glycosylphosphatidylinositol anchor

グリコシルホスファチジルイノシトールアンカー

関

glycosyl-phosphatidylinositol、glycosylphosphatidylinositol

WordNet

1. a mechanical device that prevents a vessel from moving (同)ground tackle
2. fix firmly and stably; "anchor the lamppost in concrete" (同)ground
3. a television reporter who coordinates a broadcast to which several correspondents contribute (同)anchorman, anchorperson
4. a central cohesive source of support and stability; "faith is his anchor"; "the keystone of campaign reform was the ban on soft money"; "he is the linchpin of this firm" (同)mainstay, keystone, backbone, linchpin, lynchpin
5. secure a vessel with an anchor; "We anchored at Baltimore" (同)cast anchor, drop anchor

PrepTutorEJDIC

1. 『いかり』(錨) / (いかりのような)固定装置 / 頼みの綱 / (またanchorman)リレーの最終走者(泳者),アンカー / 〈船〉'を'いかりで留める,停泊させる / (一般に)(…に)…'を'留める,固定する《+『名』+『to』+『名』》 / (…に)〈希望など〉'を'つなぐ《+『名』+『in』(『on』)+『名』》 / 〈船が〉いかりを降ろして停泊する;〈人が〉いかりを降ろして船を停泊させる

UpToDate Contents

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• 1. 発作性夜間血色素尿症の病因pathogenesis of paroxysmal nocturnal hemoglobinuria [show details]
  …shortened lifespan. In MCAHS2, the GPI anchor protein deficiency is most conspicuous on granulocytes. Red blood cells (RBCs) from these patients have little to no GPI anchor deficiency and no hemolysis. …
• 2. 補体系の制御因子および受容体regulators and receptors of the complement system [show details]
  …(phosphatidylinositol glycan anchor biosynthesis, class A) that prevents the formation via a glycosylphosphatidylinositol anchor, such that CD59 is not expressed on the cell surface. This results in an increased…
• 3. 血小板減少症患者への抗凝固療法anticoagulation in individuals with thrombocytopenia [show details]
  …expansion of an abnormal clone of hematopoietic cells lacking a glycosylphosphatidylinositol (GPI) anchor, which leads to hemolysis and thrombosis. The mechanism of thrombosis is incompletely understood…
• 4. 発作性夜間血色素尿症の臨床症状および診断clinical manifestations and diagnosis of paroxysmal nocturnal hemoglobinuria [show details]
  …(partial expression of cell surface GPI anchored proteins), and type I PNH erythrocytes (normal cell surface GPI-anchor protein expression). Cells deficient in GPI-anchored proteins have also been reported …
• 5. 小児における溶血性貧血の概要overview of hemolytic anemias in children [show details]
  …erythrocyte abnormalities and external stimuli. Hemolysis occurs because glycosylphosphatidylinositol (GPI)-anchored complement inhibitors that normally protect erythrocytes from intravascular and extravascular…

English Journal

• MDGA2 is a novel tumour suppressor cooperating with DMAP1 in gastric cancer and is associated with disease outcome.

• Wang K1, Liang Q1, Li X2, Tsoi H1, Zhang J1, Wang H3, Go MY1, Chiu PW4, Ng EK4, Sung JJ1, Yu J1.
• Gut.Gut.2016 Oct;65(10):1619-31. doi: 10.1136/gutjnl-2015-309276. Epub 2015 Jul 23.
• BACKGROUND: Using the promoter methylation assay, we have shown that MDGA2 (MAM domain containing glycosylphosphatidylinositol anchor 2) is preferentially methylated in gastric cancer. We analysed its biological effects and prognostic significance in gastric cancer.METHODS: MDGA2 methylation status
• PMID 26206665

• A host cell membrane microdomain is a critical factor for organelle discharge by Toxoplasma gondii.

• Tahara M1, Andrabi SB2, Matsubara R1, Aonuma H3, Nagamune K4.
• Parasitology international.Parasitol Int.2016 Oct;65(5 Pt A):378-88. doi: 10.1016/j.parint.2016.05.012. Epub 2016 May 20.
• Host cell microdomains are involved in the attachment, entry, and replication of intracellular microbial pathogens. Entry into the host cell of Toxoplasma gondii and the subsequent survival of this protozoan parasite are tightly coupled with the proteins secreted from organelle called rhoptry. The r
• PMID 27217289

• C-Terminal-Deleted Prion Protein Fragment Is a Major Accumulated Component of Systemic PrP Deposits in Hereditary Prion Disease With a 2-Bp (CT) Deletion in PRNP Codon 178.

