, Faça VM2, Caminha MA1,3, Ferreira AT1, Trugilho M1, de Moura KC4, Perales J1, Valente RH1, Menna-Barreto RF3.
- PLoS neglected tropical diseases.PLoS Negl Trop Dis.2016 Aug 23;10(8):e0004951. doi: 10.1371/journal.pntd.0004951. eCollection 2016.
- BACKGROUND: The obligate intracellular protozoan Trypanosoma cruzi is the causative agent of Chagas disease, a neglected illness affecting millions of people in Latin America that recently entered non-endemic countries through immigration, as a consequence of globalization. The chemotherapy for this
- PMID 27551855
- CL316243 induces phosphatidylinositol 3,4,5-triphosphate production in rat adipocytes in an adenosine deaminase-, pertussis toxin-, or wortmannin-sensitive manner.
- Ohsaka Y1, Nomura Y.
- Physiological research.Physiol Res.2016 Jul 18;65(3):543-6. Epub 2016 Mar 15.
- The effect of beta(3)-adrenoceptor (beta(3)-AR) agonists on adipocytes treated or not treated with signaling modulators has not been sufficiently elucidated. Using rat epididymal adipocytes (adipocytes) labeled with [(32)P]orthophosphate, we found that treatment with the selective beta(3)-AR agonist
- PMID 26988163
- Purine salvage in Methanocaldococcus jannaschii: Elucidating the role of a conserved cysteine in adenine deaminase.
- Miller DV1, Brown AM1, Xu H1, Bevan DR1, White RH1.
- Proteins.Proteins.2016 Jun;84(6):828-40. doi: 10.1002/prot.25033. Epub 2016 Apr 1.
- Adenine deaminases (Ade) and hypoxanthine/guanine phosphoribosyltransferases (Hpt) are widely distributed enzymes involved in purine salvage. Characterization of the previously uncharacterized Ade (MJ1459 gene product) and Hpt (MJ1655 gene product) are discussed here and provide insight into purine
- PMID 26990095
Japanese Journal
- 血清グアナーゼ活性の自動分析法に関する基礎的検討と肝・胆・すい疾患における測定
Related Links
- Definitions of guanine aminohydrolase, synonyms, antonyms, derivatives of guanine aminohydrolase, analogical dictionary of guanine aminohydrolase (English) English » English ↔ search Arabic Bulgarian Chinese Croatian ...
- ・Guanine Aminohydrolase 概念ツリー： ・酵素および補酵素 Enzymes and Coenzymes ・酵素 Enzyme ・加水分解酵素 Hydrolase ・アミノヒドロラーゼ Aminohydrolase ・グアニンデアミナーゼ Guanine Deaminase 連想検索（共起語との ...
★リンクテーブル★
[★]
- 英
- guanine aminohydrolase
- 関
- グアニンデアミナーゼ
[★]
アミノヒドロラーゼ