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出典(authority):フリー百科事典『ウィキペディア(Wikipedia)』「2016/03/11 14:33:01」(JST)
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glycolaldehyde dehydrogenase |
Identifiers |
EC number |
1.2.1.21 |
CAS number |
37250-89-8 |
Databases |
IntEnz |
IntEnz view |
BRENDA |
BRENDA entry |
ExPASy |
NiceZyme view |
KEGG |
KEGG entry |
MetaCyc |
metabolic pathway |
PRIAM |
profile |
PDB structures |
RCSB PDB PDBe PDBsum |
Gene Ontology |
AmiGO / EGO |
Search |
PMC |
articles |
PubMed |
articles |
NCBI |
proteins |
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In enzymology, a glycolaldehyde dehydrogenase (EC 1.2.1.21) is an enzyme that catalyzes the chemical reaction
- glycolaldehyde + NAD+ + H2O glycolate + NADH + 2 H+
The 3 substrates of this enzyme are glycolaldehyde, NAD+, and H2O, whereas its 3 products are glycolate, NADH, and H+.
This enzyme belongs to the family of oxidoreductases, specifically those acting on the aldehyde or oxo group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is glycolaldehyde:NAD+ oxidoreductase. This enzyme is also called glycol aldehyde dehydrogenase. This enzyme participates in glyoxylate and dicarboxylate metabolism.
Structural studies
As of late 2007, 3 structures have been solved for this class of enzymes, with PDB accession codes 2HG2, 2ILU, and 2IMP.
References
- Davies DD (1960). "The purification and properties of glycolaldehyde dehydrogenase". J. Exp. Bot. 11: 289–295. doi:10.1093/jxb/11.3.289.
Aldehyde/oxo oxidoreductases (EC 1.2)
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1.2.1: NAD or NADP |
- Aldehyde dehydrogenase
- Acetaldehyde dehydrogenase
- Long-chain-aldehyde dehydrogenase
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1.2.2: cytochrome |
- Formate dehydrogenase (cytochrome)
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1.2.3: oxygen |
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1.2.4: disulfide |
- Oxoglutarate dehydrogenase complex
- Pyruvate dehydrogenase
- Branched-chain alpha-keto acid dehydrogenase complex
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1.2.7: iron-sulfur protein |
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Proteins: enzymes
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Activity |
- Active site
- Binding site
- Catalytic triad
- Oxyanion hole
- Enzyme promiscuity
- Catalytically perfect enzyme
- Coenzyme
- Cofactor
- Enzyme catalysis
- Enzyme kinetics
- Lineweaver–Burk plot
- Michaelis–Menten kinetics
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Regulation |
- Allosteric regulation
- Cooperativity
- Enzyme inhibitor
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Classification |
- EC number
- Enzyme superfamily
- Enzyme family
- List of enzymes
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Types |
- EC1 Oxidoreductases(list)
- EC2 Transferases(list)
- EC3 Hydrolases(list)
- EC4 Lyases(list)
- EC5 Isomerases(list)
- EC6 Ligases(list)
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UpToDate Contents
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English Journal
- Enzyme Architecture: A Startling Role for Asn270 in Glycerol 3-Phosphate Dehydrogenase-Catalyzed Hydride Transfer.
- Reyes AC1, Amyes TL1, Richard JP1.
- Biochemistry.Biochemistry.2016 Mar 15;55(10):1429-32. doi: 10.1021/acs.biochem.6b00116. Epub 2016 Mar 3.
- The side chains of R269 and N270 interact with the phosphodianion of dihydroxyacetone phosphate (DHAP) bound to glycerol 3-phosphate dehydrogenase (GPDH). The R269A, N270A, and R269A/N270A mutations of GPDH result in 9.1, 5.6, and 11.5 kcal/mol destabilization, respectively, of the transition state
- PMID 26926520
- Haemophilus influenzae strains possess variations in the global transcriptional profile in response to oxygen levels and this influences sensitivity to environmental stresses.
- Jiang D1, Tikhomirova A1, Kidd SP2.
- Research in microbiology.Res Microbiol.2016 Jan;167(1):13-9. doi: 10.1016/j.resmic.2015.08.004. Epub 2015 Sep 8.
