グルタミン酸tRNAリガーゼ
- 関
- glutamyl-tRNA synthetase
WordNet
- a salt or ester of glutamic acid
Wikipedia preview
出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2013/07/10 09:30:22」(JST)
[Wiki en表示]
| glutamate-tRNA ligase |
| Identifiers |
| EC number |
6.1.1.17 |
| CAS number |
9068-76-2 |
| Databases |
| IntEnz |
IntEnz view |
| BRENDA |
BRENDA entry |
| ExPASy |
NiceZyme view |
| KEGG |
KEGG entry |
| MetaCyc |
metabolic pathway |
| PRIAM |
profile |
| PDB structures |
RCSB PDB PDBe PDBsum |
| Gene Ontology |
AmiGO / EGO |
| Search |
| PMC |
articles |
| PubMed |
articles |
| NCBI |
proteins |
|
In enzymology, a glutamate-tRNA ligase (EC 6.1.1.17) is an enzyme that catalyzes the chemical reaction
- ATP + L-glutamate + tRNAGlu AMP + diphosphate + L-glutamyl-tRNAGlu
The 3 substrates of this enzyme are ATP, L-glutamate, and tRNA(Glu), whereas its 3 products are AMP, diphosphate, and L-glutamyl-tRNA(Glu).
This enzyme belongs to the family of ligases, to be specific those forming carbon-oxygen bonds in aminoacyl-tRNA and related compounds. The systematic name of this enzyme class is L-glutamate:tRNAGlu ligase (AMP-forming). Other names in common use include glutamyl-tRNA synthetase, glutamyl-transfer ribonucleate synthetase, glutamyl-transfer RNA synthetase, glutamyl-transfer ribonucleic acid synthetase, glutamate-tRNA synthetase, and glutamic acid translase. This enzyme participates in 3 metabolic pathways: glutamate metabolism, porphyrin and chlorophyll metabolism, and aminoacyl-trna biosynthesis.
Structural studies[edit]
As of late 2007, 16 structures have been solved for this class of enzymes, with PDB accession codes 1FYJ, 1G59, 1J09, 1N75, 1N77, 1N78, 2CFO, 2CUZ, 2CV0, 2CV1, 2CV2, 2DXI, 2HRA, 2HRK, 2HSM, and 2O5R.
References[edit]
- Ravel JM, Wang S, Heinemeyer C and Shive W (1965). "Glutamyl and glutaminyl ribonucleic acid synthetases of Escherichia coli W. Separation, properties, and stimulation of adenosine triphosphate-pyrophosphate exchange by acceptor ribonucleic acid". J. Biol. Chem. 240: 432–438. PMID 14253448.
|
Enzymes: CO CS and CN ligases (EC 6.1-6.3)
|
|
| 6.1: Carbon-Oxygen |
- Aminoacyl tRNA synthetase
- Tyrosine
- Tryptophan
- Threonine
- Leucine
- Isoleucine
- Lysine
- Alanine
- Valine
- Methionine
- Serine
- Aspartate
- D-alanine-poly(phosphoribitol) ligase
- Glycine
- Proline
- Cysteine
- Glutamate
- Glutamine
- Arginine
- Phenylalanine
- Histidine
- Asparagine
- Aspartate
- Glutamate
- Lysine
|
|
| 6.2: Carbon-Sulfur |
- Succinyl coenzyme A synthetase - Acetyl Co-A synthetase - Long fatty acyl CoA synthetase
|
|
| 6.3: Carbon-Nitrogen |
- Glutamine synthetase
- Ubiquitin ligase
- Cullin
- Von Hippel-Lindau tumor suppressor
- UBE3A
- Mdm2
