graded dilator

出典: meddic


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英文文献

  • Neuromodulator-evoked synaptic metaplasticity within a central pattern generator network.
  • Kvarta MD, Harris-Warrick RM, Johnson BR.Author information Department of Neurobiology and Behavior, S. G. Mudd Hall, Cornell University, Ithaca, New York 14853, USA.AbstractSynapses show short-term activity-dependent dynamics that alter the strength of neuronal interactions. This synaptic plasticity can be tuned by neuromodulation as a form of metaplasticity. We examined neuromodulator-induced metaplasticity at a graded chemical synapse in a model central pattern generator (CPG), the pyloric network of the spiny lobster stomatogastric ganglion. Dopamine, serotonin, and octopamine each produce a unique motor pattern from the pyloric network, partially through their modulation of synaptic strength in the network. We characterized synaptic depression and its amine modulation at the graded synapse from the pyloric dilator neuron to the lateral pyloric neuron (PD→LP synapse), driving the PD neuron with both long square pulses and trains of realistic waveforms over a range of presynaptic voltages. We found that the three amines can differentially affect the amplitude of graded synaptic transmission independently of the synaptic dynamics. Low concentrations of dopamine had weak and variable effects on the strength of the graded inhibitory postsynaptic potentials (gIPSPs) but reliably accelerated the onset of synaptic depression and recovery from depression independently of gIPSP amplitude. Octopamine enhanced gIPSP amplitude but decreased the amount of synaptic depression; it slowed the onset of depression and accelerated its recovery during square pulse stimulation. Serotonin reduced gIPSP amplitude but increased the amount of synaptic depression and accelerated the onset of depression. These results suggest that amine-induced metaplasticity at graded chemical synapses can alter the parameters of synaptic dynamics in multiple and independent ways.
  • Journal of neurophysiology.J Neurophysiol.2012 Nov;108(10):2846-56. doi: 10.1152/jn.00586.2012. Epub 2012 Aug 29.
  • Synapses show short-term activity-dependent dynamics that alter the strength of neuronal interactions. This synaptic plasticity can be tuned by neuromodulation as a form of metaplasticity. We examined neuromodulator-induced metaplasticity at a graded chemical synapse in a model central pattern gener
  • PMID 22933725
  • Determination of prognostic factors for vaginal mucosal toxicity associated with intravaginal high-dose rate brachytherapy in patients with endometrial cancer.
  • Bahng AY, Dagan A, Bruner DW, Lin LL.Author information Department of Radiation Oncology, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA.AbstractPURPOSE: The objective of this study was to determine the patient- and treatment-related prognostic factors associated with vaginal toxicity in patients who received intravaginal high dose rate (HDR) brachytherapy alone as adjuvant treatment for endometrial cancer. Secondary goals of this study included a quantitative assessment of optimal dilator use frequency and a crude assessment of clinical predictors for compliant dilator use.
  • International journal of radiation oncology, biology, physics.Int J Radiat Oncol Biol Phys.2012 Feb 1;82(2):667-73. doi: 10.1016/j.ijrobp.2010.10.071. Epub 2011 Feb 6.
  • PURPOSE: The objective of this study was to determine the patient- and treatment-related prognostic factors associated with vaginal toxicity in patients who received intravaginal high dose rate (HDR) brachytherapy alone as adjuvant treatment for endometrial cancer. Secondary goals of this study incl
  • PMID 21300451
  • Peptide neuromodulation of synaptic dynamics in an oscillatory network.
  • Zhao S, Sheibanie AF, Oh M, Rabbah P, Nadim F.Author information Department of Biological Sciences, Rutgers University, Newark, New Jersey 07102, USA.AbstractAlthough neuromodulation of synapses is extensively documented, its consequences in the context of network oscillations are not well known. We examine the modulation of synaptic strength and short-term dynamics in the crab pyloric network by the neuropeptide proctolin. Pyloric oscillations are driven by a pacemaker group which receives feedback through the inhibitory synapse from the lateral pyloric (LP) to pyloric dilator (PD) neurons. We show that proctolin modulates the spike-mediated and graded components of the LP to PD synapse. Proctolin enhances the graded component and unmasks a surprising heterogeneity in its dynamics where there is depression or facilitation depending on the amplitude of the voltage waveform of the presynaptic LP neuron. The spike-mediated component is influenced by the baseline membrane potential and is also enhanced by proctolin at all baseline potentials. In addition to direct modulation of this synapse, proctolin also changes the shape and amplitude of the presynaptic voltage waveform which additionally enhances synaptic output during ongoing activity. During ongoing oscillations, proctolin reduces the variability of cycle period but only when the LP to PD synapse is functionally intact. Using the dynamic clamp technique we find that the reduction in variability is a direct consequence of modulation of the LP to PD synapse. These results demonstrate that neuromodulation of synapses involves complex and interacting influences that target different synaptic components and dynamics as well as the presynaptic voltage waveform. At the network level, modulation of feedback inhibition can result in reduction of variability and enhancement of stable oscillatory output.
  • The Journal of neuroscience : the official journal of the Society for Neuroscience.J Neurosci.2011 Sep 28;31(39):13991-4004. doi: 10.1523/JNEUROSCI.3624-11.2011.
  • Although neuromodulation of synapses is extensively documented, its consequences in the context of network oscillations are not well known. We examine the modulation of synaptic strength and short-term dynamics in the crab pyloric network by the neuropeptide proctolin. Pyloric oscillations are drive
  • PMID 21957260