- An alcohol dehydrogenase, AdhC, is required for Haemophilus influenzae Rd KW20 growth with high oxygen. AdhC protects against both exogenous and metabolically generated, endogenous reactive aldehydes. However, adhC in the strain 86-028NP is a pseudogene. Unlike the Rd KW20 adhC mutant, 86-028NP does
- PMID 26362945
- Optimization of ethylene glycol production from (D)-xylose via a synthetic pathway implemented in Escherichia coli.
- Alkim C1,2,3,4, Cam Y5,6,7,8, Trichez D9,10,11, Auriol C12,13,14,15, Spina L16,17,18, Vax A19,20,21, Bartolo F22, Besse P23, François JM24,25,26,27, Walther T28,29,30,31.
- Microbial cell factories.Microb Cell Fact.2015 Sep 4;14:127. doi: 10.1186/s12934-015-0312-7.
- BACKGROUND: Ethylene glycol (EG) is a bulk chemical that is mainly used as an anti-freezing agent and a raw material in the synthesis of plastics. Production of commercial EG currently exclusively relies on chemical synthesis using fossil resources. Biochemical production of ethylene glycol from ren
- PMID 26336892
Japanese Journal
- Glycolaldehyde-Forming Route in Bacillus subtilis in Relation to Vitamin B_6 Biosynthesis
- Sakai Akihiro,Katayama Keisi,Katsuragi Tohoru [他],TANI YOSHIKI
- Journal of bioscience and bioengineering 91(2), 147-152, 2001-02-25
- … Glycolaldehyde (GA) was shown to be a precursor of vitamin B_6 (B_6), and to be formed from glycolate by glycolaldehyde dehydrogenase (GADH) in Escherichia coli. … In this study, we show the glycolaldehyde-forming route in B_6 biosynthesis in Bacillus subtilis. …
- NAID 110002683799
- Metabolism of 2-Ketoaldehydes in Bacteria : Oxidative Conversion of Methylglyoxal to Pyruvate by an Enzyme from Pseudomonas putida(Microbiology & Fermentation Industry)
- RHEE Hae-ik,WATANABE Kunihiko,MURATA Kousaku,KIMURA Akira
- Agricultural and Biological Chemistry 51(4), 1059-1066, 1987-04-23
- … The enzyme was active on 2-ketoaldehydes [glyoxal, methylglyoxal (Km=1.0 mM) and phenylglyoxal] and some aldehydes (formaldehyde, acetaldehyde, glycolaldehyde and propionaldehyde) in the presence of NAD (Km=0.1 mM). … The bacterial methylglyoxal-oxidizing enzyme appeared similar to goat liver 2-ketoaldehyde dehydrogenase in molecular weight and structure, but was different in its substrate affinity. …
- NAID 110006323379
- Metabolism of 2-Oxoaldehydes in Bacteria: Purification and Characterization of Methylglyoxal Reductase from Escherichia coli
- SAIKUSA Toshihiko,RHEE Hae-ik,WATANABE Kunihiko,MURATA Kousaku,KIMURA Akira
- Agricultural and Biological Chemistry 51(7), 1893-1899, 1987
- … The activities of 2-oxoaldehyde-metabolizing enzymes (glyoxalase I, glyoxalase II, methylglyoxal reductase, methylgjyoxal dehydrogenase and lactaldehyde dehydrogenase) were found to be widely distributed among microorganisms. … The enzyme utilized both NADPH and NADH for the reduction of 2-oxoaldehydes (glyoxal, methylglyoxal, phenylglyoxal and 4, 5-dioxovalerate) and some aldehydes (glycolaldehyde, D, L-glyceraldehyde, propionaldehyde and acetaldehyde). …
- NAID 130000024989
Related Links
- 1. J Biol Chem. 1983 Jun 25;258(12):7788-92. Identification of lactaldehyde dehydrogenase and glycolaldehyde dehydrogenase as functions of the same protein in Escherichia coli. Caballero E, Baldomá L, Ros J, Boronat A, Aguilar J. ...
- Aldehyde dehydrogenase A / Glycolaldehyde dehydrogenase Gene N/A Organism Klebsiella pneumoniae IS53 Status Unreviewed-Annotation score: Annotation score: 1 out of 5-Protein predicted i Function i GO - Molecular i i i ...
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