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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2015/06/15 11:53:30」(JST)
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- 1. スティーブンス・ジョンソン症候群および中毒性表皮壊死融解症：病因、臨床症状、および診断 stevens johnson syndrome and toxic epidermal necrolysis pathogenesis clinical manifestations and diagnosis
- 2. 結核の免疫学 immunology of tuberculosis
- 3. 造血細胞移植後の移植片対腫瘍効果の生物学 biology of the graft versus tumor effect following hematopoietic cell transplantation
- 4. 発疹性（麻疹様）薬疹 exanthematous morbilliform drug eruption
- 5. 肺静脈閉塞性疾患 pulmonary veno occlusive disease
English Journal
- Modulatory effects of curcumin on apoptosis and cytotoxicity-related molecules in HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP) patients.
- Mohammadi A1, Fazeli B2, Taheri M3, Sahebkar A4, Poursina Z5, Vakili V6, Yazdi SZ7, Keramati Z8, Boostani R9, Hampson I10, Rafatpanah H11.
- Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.Biomed Pharmacother.2017 Jan;85:457-462. doi: 10.1016/j.biopha.2016.11.050. Epub 2016 Nov 25.
- Apoptosis is a universal cellular defense mechanism against viral infection. Curcumin, an anti-inflammatory phytochemical, induces apoptosis through mitochondrial and receptor-mediated pathways, as well as activation of caspase cascades. Here, we investigated the impact of supplementation with curcu
- PMID 27894665
- Killing Bacteria with Cytotoxic Effector Proteins of Human Killer Immune Cells: Granzymes, Granulysin, and Perforin.
- León DL1, Fellay I1, Mantel PY1, Walch M2.
- Methods in molecular biology (Clifton, N.J.).Methods Mol Biol.2017;1535:275-284.
- Bacterial pathogens represent a constant threat to human health that was exacerbated in recent years by a dramatic increase of strains resistant to last resort antibiotics. The immune system of higher vertebrates generally evolved several efficient innate and adaptive mechanisms to fight ubiquitous
- PMID 27914086
- Clinicopathologic analysis of atypical hand, foot, and mouth disease in adult patients.
- Second J1, Velter C2, Calès S3, Truchetet F3, Lipsker D2, Cribier B2.
- Journal of the American Academy of Dermatology.J Am Acad Dermatol.2016 Dec 24. pii: S0190-9622(16)30996-3. doi: 10.1016/j.jaad.2016.10.022. [Epub ahead of print]
- BACKGROUND: Hand, foot, and mouth disease is a contagious viral infection usually affecting children. A resurgence of cases in adults, mainly caused by coxsackievirus A6 and with an atypical and more severe presentation, has taken place.OBJECTIVE: The goal was to examine the clinical, histologic, an
- PMID 28027826
Japanese Journal
- Serum granulysin levels as a predictor of serious telaprevir-induced dermatological reactions
- Hepatology research 45(8), 837-845, 2015-08
- NAID 120005820706
- Effects of interaction between genetic variants in human leukocyte antigen DQ and granulysin genes in Chinese Han subjects infected with hepatitis B virus
- Microbiology and immunology 59(4), 209-218, 2015-04
- NAID 40020440552
- 牛白血病ウイルスに感染した黒毛和種牛の臨床例における免疫状態
- 日本獣医師会雑誌 67(5), 328-332, 2014
- NAID 130004640758
Related Links
- Granulysin is a substance released by cytotoxic T cells (CD8) when they are attached to infected body cells. It functions to create holes in the target cell membrane and destroy it. Granulysin is able to induce apoptosis in target cells ...
Related Pictures
★リンクテーブル★
| リンク元 | 「キラーT細胞」 |
「キラーT細胞」
- 英
- killer T cell
- 同
- 細胞傷害性T細胞 cytotoxic T cell 、細胞溶解性T細胞 cytolytic T cell、細胞傷害性Tリンパ球 cytotoxic T lymphocyte CTL、細胞溶解性Tリンパ球 cytolytic T lymphocyte CTL
- 関
- ヘルパーT細胞、T細胞、ラック細胞 LAK細胞
- 同
- KT
- 偏性細胞内寄生体であるウイルス感染において特に誘導されやすい (SMB.47)
機能
- キラーT細胞のTCRが、抗原を提示しているMHC class Iを認識し、キラーT細胞のCD8がMHC class Iとの結合を増強して、細胞傷害を行う (SP.250)
- 攻撃の方法は２つあり、リソソームから酵素を注入する方法と、パーフォリン(perforin)を注入する方法とがある (SP.250)
抗原認識と細胞傷害 (SMB.48)
- 1. キラーT細胞のTCRがが抗原を提示したMHC class Iを認識
- 2. CD8がMHC class Iに結合
- 3. キラーT細胞で発現しているLFA-1が標的細胞のICAM-1と結合
- 4. キラーT細胞がFasリガンドを発現し、標的細胞のFasに結合
- 5. パーフォリンが放出される
- 6. グランザイムが注入される
新しいトピック
- グラニュライシン, granulysin (SMB.48)
- 結核菌の殺傷に関与
-細胞傷害性T細胞