granulosa cell tumor

顆粒膜細胞腫

WordNet

1. small room in which a monk or nun lives (同)cubicle
2. a device that delivers an electric current as the result of a chemical reaction (同)electric cell
3. a room where a prisoner is kept (同)jail cell, prison cell
4. (biology) the basic structural and functional unit of all organisms; they may exist as independent units of life (as in monads) or may form colonies or tissues as in higher plants and animals
5. any small compartment; "the cells of a honeycomb"
6. a small unit serving as part of or as the nucleus of a larger political movement (同)cadre
7. an abnormal new mass of tissue that serves no purpose (同)tumour, neoplasm

PrepTutorEJDIC

1. (刑務所の)『独房』;(修道院の)小さい独居室 / (ミツバチの)みつ房,巣穴 / 小さい部屋 / 『細胞』 / 電池 / 花粉室 / (共産党などの)細胞

Wikipedia preview

出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2014/09/18 15:25:15」(JST)

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Granulosa cell tumour
Classification and external resources
Micrograph of a juvenile granulosa cell tumour with hyaline globules. H&E stain.
ICD-10	C56
ICD-9	236.2 183 236.2
ICD-O:	8620
eMedicine	med/928
MeSH	D006106

Granulosa cell tumours (or granulosa-theca cell tumours) are tumours that arise from granulosa cells. These tumours are part of the sex cord-gonadal stromal tumour or non-epithelial group of tumours. Although granulosa cells normally occur only in the ovary, granulosa cell tumours occur in both ovaries and testicles (see Ovarian cancer and Testicular cancer). These tumours should be considered malignant and treated in the same way as other malignant tumours of ovary. The staging system for these tumours is the same as for epithelial tumours and most present as stage I. The peak age at which they occur is 50–55 years, but they may occur at any age.

Juvenile granulosa cell tumour is a similar but distinct rare tumour. It too occurs in both the ovary and testis. In the testis it is extremely rare, and has not been reported to be malignant. Although this tumour usually occurs in children (hence its name), it has been reported in adults.

Clinical presentation

Estrogens are produced by functioning tumours, and the clinical presentation depends on the patient's age and sex.

• Female
  • If the patient is postmenopausal, she usually presents with abnormal uterine bleeding.
  • If the patient is of reproductive age, she would present with menometrorrhagia. However, in some cases she may stop ovulating altogether.
  • If the patient has not undergone puberty, early onset of puberty may be seen.

• Male

Gene defect

Using next generation DNA sequencing, it was discovered that 97% of granulosa cell tumours contain an identical mutation in the FOXL2 gene [1]. This is a somatic mutation meaning it is not usually transmitted to descendants. It is believed that this mutation may be the cause of granulosa cell tumours.

Tumor marker

Inhibin, a hormone, has been used as tumor marker for granulosa cell tumor.

Gross appearance

Tumors vary in size, from tiny spots to large masses, with an average of 10 cm in diameter. Tumors are oval and soft in consistency. On cut-section, histology reveals reticular, trabecular areas with interstitial haemorrhage and Call-Exner bodies-small cyst like spaces interspersed within a graafian follicle.

Granulosa cell clusters in other species

In the ovaries of aging squirrel monkeys (Saimiri sciureus), clusters of granulosa cells occur that resemble granulosa cell tumours in humans. These appear to be a normal change with age in this species.

See also

• Inhibin, alpha

References

External links

• -46858173 at GPnotebook
• Photo of tumor
• Slides
• indiandoctors.com
• Juvenile granulosa cell tumor HP:7794 at humpath.com
• Granulosa Cell Tumour Research Foundation

UpToDate Contents

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• 1. 卵巣の性索間質腫瘍：顆粒膜-間質細胞腫瘍 sex cord stromal tumors of the ovary granulosa stromal cell tumors
• 2. 卵巣の性索間質腫瘍の概要 overview of sex cord stromal tumors of the ovary
• 3. 精巣腫瘍の解剖学および病理 anatomy and pathology of testicular tumors
• 4. 卵巣胚細胞腫瘍：病理学、臨床症状、および診断 ovarian germ cell tumors pathology clinical manifestations and diagnosis
• 5. 卵巣の性索間質腫瘍：顆粒膜細胞腫瘍およびセルトリ・ライディック細胞腫 sex cord stromal tumors of the ovary tumors with granulosa and sertoli leydig elements

English Journal

• Adult granulosa cell tumor presenting as metastases to the pleural and peritoneal cavity.