- Anaphase-promoting complex
- UBR1
- Glutathione synthetase
- CTP synthase
- Adenylosuccinate synthase
- Argininosuccinate synthetase
- Holocarboxylase synthetase
- GMP synthase
- Asparagine synthetase
- Carbamoyl phosphate synthetase
- Gamma-glutamylcysteine synthetase
|
|
- B
- enzm
- 1.1
- 2
- 3
- 4
- 5
- 6
- 7
- 8
- 10
- 11
- 13
- 14
- 15-18
- 2.1
- 3.1
- 4.1
- 5.1
- 6.1-3
|
|
|
|
|
Ligases: carbon-carbon ligases (EC 6.4)
|
|
| Biotin dependent carboxylase |
- Pyruvate carboxylase
- Acetyl-CoA carboxylase
- Propionyl-CoA carboxylase
- Methylcrotonyl-CoA carboxylase
|
|
| Other |
|
|
- B
- enzm
- 1.1
- 2
- 3
- 4
- 5
- 6
- 7
- 8
- 10
- 11
- 13
- 14
- 15-18
- 2.1
- 3.1
- 4.1
- 5.1
- 6.1-3
|
|
|
|
|
Enzymes: Phosphoric ester and nitrogen-metal ligases (EC 6.5-6.6)
|
|
| 6.5: Phosphoric Ester |
|
|
| 6.6: Nitrogen-Metal |
- Magnesium chelatase
- Cobaltochelatase
|
|
- B
- enzm
- 1.1
- 2
- 3
- 4
- 5
- 6
- 7
- 8
- 10
- 11
- 13
- 14
- 15-18
- 2.1
- 3.1
- 4.1
- 5.1
- 6.1-3
|
|
|
|
UpToDate Contents
全文を閲覧するには購読必要です。 To read the full text you will need to subscribe.
English Journal
- The kinases HipA and HipA7 phosphorylate different substrate pools in Escherichia coli to promote multidrug tolerance.
- Semanjski M1, Germain E2, Bratl K1, Kiessling A1, Gerdes K3, Macek B4.
- Science signaling.Sci Signal.2018 Sep 11;11(547). pii: eaat5750. doi: 10.1126/scisignal.aat5750.
- PMID 30206139
- Specific protein carbonylation in human breast cancer tissue compared to adjacent healthy epithelial tissue.
- Aryal B1, Rao VA1.
- PloS one.PLoS One.2018 Mar 29;13(3):e0194164. doi: 10.1371/journal.pone.0194164. eCollection 2018.
- PMID 29596499
- A water-mediated and substrate-assisted aminoacylation mechanism in the discriminating aminoacyl-tRNA synthetase GlnRS and non-discriminating GluRS.
- Aboelnga MM1, Hayward JJ, Gauld JW.
- Physical chemistry chemical physics : PCCP.Phys Chem Chem Phys.2017 Sep 27;19(37):25598-25609. doi: 10.1039/c7cp02969a.
- PMID 28905057
Related Links
- In enzymology, a glutamate-tRNA ligase (EC 6.1.1.17) is an enzyme that catalyzes the chemical reaction ATP + L-glutamate + tRNAGlu AMP + diphosphate + L-glutamyl-tRNAGlu The 3 substrates of this enzyme are ATP, L ...
- In enzymology, a glutamate-tRNAGln ligase (EC 6.1.1.24) is an enzyme that catalyzes the chemical reaction ATP + L-glutamate + tRNAGlx AMP + diphosphate + glutamyl ... ID, GO:0050561. Name, glutamate-tRNA(Gln) ligase ...
Related Pictures
★リンクテーブル★
[★]
グルタミルtRNA合成酵素、グルタミルtRNAシンテターゼ
- 関
- glutamate-tRNA ligase
[★]
- 英
- glutamate-tRNA ligase
- 関
- グルタミルtRNA合成酵素
[★]
グルタミン酸、グルタメート、グルタメイト、(化合物)グルタミン酸塩
[★]
トランスファーRNA, transfer RNA, 転位RNA
[★]
リガーゼ、連結酵素
- 関
- synthetase
[★]
トランスファーRNA transfer RNAs
[★]
tRNAリガーゼ
- 関
- RNA ligase