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1. 慢性腎疾患関連眼疾患 eye disorders associated with chronic kidney disease
2. 小児における再発性腎結石症の予防 prevention of recurrent nephrolithiasis in children
3. 小児における腎結石症の疫学および危険因子 epidemiology of and risk factors for nephrolithiasis in children
4. メタノールおよびエチレングリコール中毒 methanol and ethylene glycol poisoning

English Journal

Synthesis and anti-biofilm activities of dihydro-pyrrol-2-one derivatives on Pseudomonas aeruginosa.

Ye Y1, Fang F2, Li Y2.
Bioorganic & medicinal chemistry letters.Bioorg Med Chem Lett.2015 Feb 1;25(3):597-601. doi: 10.1016/j.bmcl.2014.12.010. Epub 2014 Dec 13.
Biofilm formation is an important reason for bacterial resistance to antimicrobials. Many compounds with dihydro-pyrrol-2-one (DPO) have antibacterial effects. It is prospective to base on DPO skeleton to design new compounds for biofilm inhibition. DPO was designed by a novel method of tandem cycli
PMID 25537269

Copper(I)-Catalyzed Three-Component Reaction of Terminal Propargyl Alcohols, Aldehydes, and Amines: Synthesis of 3-Amino-2-pyrones and 2,5-Dihydrofurans.

Fan W1, Ma S.
Angewandte Chemie (International ed. in English).Angew Chem Int Ed Engl.2014 Dec 22;53(52):14542-5. doi: 10.1002/anie.201408826. Epub 2014 Oct 29.
A novel copper(I)-catalyzed three-component reaction for the efficient synthesis of 3-amino-2-pyrones and 2,5-dihydrofurans from propargyl alcohols, aldehydes, and amines has been developed. The starting materials are easily available and the scope of this method is broad. Through mechanistic studie
PMID 25353157

Desilylative activation of TMSCN in chemoselective Strecker-Ugi type reaction: functional fused imidazoles as building blocks as an entry route to annulated purines.

Guchhait SK1, Chaudhary V.
Organic & biomolecular chemistry.Org Biomol Chem.2014 Sep 14;12(34):6694-705. doi: 10.1039/c4ob00882k.
A pathway of desilylative activation of TMSCN as a functional isonitrile equivalent, and DABCO-THF as an appropriate system for activation in a chemoselective Strecker-Ugi type reaction, has rendered ethyl glyoxalate and various heterocyclic-2-amidines as feasible substrates, and afforded the succes
PMID 25032666

Production of L-Serine from Methanol and Glycine by Resting Cells of a Methylotroph under Automatically Controlled Conditions

SIRIROTE PRAMOTE,YAMANE TSUNEO,SHIMIZU SHOICHI
Journal of fermentation technology 64(5), 389-396, 1986-10-25
… Serine glyoxalate aminotransferase was not completely inhibited by the high concentration of glycine (about 68% of synthesized L-serine was detected in the supernatant). …
NAID 110002673012

小川由英
日本泌尿器科學會雜誌 73(8), 971-976, 1982-08-20
血漿蓚酸測定の感度を上げる目的で,Bennettらの方法に改良を加えた。血漿を限外濾過法で除蛋白し,その5ml中の蓚酸を沈澱および抽出により精製し,酵素反応を行なつた。その反応系を0.2mlと縮小し,測定限界を無水蓚酸の絶対量0.3μgとすることが出来た。この方法で測定した健康人15人の空腹時血漿蓚酸値の平均は15.9±10.8μmol/ι(SD)であり,結万患者15人の平均は27.6土7.2μm …
NAID 110003055737

安光勉
結核 48(6), 227-233, 1973
… β-aminoxyalanine and glyoxalate was incubated with rat liver extract, and the enzyme product was purified using ion exchange chromatography to isolate a crystalline material. … This was a shiff base of β-aminoxy-alanine and glyoxalate. …
NAID 130001415899