glutathione S-transferases

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  • Differential metabolism of 4-hydroxynonenal in liver, lung and brain of mice and rats.
  • Zheng R1, Dragomir AC1, Mishin V1, Richardson JR2, Heck DE3, Laskin DL1, Laskin JD4.
  • Toxicology and applied pharmacology.Toxicol Appl Pharmacol.2014 Aug 15;279(1):43-52. doi: 10.1016/j.taap.2014.04.026. Epub 2014 May 14.
  • The lipid peroxidation end-product 4-hydroxynonenal (4-HNE) is generated in tissues during oxidative stress. As a reactive aldehyde, it forms Michael adducts with nucleophiles, a process that disrupts cellular functioning. Liver, lung and brain are highly sensitive to xenobiotic-induced oxidative st
  • PMID 24832492
  • A cytosolic glutathione s-transferase, GST-theta from freshwater prawn Macrobrachium rosenbergii: molecular and biochemical properties.
  • Arockiaraj J1, Gnanam AJ2, Palanisamy R3, Bhatt P3, Kumaresan V3, Chaurasia MK3, Pasupuleti M4, Ramaswamy H5, Arasu A6, Sathyamoorthi A7.
  • Gene.Gene.2014 Aug 10;546(2):437-42. doi: 10.1016/j.gene.2014.05.063. Epub 2014 May 28.
  • Glutathione S-transferases play an important role in cellular detoxification and may have evolved to protect cells against reactive oxygen metabolites. In this study, we report the molecular characterization of glutathione s-transferase-theta (GST-θ) from freshwater prawn Macrobrachium rosenbergii.
  • PMID 24879918
  • GSTT1 and GSTM1 polymorphisms predict treatment outcome for acute myeloid leukemia: a systematic review and meta-analysis.
  • Xiao Q1, Deng D, Li H, Ye F, Huang L, Zhang B, Ye B, Mo Z, Yang X, Liu Z.
  • Annals of hematology.Ann Hematol.2014 Aug;93(8):1381-90. doi: 10.1007/s00277-014-2050-z. Epub 2014 Mar 29.
  • Glutathione S-transferases (GSTs) contribute to the metabolism of different xenobiotics and anticancer drugs and confer protection against oxidative stress thus may influence the treatment outcome of acute myeloid leukemia (AML). Studies regarding the association between GSTT1 and GSTM1 polymorphism
  • PMID 24994605


  • ビタミンCとグルタチオンS-トランスフェラーゼの遺伝子多型(<特集>「ビタミンと遺伝子多型」-ビタミンC-)
  • 太田 好次
  • ビタミン 87(9), 501-505, 2013-09-25
  • … There are many gene polymorphisms for glutathione S-transferases (GSTs). …
  • NAID 110009636190
  • グルタチオンS-転移酵素の構造と機能─薬剤による抵抗性発現からの脱却─
  • 宮本 徹
  • 東京農業大学農学集報 57(4), 247-260, 2013-03-18
  • … グルタチオンS-転移酵素(GST)はミクロソーム酸化酵素であるチトクローム P450 と並んで生物体に広く存在する抱合酵素である。 …
  • NAID 110009558070
  • Thioacetamide-induced Hepatocellular Necrosis Is Attenuated in Diet-induced Obese Mice
  • Shirai Makoto,Arakawa Shingo,Miida Hiroaki [他],MATSUYAMA Takuya,KINOSHITA Junzo,MAKINO Toshihiko,KAI Kiyonori,TERANISHI Munehiro
  • Journal of Toxicologic Pathology 26(2), 175-186, 2013
  • … To clarify the mechanisms by which the hepatic necrosis was attenuated, we investigated exposure to thioacetamide and one of its metabolites, the expression of CYP2E1, which converts thioacetamide to reactive metabolites, and the content of glutathione S-transferases in the liver. … On the other hand, at 8 hours after thioacetamide administration, hepatic total glutathione in mice fed the high-fat diet was significantly lower than that in mice fed the normal diet. …
  • NAID 130003362372


Glutathione S-transferases (GSTs), previously known as ligandins, comprise a family of eukaryotic and prokaryotic phase II metabolic isozymes best known for their ability to catalyze the conjugation of the reduced form of glutathione (GSH) to ...
1. Curr Med Chem. 1999 Apr;6(4):279-309. Glutathione S-transferases--a review. Salinas AE(1), Wong MG. Author information: (1)Chemistry Department, Swinburne University of Technology, John St., Hawthorn, 3122 ...






  • n.

WordNet   license wordnet

「any of various enzymes that move a chemical group from one compound to another compound」



WordNet   license wordnet

「the 19th letter of the Roman alphabet」

PrepTutorEJDIC   license prepejdic

「sulfurの化学記号 / {略}South[ern]」


  [★] トランスフェラーゼ


  [★] グルタチオン GSH