WordNet

act so as to bring into existence; "effect a change"
a symptom caused by an illness or a drug; "the effects of sleep loss"; "the effect of the anesthetic"
(of a law) having legal validity; "the law is still in effect" (同)force
the central meaning or theme of a speech or literary work (同)essence, burden, core, gist
an impression (especially one that is artificial or contrived); "he just did it for effect"
produce; "The scientists set up a shock wave" (同)effectuate, set_up
cause to grow together parts from different plants; "graft the cherry tree branch onto the plum tree" (同)engraft, ingraft
the act of grafting something onto something else (同)grafting
(surgery) tissue or organ transplanted from a donor to a recipient; in some cases the patient can be both donor and recipient (同)transplant
malignant neoplasm of blood-forming tissues; characterized by abnormal proliferation of leukocytes; one of the four major types of cancer (同)leukaemia, leucaemia, cancer of the blood
property of a personal character that is portable but not used in business; "she left some of her personal effects in the house"; "I watched over their effects until they returned" (同)personal_effects

PrepTutorEJDIC

〈C〉〈U〉『結果』 / 〈C〉〈U〉(…への)『効果』,効きめ,影響《+『on』(『upon』)+『名』》 / 〈C〉(色・音・形などの)印象,感銘 / 《複数形で》品物;身の回り品;動産,財産 / (結果として)…‘を'『もたらす』;〈目的など〉‘を'果たす,遂行する
(つぎ木の)つぎ穂;つぎ木 / (皮被・内臓・骨などの)移植片 / (木に)〈つぎ穂〉‘を'つぐ,(体に)〈移植片〉‘を'移植する《+『名』+『on』(『upon』,『in』,『into』)+『名』》 / …‘を'結合させる《+『名』+『together』》 / (…に)つぎ木する,移植する《+『on』(『upon』,『in』,『into』)+『名』》
収賄,汚職;贈賄;〈C〉汚職で得たもの / 汚職する,収賄する
(訴訟・競技などで)…対(《略》v.,vs.)(against) / (比較や二者択一において)…に対して
白血病

Wikipedia preview

出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2016/03/30 12:55:01」(JST)

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Graft versus tumor effect (GvT) appears after allogeneic hematopoietic stem cell transplantation (HSCT). The graft contains donor T lymphocytes that are beneficial for recipient. Donor T-cells eliminate malignant residual host T-cells (graft versus leukemia) or eliminates diverse kinds of tumors.^[1] GvT might develop after recognizing tumor-specific or recipient-specific alloantigens.[99] It could lead to remission or immune control of hematologic malignancies.^[2] This effect applies in myeloma and lymphoid leukemias, lymphoma, multiple myeloma and possibly breast cancer.^[3] It is closely linked with graft versus host disease phenoma (GvHD). CD4+CD25+ regulatory T cells (Treg) can be used to suppress GvHD without loss of beneficial GvT effect.^[4] The biology of GvT response still isn’t fully understood but it is probable that the reaction with polymorphic minor histocompatibility antigens expressed either specifically on hematopoietic cells or more widely on a number of tissue cells or tumor-associated antigens is involved.^[5]^[6] This response is mediated largely by cytotoxic T lymphocytes (CTL) but it can be employed by natural killers (NK cells) as separate effectors, particularly in T-cell-depleted HLA-haploidentical HSCT.^[6]

