glycogen phosphorylase

出典: meddic

グリコーゲンホスホリラーゼ

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出典(authority):フリー百科事典『ウィキペディア(Wikipedia)』「2016/07/04 18:09:56」(JST)

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英文文献

  • 3'-Axial CH(2) OH Substitution on Glucopyranose does not Increase Glycogen Phosphorylase Inhibitory Potency. QM/MM-PBSA Calculations Suggest Why.
  • Manta S, Xipnitou A, Kiritsis C, Kantsadi AL, Hayes JM, Skamnaki VT, Lamprakis C, Kontou M, Zoumpoulakis P, Zographos SE, Leonidas DD, Komiotis D.SourceDepartment of Biochemistry and Biotechnology, University of Thessaly, 26 Ploutonos Str., 41221 Larissa, Greece Institute of Organic and Pharmaceutical Chemistry, National Hellenic Research Foundation, 48 Vassileos Constantinou Avenue, 11635 Athens, Greece.
  • Chemical biology & drug design.Chem Biol Drug Des.2012 May;79(5):663-73. doi: 10.1111/j.1747-0285.2012.01349.x. Epub 2012 Mar 7.
  • Glycogen phosphorylase is a molecular target for the design of potential hypoglycemic agents. Structure-based design pinpointed that the 3'-position of glucopyranose equipped with a suitable group has the potential to form interactions with enzyme's cofactor, pyridoxal 5'-phosphate (PLP), thus enhan
  • PMID 22296957
  • A new eudesmane sesquiterpene glycosides from Liriope muscari.
  • Jiang C, Liu ZH, Li L, Lin BB, Yang F, Qin MJ.Sourcea Department of Resources Science of Traditional Chinese Medicines , China Pharmaceutical University , Nanjing , 210009 , China.
  • Journal of Asian natural products research.J Asian Nat Prod Res.2012 May;14(5):491-5. Epub 2012 Mar 16.
  • A new eudesmane sesquiterpene glycoside, ophiopogonoside B (1), along with five known compounds, ophiopogonoside A (2), ruscogenin-1-O-[β-d-glucopyranosyl (1 → 2)]-[β-d-xylopyranosyl (1 → 3)]-β-d-fucopyranoside (3), palmitic acid (4), palmitic acid glyceride (5), and β-sitosterol-d-gluco
  • PMID 22423627

和文文献

  • Properties and functions of the storage sites of glycogen phosphorylase
  • Makino Yasushi,Fujii Yuta,Taniguchi Motoi
  • The journal of biochemistry 157(6), 451-458, 2015-06
  • NAID 40020489240
  • Uterine glycogen metabolism in mink during estrus, embryonic diapause and pregnancy
  • DEAN Matthew,HUNT Jason,MCDOUGALL Lisa [他],ROSE Jack
  • Journal of Reproduction and Development 60(6), 438-446, 2014
  • … We have determined uterine glycogen content, metabolizing enzyme expression and activity in the mink, a species that exhibits obligatory embryonic diapause, resulting in delayed implantation. … Gross uterine glycogen concentrations were highest in estrus, decreased 50% by diapause and 90% in pregnancy (P ≤ 0.05). …
  • NAID 130004774175
  • Uterine Glycogen Metabolism in Mink during Estrus, Embryonic Diapause and Pregnancy
  • DEAN Matthew,HUNT Jason,MCDOUGALL Lisa,ROSE Jack
  • Journal of Reproduction and Development, 2014
  • … We have determined uterine glycogen content, metabolizing enzyme expression and activity in the mink, a species that exhibits obligatory embryonic diapause, resulting in delayed implantation. … Gross uterine glycogen concentrations were highest in estrus, decreased 50% by diapause and 90% in pregnancy (P≤0.05). … Endometrial glycogen deposits, which localized primarily to glandular and luminal epithelia, decreased 99% between estrus and diapause (P≤0.05) and were nearly undetectable in pregnancy. …
  • NAID 130004687240

関連リンク

Glycogen phosphorylase can act only on linear chains of glycogen (α1-4 glycosidic linkage). Its work will immediately come to a halt four residues away from α1-6 branch (which are exceedingly common in glycogen). In these ...
Glycogen (n residues) + P i à glycogen (n-1 residues) + glucose-1-phosphate This phosphorolysis reaction may be compared to cleavage by water during hydrolysis: ... Pyridoxal phosphate (PLP), a derivative of vitamin B 6, serves as prosthetic group for Glycogen Phosphorylase.

関連画像

 of Glycogen Phosphorylase on Glycogen of glycogen phosphorylase in liverGlycogen phosphorylase and its Mechanism the regulation of glycogen phosphorylase Regulation of glycogen phosphorylaseGlycogen phosphorylase [ edit ]


★リンクテーブル★
リンク元グリコーゲンホスホリラーゼ」「グルコース1-リン酸」「ホスホリラーゼ
拡張検索muscle form glycogen phosphorylase」「liver form glycogen phosphorylase」「brain form glycogen phosphorylase
関連記事glycogen

グリコーゲンホスホリラーゼ」

  [★]

phosphoryl
glycogen phosphorylase
グリコーゲン
  • first aid step1 2006 p.98

調節

  • 細胞内cAMP濃度 (HBC.160)
インスリン → ↓cAMP → ↓glycogen phosphorylase
グルカゴンエピネフリン → ↑cAMP → ↑glycogen phosphorylase
  • cAMP非依存的経路 (HBC.162)
  • Ca2+
  • Ca2+やphosphatidylinositol bisphosphate pathway
  • バソプレシン、オキシトシン、アンジオテンシンII

臨床関連

  • 骨格筋のグリコーゲンホスホリラーゼ欠損

USMLE

  • Q book p.139 33



グルコース1-リン酸」

  [★]

glucose 1-phosphate glucose-1-phosphate G1P, glucose 1-phosphoric acid glucose-1-phosphoric acid
グルコース1リン酸グルコース-1-リン酸
グリコーゲングルコース6-リン酸

代謝

グリコーゲン合成

グリコーゲン分解

グルコース合成系と解糖系とをつなぐ反応


ホスホリラーゼ」

  [★]

phosphorylase, PR
リン酸付加分解酵素グリコーゲンホスホリラーゼ glycogen phosphorylaseアミロホスホリラーゼ amylophosphorylase



muscle form glycogen phosphorylase」

  [★]

myophosphorylase


liver form glycogen phosphorylase」

  [★]


brain form glycogen phosphorylase」

  [★]


glycogen」

  [★] グリコーゲン

WordNet   license wordnet

「one form in which body fuel is stored; stored primarily in the liver and broken down into glucose when needed by the body」
animal starch

PrepTutorEJDIC   license prepejdic

「グリコーゲン,糖原」




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