WordNet

the property of something that can be pervaded by a liquid (as by osmosis or diffusion) (同)permeableness
a constant number that serves as a measure of some property or characteristic
of or relating to glomeruli

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浸透性
(数学で)係数,(物理で)係数,率

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1. 糸球体の免疫障害の機序 mechanisms of immune injury of the glomerulus
2. 成人における微小変化群の病因、臨床的特徴、および診断 etiology clinical features and diagnosis of minimal change disease in adults
3. 血液透析装置の概要 overview of the hemodialysis apparatus
4. 持続的腎代替療法中の薬物除去 drug removal during continuous renal replacement therapy
5. 前立腺癌におけるMRIの役割 the role of magnetic resonance imaging in prostate cancer

English Journal

Extracellular fetal hemoglobin (HbF) induces increases in glomerular permeability. Inhibition with α1-microglobulin (A1M) and Tempol.

Sverrisson K, Axelsson J, Rippe A, Gram M, Akerström B, Hansson SR, Rippe B.Author information 1Lund University.AbstractBackground: Extracellular fetal hemoglobin (HbF) and adult hemoglobin (HbA) are pro-inflammatory and generate reactive oxygen species (ROS). Increased plasma levels of extracellular HbF have recently been reported to occur in early preeclampsia (PE). A1M is a physiological heme binding protein and radical scavenger that has been shown to counteract vascular permeability increases induced by HbA in perfused placenta. The present study was performed to investigate whether HbF and HbA will increase glomerular permeability in vivo and to test whether A1M and Tempol, a ROS scavenger, can prevent their effects. Methods: Anaesthetized Wistar rats were continuously infused i.v. with either HbA, HbF or cyano(CN)-HbF, together with fluorescein isothiocyanate (FITC)-Ficoll-70/400, Inulin and 51Cr-EDTA for 2h. Plasma samples and urine samples (left ureter) were taken repeatedly and analyzed by high performance size exclusion chromatography (HPSEC) for assessing glomerular sieving coefficients (θ) for Ficoll of radius 10-80Å. In separate experiments A1M or Tempol was given before and during the Hb infusions. Results: Extracellular HbF caused rapid, transient increases in glomerular permeability to large Ficoll molecules (50-80Å), contrary to the effects of HbA and CN-HbF. For HbF θ-Ficoll60Å thus increased from 3.85 ± 0.85 x 10-5 to 2.60 ± 0.96 x 10-4 at 15 min, changes which were abrogated by Tempol and reduced by A1M. Conclusions: Our data demonstrate that extracellular HbF, infused systemically, can acutely increase glomerular permeability through inducing oxidative stress.
American journal of physiology. Renal physiology.Am J Physiol Renal Physiol.2013 Dec 11. [Epub ahead of print]
Background: Extracellular fetal hemoglobin (HbF) and adult hemoglobin (HbA) are pro-inflammatory and generate reactive oxygen species (ROS). Increased plasma levels of extracellular HbF have recently been reported to occur in early preeclampsia (PE). A1M is a physiological heme binding protein and r
PMID 24338823

Scavengers of reactive oxygen species, paracalcitol, RhoA, and Rac-1 inhibitors and tacrolimus inhibit angiotensin II-induced actions on glomerular permeability.

Axelsson J, Rippe A, Sverrisson K, Rippe B.Author information Department of Nephrology, Lund University, Lund, Sweden.AbstractSystemic infusions of ANG II rapidly induce large, dynamic increases in the permeability of the glomerular filtration barrier (GFB) in rats. After binding to its receptor(s), ANG II generates reactive oxygen species (ROS) and produces Ca²⁺ influx into cells, leading to activation of a plethora of signaling cascades, including, e.g., calcineurin and small GTPases, such as Rac-1 and RhoA. In the present study we sought to interact with some of these cascades to test potential novel antiproteinuric agents. In anesthetized Wistar rats, the left urether was cannulated for urine collection, and blood access was achieved. Rats were infused with ANG II (16 ng·kg⁻¹·min⁻¹) alone, or together with the ROS scavengers tempol or dimethylthiourea (DMTU) or the D-vitamin analog paracalcitol, the RhoA-kinase inhibitor Y-27632, the Rac-1 inhibitor NSC-23766, or the calcineurin inhibitor tacrolimus. FITC-Ficoll-70/400 (mol.radius 10-80 Å) and ⁵¹Cr-EDTA were infused throughout the experiment. Plasma and urine samples were taken during baseline and at 5 and 15 min after the start of the infusions and analyzed by high-performance size-exclusion chromatography for determination of glomerular sieving coefficients (θ) for Ficoll10-80Å. ANG II infusion into rats caused marked increases in glomerular permeability to large Ficoll molecules (Ficoll50-80Å), which were abrogated by the ROS scavenger tempol and partly by DMTU. Paracalcitol, RhoA, and Rac-1 inhibition, and, to some extent tacrolimus, but not prostacyclin, could also inhibit the glomerular permeability actions of ANG II. Our data suggest that cellular ROS generation and active Ca²⁺ signaling are involved in ANG II-induced increases in glomerular permeability.
American journal of physiology. Renal physiology.Am J Physiol Renal Physiol.2013 Aug 1;305(3):F237-43. doi: 10.1152/ajprenal.00154.2013. Epub 2013 May 8.
Systemic infusions of ANG II rapidly induce large, dynamic increases in the permeability of the glomerular filtration barrier (GFB) in rats. After binding to its receptor(s), ANG II generates reactive oxygen species (ROS) and produces Ca²⁺ influx into cells, leading to activation of a plethora of
PMID 23657856