References

^ Thompson LF, Tsukamoto H, Chernogorova P, Zeiser R (2013). "A delicate balance: CD73-generated adenosine limits the severity of graft vs. host disease but also constrains the allogeneic graft vs. tumor effect". Oncoimmunology 2 (1): e22107. doi:10.4161/onci.22107. PMC 3583907. PMID 23482243.
^ Kolb HJ (2008). "Graft-versus-leukemia effects of transplantation and donor lymphocytes". Blood 112 (12): 4371–83. doi:10.1182/blood-2008-03-077974. PMID 19029455.
^ Childs RW, Clave E, Tisdale J, Plante M, Hensel N, Barrett J (1999). "Successful treatment of metastatic renal cell carcinoma with a nonmyeloablative allogeneic peripheral-blood progenitor-cell transplant: evidence for a graft-versus-tumor effect". J Clin Oncol 17 (7): 2044–9. PMID 10561256.
^ Vagianos C, Polydorou A, Karatzas T, Vagenas C, Stavropoulos M, Androulakis J (1992). "Successful treatment of postoperative external biliary fistula by selective nasobiliary drainage". HPB Surg 6 (2): 115–20; discussion 120–4. doi:10.1155/1992/58436. PMC 2443016. PMID 1292584.
^ Baron F, Maris MB, Sandmaier BM, Storer BE, Sorror M, Diaconescu R, et al. (2005). "Graft-versus-tumor effects after allogeneic hematopoietic cell transplantation with nonmyeloablative conditioning". J Clin Oncol 23 (9): 1993–2003. doi:10.1200/JCO.2005.08.136. PMID 15774790.
^ ^a ^b Rezvani AR, Storb RF (2008). "Separation of graft-vs.-tumor effects from graft-vs.-host disease in allogeneic hematopoietic cell transplantation". J Autoimmun 30 (3): 172–9. doi:10.1016/j.jaut.2007.12.002. PMC 2329571. PMID 18242060.

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1. 造血細胞移植後の移植片対腫瘍効果の生物学 biology of the graft versus tumor effect following hematopoietic cell transplantation
2. 急性移植片対宿主病の予防 prevention of acute graft versus host disease
3. 成人における急性リンパ芽球性白血病に対する造血細胞移植の一般原則 general principles of hematopoietic cell transplantation for acute lymphoblastic leukemia in adults
4. 慢性リンパ性白血病における造血細胞移植 hematopoietic cell transplantation in chronic lymphocytic leukemia
5. 若年成人における急性骨髄性白血病に対する寛解後療法 post remission therapy for acute myeloid leukemia in younger adults

English Journal

Suppression of graft-versus-host disease and retention of graft-versus-tumour reaction by murine genetically engineered dendritic cells following bone marrow transplantation.

Huang Y1, Feng S2, Xu Y1, Chen W1, Wang S1, Li D1, Li Z1, Lu Q1, Pan X1, Xu K1.
Molecular medicine reports.Mol Med Rep.2015 May;11(5):3820-7. doi: 10.3892/mmr.2014.3123. Epub 2014 Dec 22.
The effect of infusion of lentiviral vector‑mediated, genetically engineered dendritic cells (DCs) following allogeneic bone marrow transplantation (allo‑BMT) on graft‑versus‑host disease (GVHD) and graft‑versus‑leukemia (GVL) was investigated in a mouse model. Lentivirus‑mediated expr
PMID 25529231

Comparison of Conditioning Regimens with or without Antithymocyte Globulin for Unrelated Cord Blood Transplantation in Children with High-Risk or Advanced Hematological Malignancies.

Zheng C1, Luan Z2, Fang J3, Sun X4, Chen J5, Li CK6, Hu S7, Zhu Y8, Sun Z1.
Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation.Biol Blood Marrow Transplant.2015 Apr;21(4):707-12. doi: 10.1016/j.bbmt.2014.12.023. Epub 2015 Jan 15.
The role and potential efficacy of antithymocyte globulin (ATG) in patients receiving cord blood transplantation (CBT) remain controversial. We retrospectively evaluated the effect of ATG on patient outcomes in 207 children with high-risk or advanced hematological malignancies at 8 child blood disea
PMID 25598277

Can a female donor for a male recipient decrease the relapse rate for patients with acute myeloid leukemia treated with allogeneic hematopoietic stem cell transplantation?

Kongtim P1, Di Stasi A1, Rondon G1, Chen J1, Adekola K1, Popat U1, Oran B1, Kebriaei P1, Andersson BS1, Champlin RE1, Ciurea SO2.
Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation.Biol Blood Marrow Transplant.2015 Apr;21(4):713-9. doi: 10.1016/j.bbmt.2014.12.018. Epub 2014 Dec 23.
The mismatched minor histocompatibility antigens present on Y chromosome (H-Y) in male recipients receiving stem cells from female donors may contribute to the graft-versus-leukemia effect and results in a reduced relapse rate, especially in patients with high-risk disease. We retrospectively compar
PMID 25540936