• Gupta N, Rajwanshi A, Dey P, Suri V.SourceDepartment of Cytology and Gynecological Pathology, Postgraduate Institute of Medical Education and Research, Chandigarh, India. nalini203@rediffmail.com.
• Diagnostic cytopathology.Diagn Cytopathol.2012 Oct;40(10):912-5. doi: 10.1002/dc.21675. Epub 2011 May 26.
• Ovarian tumors of sex-cord stromal derivation rarely exfoliate malignant cells in serous effusions. Adult granulosa cell tumor (AGCT) often presents as a stage I disease and association with ascites is about 10%. AGCT is rarely known to exfoliate tumor cells in the ascitic fluid. Exfoliation of mali
• PMID 21618710

• Expression and effect of fibroblast growth factor 9 in bovine theca cells.

• Schreiber NB, Totty ML, Spicer LJ.SourceDepartment of Animal Science, Oklahoma State University, 114 Animal Science Building, Stillwater, Oklahoma 74078, USA.
• The Journal of endocrinology.J Endocrinol.2012 Oct;215(1):167-75. Epub 2012 Aug 7.
• Fibroblast growth factor 9 (FGF9) protein affects granulosa cell (GC) function but is mostly localized to theca cell (TC) and stromal cell of rat ovaries. The objectives of this study were to determine the 1) effects of FGF9 on TC steroidogenesis, gene expression, and cell proliferation; 2) mechanis
• PMID 22872763

Japanese Journal

• 症例報告 初回治療後10年を経て肝臓に再発した卵巣顆粒膜細胞腫の1例

• 中西 恵美,中西 美紗緒,箕浦 茂樹 [他]
• 東京産科婦人科学会会誌 64(3), 431-436, 2015-07
• NAID 40020576993

• 症例報告 画像診断に苦慮したホルモン産生卵巣腫瘍の1例

• 清久 里菜,幾石 尚美,野坂 直子 [他]
• 東京産科婦人科学会会誌 64(3), 399-403, 2015-07
• NAID 40020576852

• A recurrent granulosa cell tumor of the ovary 25 years after the initial diagnosis: A case report

• Fujita Fumihiko,Eguchi Susumu,Takatsuki Mitsuhisa,Kobayashi Kazuma,Kanetaka Kengo,Ito Masahiro,Abe Kuniko,Kuroki Tamotsu
• International Journal of Surgery Case Reports 12, 7-10, 2015-05-07
• … Introduction Granulosa cell tumors (GCTs) are rare functional sex-cord-stromal ovarian neoplasms characterized by low malignancy potential and late relapse, which rarely metastasize to the liver. … A diagnostic laparoscopy was performed, and the biopsy specimen was histologically proven to be a recurrent granulosa cell tumor. …
• NAID 120005615575

Related Links

• Granulosa cell tumour - Wikipedia, the free encyclopedia

Granulosa cell tumours (or granulosa-theca cell tumours) are tumours that arise from granulosa cells. These tumours are part of the sex cord-gonadal stromal tumour or non-epithelial group of tumours. Although granulosa cells normally occur ...

• Recent Advances in Granulosa Cell Tumor Ovary: A Review - Springer

1 Mar 2013 ... Granulosa cell tumors constitute less than 5 % of all ovarian tumors. Unlike epithelial ovarian tumors, they occur in a younger age group, are usually detected in an early stage and often have features of hyperestrogenism.

Related Pictures

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★リンクテーブル★

リンク元	「顆粒膜細胞腫」「顆粒膜細胞腫瘍」
関連記事	「tumor」「cell」「granulosa」

「顆粒膜細胞腫」

　　[★]

英

granulosa cell tumor

関

卵巣腫瘍、性索間質性腫瘍

概念

• エストロゲンを産生　→　不正性器出血

病理

• H-E染色：コーヒー豆様の核をもつ細胞の小濾胞状配列、Call-Exner小体

検査

• 画像検査

• MRI

• T1：高信号(充実性腫瘍)
• T2：高信号(充実性腫瘍)

国試

• 100A043

「顆粒膜細胞腫瘍」

　　[★]

英

granulosa cell tumor

同

濾胞腫 folliculoma

「tumor」

　　[★]

• n.

• 腫瘍、腫瘤、腫脹

　

「cell」

　　[★] 細胞 　 　 　 　 　 　 　

「granulosa」

　　[★]

顆粒膜

関

granulosum