Clinical values of urinary IL-6 in asymptomatic renal hematuria and renal hematuria with proteins.

Song M, Ma L, Yang D, He Z, Li C, Pan T, Li A.Author information Integrated Chinese and Western Medicine Treatment of Renal Disease Centre, Beidaihe Sanatorium of Beijing Military Area Command, Qinhuangdao, Hebei 066100, P.R. China.AbstractRenal hematuria is caused by glomerular disease. Under pathological conditions, the distribution of interleukin-6 (IL-6) in kidney tissue is abnormal and urinary IL-6 levels are increased. Abnormal IL-6 secretion promotes the hyperplasia of mesangial cells and matrix and, thus, affects the permeability of the glomerular filtration membrane. Therefore, the detection of urinary IL-6 levels in patients with renal hematuria is beneficial for disease evaluation. A total of 82 patients with primary renal hematuria were divided into group 1 (UPr/24 h < 150 mg; pure hematuria group), group 2 (150 mg ≤ UPr/24 h ≤ 1,000 mg) and group 3 (UPr/24 h > 1,000 mg). A total of 30 normal individuals were selected as the controls. The urinary IL-6 levels were detected by the enzyme-linked immunosorbent assay (ELISA) method and a renal biopsy was conducted. The urinary IL-6 levels and renal pathological damage scores in groups 1 and 2 were significantly reduced compared with those in group 3, (P<0.001 and 0.01, respectively), with no significant difference between groups 1 and 2 (P>0.05). The correlation coefficient (r) of urinary IL-6 with 24 h urinary protein (UPr/24 h) in groups 1, 2 and 3 was 0.017, 0.045 and 0.747, respectively, and that of urinary IL-6 with renal pathological damage score was 0.627, 0.199 and 0.119, respectively. The UPr/24 h was significantly correlated with IL-6 level (r=0.7320, P<0.000). In group 1, the urinary IL-6 levels were correlated with the degree of renal pathological damage. A positive correlation was observed between urinary IL-6 levels and UPr/24 h.
Experimental and therapeutic medicine.Exp Ther Med.2013 Aug;6(2):396-400. Epub 2013 May 20.
Renal hematuria is caused by glomerular disease. Under pathological conditions, the distribution of interleukin-6 (IL-6) in kidney tissue is abnormal and urinary IL-6 levels are increased. Abnormal IL-6 secretion promotes the hyperplasia of mesangial cells and matrix and, thus, affects the permeabil
PMID 24137196

Japanese Journal

腎性機序に基づいた高血圧の新しい分類

木村玄次郎
日本腎臓学会誌 36(10), 1075-1081, 1994
… On the other hand, the slope of the pressure-natriuresis relationship is determined by glomerulo-tubular balance of sodium, which is mainly controlled by the difference between the whole kidney ultrafiltration coefficient and the rate of tubule sodium reabsorption. …
NAID 130004170095

運動性蛋白尿出現機序　激運動後の尿蛋白と尿中乳酸排せつとの関連:―激運動後の尿蛋白と尿中乳酸排泄との関連―

鈴木政登,井川幸雄
日本腎臓学会誌 33(4), 357-364, 1991
… Exercise-induced proteinuria is of the mixed glomerular-tubular type and has been thought to be due to increased glomerular permeability to macromolecular proteins in response to activation of the renin-angiotensin system and catecholamines and a reduction in renal hemodynamics, The excretion of the tubular type of proteins, however, can't be explained by the above mechanism. …
NAID 130004169811

URINE FLOW-DEPENDENCE AND INTERSPECIES VARIATION OF THE RENAL REABSORPTION OF SULFANILAMIDE

KOMIYA IZUMI
Journal of pharmacobio-dynamics 10(1), 1-7, 1987-01
… Furthermore, the reabsorption percent increased with the decrease of the glomerular filtration rate (GFR), even though the urine flow rate normalized by GFR was the same. …
NAID 110003636666