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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2014/06/17 20:29:20」(JST)
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| guanine deaminase |
| Identifiers |
| Symbol |
GDA |
| Entrez |
9615 |
| HUGO |
4212 |
| OMIM |
139260 |
| RefSeq |
NM_004293 |
| UniProt |
Q9Y2T3 |
| Other data |
| Locus |
Chr. 9 q21.11-21.33 |
Guanine deaminase (EC 3.5.4.3, guanase, guanine aminase, GAH, guanine aminohydrolase) is an enzyme which converts guanine to xanthine.[1][2][3]
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xanthine. Note nitrogen replaced with oxygen. (Ignore rotation.)
References
- ^ Hitchings, G.H. and Falco, E.A. (1944). "The identification of guanine in extracts of Girella nigricans. The specificity of guanase". Proc. Natl. Acad. Sci. USA 30: 294–297. doi:10.1073/pnas.30.10.294. PMC 1078714. PMID 16578130.
- ^ Kalckar, H.M. (1947). "Differential spectrophotometry of purine compounds by means of specific enzymes. III. Studies of the enzymes of purine metabolism". J. Biol. Chem. 167: 461–475.
- ^ Rabinowitz, J.C. and Barker, H.A. (1956). "Purine fermentation by Clostridium cylindrosporum. II. Purine transformations". J. Biol. Chem. 218 (1): 161–173. PMID 13278325.
External links
- Guanine deaminase at the US National Library of Medicine Medical Subject Headings (MeSH)
|
Hydrolases: carbon-nitrogen non-peptide (EC 3.5)
|
|
3.5.1: Linear amides /
Amidohydrolases |
- Asparaginase
- Glutaminase
- Urease
- Biotinidase
- Aspartoacylase
- Ceramidase
- Aspartylglucosaminidase
- Fatty acid amide hydrolase
- Histone deacetylase
|
|
3.5.2: Cyclic amides/
Amidohydrolases |
- Barbiturase
- Beta-lactamase
|
|
3.5.3: Linear amidines/
Ureohydrolases |
- Arginase
- Agmatinase
- Protein-arginine deiminase
|
|
3.5.4: Cyclic amidines/
Aminohydrolases |
- Guanine deaminase
- Adenosine deaminase
- AMP deaminase
- Inosine monophosphate synthase
- DCMP deaminase
- GTP cyclohydrolase I
- Cytidine deaminase
- AICDA
- Activation-Induced (Cytidine) Deaminase
|
|
3.5.5: Nitriles/
Aminohydrolases |
|
|
| 3.5.99: Other |
- Riboflavinase
- Thiaminase II
|
|
- B
- enzm
- 1.1
- 2
- 3
- 4
- 5
- 6
- 7
- 8
- 10
- 11
- 13
- 14
- 15-18
- 2.1
- 3.1
- 4.1
- 5.1
- 6.1-3
|
|
|
|
- Metabolism: amino acid metabolism
- nucleotide enzymes
|
|
| Purine metabolism |
| Anabolism |
| R5P→IMP: |
- Ribose-phosphate diphosphokinase
- Amidophosphoribosyltransferase
- Phosphoribosylglycinamide formyltransferase
- AIR synthetase (FGAM cyclase)
- Phosphoribosylaminoimidazole carboxylase
- Phosphoribosylaminoimidazolesuccinocarboxamide synthase
- IMP synthase
|
|
| IMP→AMP: |
- Adenylosuccinate synthase
- Adenylosuccinate lyase
- reverse
|
|
| IMP→GMP: |
- IMP dehydrogenase
- GMP synthase
- reverse
|
|
|
| Nucleotide salvage |
- Hypoxanthine-guanine phosphoribosyltransferase
- Adenine phosphoribosyltransferase
|
|
| Catabolism |
- Adenosine deaminase
- Purine nucleoside phosphorylase
- Guanine deaminase
- Xanthine oxidase
- Urate oxidase
|
|
|
| Pyrimidine metabolism |
| Anabolism |
- CAD
- Carbamoyl phosphate synthase II
- Aspartate carbamoyltransferase
- Dihydroorotase
|
|
- Dihydroorotate dehydrogenase
- Orotidine 5'-phosphate decarboxylase/Uridine monophosphate synthetase
|
|
|
|
|
|
| Catabolism |
- Dihydropyrimidine dehydrogenase
- Dihydropyrimidinase/DPYS
- Beta-ureidopropionase/UPB1
|
|
|
| Deoxyribonucleotides |
- Ribonucleotide reductase
- Nucleoside-diphosphate kinase
- DCMP deaminase
- Thymidylate synthase
- Dihydrofolate reductase
|
|
|
|
mt, k, c/g/r/p/y/i, f/h/s/l/o/e, a/u, n, m
|
k, cgrp/y/i, f/h/s/l/o/e, au, n, m, epon
|
m (A16/C10), i (k, c/g/r/p/y/i, f/h/s/o/e, a/u, n, m)
|
|
|
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English Journal
- Urine Purine Metabolite Determination by UPLC-Tandem Mass Spectrometry.
- Sun Q1.
- Methods in molecular biology (Clifton, N.J.).Methods Mol Biol.2016;1378:227-35. doi: 10.1007/978-1-4939-3182-8_24.
- Inborn errors of purine metabolism, either deficiencies of synthesis or catabolism pathways, lead to a wide spectrum of clinical presentations: urolithiasis (adenine phosphoribosyltransferase), primary immune deficiency (adenosine deaminase deficiency and purine nucleoside phosphorylase deficiency),
- PMID 26602134
- AID-associated DNA repair pathways regulate malignant transformation in a murine model of BCL6-driven diffuse large B cell lymphoma.
- Gu X1, Booth CJ2, Liu Z3, Strout MP4.
- Blood.Blood.2015 Sep 18. pii: blood-2015-02-628164. [Epub ahead of print]
- Somatic hypermutation and class switch recombination of the immunoglobulin (Ig) genes occur in germinal center (GC) B cells and are initiated through deamination of cytidine to uracil by activation-induced cytidine deaminase (AID). Resulting uracil-guanine mismatches are subsequently processed by UN
- PMID 26385350
- Inhibition of AMP deaminase as therapeutic target in cardiovascular pathology.
- Zabielska MA1, Borkowski T1, Slominska EM1, Smolenski RT2.
- Pharmacological reports : PR.Pharmacol Rep.2015 Aug;67(4):682-8. doi: 10.1016/j.pharep.2015.04.007. Epub 2015 Apr 29.
- AMP deaminase (AMPD; EC 3.5.4.6) catalyzes hydrolysis of the amino group from the adenine ring of AMP resulting in production of inosine 5'-monophosphate (IMP) and ammonia. This reaction helps to maintain healthy cellular energetics by removing excess AMP that accumulates in energy depleted cells. F
- PMID 26321268
Japanese Journal
- 酵素関係(アイソザイムを含む) グアナーゼ(GU) (広範囲 血液・尿化学検査,免疫学的検査(第7版・1)その数値をどう読むか) -- (生化学的検査(1))
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