• Honda H1, Matsuzono K2, Fushimi S2, Sato K2, Suzuki SO2, Abe K2, Iwaki T2.
• Journal of neuropathology and experimental neurology.J Neuropathol Exp Neurol.2016 Sep 15. pii: nlw077. [Epub ahead of print]
• Prion protein (PrP) has 2 glycosylated sites and a glycosylphosphatidylinositol (GPI) anchor on the C-terminal. Reports on genetic prion disease with GPI anchorless PrP are very limited. In this study, we characterized the molecular alterations of mutated PrP in a 37-year-old female autopsy case wit
• PMID 27634965

Japanese Journal

• Tracking Neospora caninum parasites using chimera monoclonal antibodies against its surface antigen-related sequences (rNcSRS2)(CELL AND TISSUE ENGINEERING)

• Dong Jinhua,Otsuki Takahiro,Kato Tatsuya [他],Park Enoch Y.
• Journal of bioscience and bioengineering 117(3), 351-357, 2014-03
• … H3 clone bound to rNcSRS2 but not to a truncated protein without glycosylphosphatidylinositol (GPI) anchor domain in the carboxyl terminal. …
• NAID 110009815389

• Evaluation for a Mutagenicity of 4,4′-Methylenedianiline on Hematopoietic Cells by a Pig-a Gene Mutation Assay in Rats

• Sanada Hisakazu,Okamoto Minako,Ohsumi Tomoka [他],Nakamura Toshiyuki
• Genes and Environment 36(4), 179-185, 2014
• … The Pig-a gene is involved in the synthesis of glycosylphosphatidylinositol (GPI) anchors. … Pig-a gene mutations can be detected by identifying the presence of CD59, the GPI anchor protein, on the surface of erythrocytes (RBC Pig-a assay) and reticulocytes (PIGRET assay) and can be identified using flow cytometry. …
• NAID 130004695360

• Evaluation of Rats' In Vivo Genotoxicity Induced by N-ethyl-N-nitrosourea in the RBC Pig-a, PIGRET, and gpt Assays

• Horibata Katsuyoshi,Ukai Akiko,Honma Masamitsu
• Genes and Environment 36(4), 199-202, 2014
• … The emerging Pig-a gene mutation assay, a powerful and promising tool for evaluating in vivo genotoxicity, is based on flow cytometric enumeration of red blood cells (RBCs), which are deficient in glycosylphosphatidylinositol anchored protein. …
• NAID 130004685140

Related Links

• The Glycosylphosphatidylinositol Anchor: A Complex ...

Positioned at the C-terminus of many eukaryotic proteins, the glycosylphosphatidylinositol (GPI) anchor is a posttranslational modification that anchors the modified protein in the outer leaflet of the cell membrane. The ...

• Glycosylphosphatidylinositol (GPI)-anchored proteins.

1. Biol Pharm Bull. 2002 Apr;25(4):409-17. Glycosylphosphatidylinositol (GPI)-anchored proteins. Ikezawa H(1). Author information: (1)Faculty of Pharmaceutical Sciences, Nagoya City University, Aichi, Japan. QWT06005@ ...

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★リンクテーブル★

リンク元	「グリコシルホスファチジルイノシトールアンカー」
拡張検索	「glycosylphosphatidylinositol-anchored protein deficiency」「glycosylphosphatidylinositol-anchored glycoproteins」
関連記事	「anchor」「anchoring」「glycosylphosphatidylinositol」

「グリコシルホスファチジルイノシトールアンカー」

　　[★]

英

glycosylphosphatidylinositol anchor

関

グリコシルホスファチジルイノシトール

「glycosylphosphatidylinositol-anchored protein deficiency」

　　[★] グリコシルホスファチジルイノシトール結合蛋白質欠損症

「glycosylphosphatidylinositol-anchored glycoproteins」

　　[★]

同

GPI-anchored／G PI-linked

「anchor」

　　[★]

• n.

• アンカー

• v.

• 繋留する、係留する、固着させる

関

adhesion、anchoring、sessile、stick、sticking、tether

　 　 　 　 　 　

「anchoring」

　　[★]

• n.

• 繋留、係留、固着、アンカリング

関

adhesion、anchor、sessile、stick、sticking、tether

「glycosylphosphatidylinositol」

　　[★]

グリコシルホスファチジルイノシトール

関

glycosyl-phosphatidylinositol、glycosylphosphatidylinositol anchor、GPI