関連リンク

These dilators are medically graded (FDA INT), non-toxic and latex-free. Highly effective for post-surgical recovery programs as well as for treating vaginismus, dyspareunia, vaginal narrowing and other similar gynecological Can I ...
1. Am J Gastroenterol. 1993 Jan;88(1):34-8. Graded pneumatic dilation using Rigiflex achalasia dilators in patients with primary esophageal achalasia. Kadakia SC, Wong RK. Pneumatic dilation is the initial therapy for primary ...

関連画像

 image details dilator set dilator setCervical Dilators - Francis & Co, circa Cook Dilator System and Kolenda Introducer Vaginal Dilator Set #T8077Marchal Dilator System includes set of FIGURE 20-1. A: Tapered polyvinyl dilators


★リンクテーブル★
先読み腟痙」「androgen insensitivity syndrome
関連記事grade」「dilator」「graded」「grad

腟痙」

  [★]

vaginism
vaginismus
ワギニスム腟痙攣
膣痙




androgen insensitivity syndrome」

  [★] 精巣性女性化症候群

grade」

  [★]

  • n.
  • v.
  • 類別する
degreeextentgradingmeasurephasestagestep

WordNet   license wordnet

「level to the right gradient」

WordNet   license wordnet

「a relative position or degree of value in a graded group; "lumber of the highest grade"」
level, tier

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「the height of the ground on which something stands; "the base of the tower was below grade"」
ground level

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「a variety of cattle produced by crossbreeding with a superior breed」

WordNet   license wordnet

「the gradient of a slope or road or other surface; "the road had a steep grade"」

WordNet   license wordnet

「a degree of ablaut」
gradation

PrepTutorEJDIC   license prepejdic

「《米》(小・中・高校の)『学年』(小学校から12年まで通算する) / 《おもに米》(学業の)『成績』,評点 / (位階・品質・価値などの)『階級』,『等級』 / 《米》(道路・線路などの)傾斜,勾配(こうばい)(《英》gradient) / …‘を'『等級分けする』,‘の'格づけをする / 《米》…‘の'採点をする / 〈道路など〉‘の'勾配(こうばい)をゆるくする / 等級別になる,徐々に変わる,〈色彩などが〉次第に他の色に移る」

WordNet   license wordnet

「assign a grade or rank to, according to one''s evaluation; "grade tests"; "score the SAT essays"; "mark homework"」
score, mark

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「determine the grade of or assign a grade to」


dilator」

  [★]

  • n.

WordNet   license wordnet

「a surgical instrument that is used to dilate or distend an opening or an organ」
dilater

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「a drug that causes dilation」

WordNet   license wordnet

「a muscle or nerve that dilates or widens a body part」

graded」

  [★]

  • adj.
  • 段階的な、計量的な
quantitativestepwisestepwisely

WordNet   license wordnet

「arranged in a sequence of grades or ranks; "stratified areas of the distribution"」
ranked, stratified

grad」

  [★]

WordNet   license wordnet

「one-hundredth of a right angle」
grade

PrepTutorEJDIC   license prepejdic

「(大学の)卒業生」



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