glomerular filtration rate

出典: meddic

糸球体濾過量 GFR

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出典(authority):フリー百科事典『ウィキペディア(Wikipedia)』「2015/05/13 21:40:17」(JST)

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英文文献

  • Smad7 inhibits AngII-mediated hypertensive nephropathy in a mouse model of hypertension.
  • Liu GX1, Li YQ1, Huang XR, Wei LH2, Zhang Y2, Feng M2, Meng XM2, Chen HY2, Shi YJ1, Lan HY.Author information 1*Department of Nephrology, Central Municipal Hospital of Huizhou, Huizhou, Guangdong, China.2‡Department of Medicine & Therapeutics, Li Ka Shing Institute of Health Sciences, The Chinese University of Hong Kong, Hong Kong SAR, China.AbstractThe TGFβ (transforming growth factor β)/SMAD and NF-κB (nuclear factor κB) signalling pathways play a key role in hypertensive nephropathy. The present study examined whether targeting these pathways by SMAD7, a downstream inhibitor of both pathways, blocks AngII (angiotensin II)-induced hypertensive kidney disease in mice. A doxycycline-inducible SMAD7-expressing plasmid was delivered into the kidney by a non-invasive ultrasound-microbubble technique before and after AngII infusion. Results showed that pre-treatment with SMAD7 prevented AngII-induced progressive renal injury by inhibiting an increase in proteinuria and serum creatinine while improving the glomerular filtration rate. Similarly, treatment with SMAD7 in the established hypertensive nephropathy at day 14 after AngII infusion halted the progressive renal injury. These preventive and therapeutic effects of SMAD7 on hypertensive kidney injury were associated with inhibition of AngII-induced up-regulation of SMURF2 (SMAD-specific E3 ubiquitin protein ligase 2) and Sp1 (specificity protein 1), blockade of TGFβ/Smad3-mediated renal fibrosis and suppression of NF-κB-driven renal inflammation. Moreover, overexpression of SMAD7 also prevented AngII-induced loss of renal miR-29b, an miRNA with an inhibitory role in both TGFβ/Smad3 and NF-κB pathways. In conclusion, SMAD7 may be a therapeutic agent for AngII-mediated hypertensive nephropathy. Inhibition of the Sp1/SMAD3/NF-κB/miR-29b regulatory network may be a mechanism by which SMAD7 inhibits hypertensive nephropathy.
  • Clinical science (London, England : 1979).Clin Sci (Lond).2014 Aug 1;127(3):195-208. doi: 10.1042/CS20130706.
  • The TGFβ (transforming growth factor β)/SMAD and NF-κB (nuclear factor κB) signalling pathways play a key role in hypertensive nephropathy. The present study examined whether targeting these pathways by SMAD7, a downstream inhibitor of both pathways, blocks AngII (angiotensin II)-induced hyperte
  • PMID 24511990
  • Glomerular Filtration Rate Equations Do Not Accurately Predict Vancomycin Trough Concentrations in Pediatric Patients.
  • Alford EL1, Chhim RF, Crill CM, Hastings MC, Ault BH, Shelton CM.Author information 1Le Bonheur Children's Hospital, Memphis, TN, USA.AbstractBACKGROUND: The Bedside Chronic Kidney Disease in Children (CKiD) equation was developed using data from children with chronic kidney disease. Some institutions are using this equation in all pediatric patients, regardless of renal function, to adjust medications. No data have shown that the Bedside CKiD equation is equivalent or better than the Schwartz equation in estimating glomerular filtration rate (GFR) in pediatric patients with normal renal function.
  • The Annals of pharmacotherapy.Ann Pharmacother.2014 Jun;48(6):691-696. Epub 2014 Mar 19.
  • BACKGROUND: The Bedside Chronic Kidney Disease in Children (CKiD) equation was developed using data from children with chronic kidney disease. Some institutions are using this equation in all pediatric patients, regardless of renal function, to adjust medications. No data have shown that the Bedside
  • PMID 24646680
  • Serum levels of fibroblast growth factor-21 are increased in chronic and acute renal dysfunction.
  • Hindricks J1, Ebert T, Bachmann A, Kralisch S, Lössner U, Kratzsch J, Stolzenburg JU, Dietel A, Beige J, Anders M, Bast I, Blüher M, Stumvoll M, Fasshauer M.Author information 1Department of Endocrinology and Nephrology, University of Leipzig, Leipzig, Germany; IFB Adiposity Diseases, Leipzig University Medical Center, Leipzig, Germany.AbstractOBJECTIVE: Fibroblast growth factor (FGF)-21 has recently been introduced as a circulating adipokine which reverses insulin resistance and obesity in rodents. In this study, regulation of FGF-21 in renal dysfunction was elucidated in both chronic kidney disease (CKD) and acute kidney dysfunction (AKD).
  • Clinical endocrinology.Clin Endocrinol (Oxf).2014 Jun;80(6):918-24. doi: 10.1111/cen.12380. Epub 2014 Jan 12.
  • OBJECTIVE: Fibroblast growth factor (FGF)-21 has recently been introduced as a circulating adipokine which reverses insulin resistance and obesity in rodents. In this study, regulation of FGF-21 in renal dysfunction was elucidated in both chronic kidney disease (CKD) and acute kidney dysfunction (AK
  • PMID 24612017

和文文献

  • Sex differences in serum ck activity but not in glomerular filtration rate after resistance exercise : is there a sex dependent renal adaptative response?
  • Amorim Mayra Z.,Machado Marco,Hackney Anthony C. [他]
  • The journal of physiological sciences 64(1), 31-36, 2014-01
  • NAID 40019938019
  • Japan Diabetic Nephropathy Cohort Study: Study design, methods, and implementation
  • Furuichi Kengo,Shimizu Miho,Toyama Tadashi,Koya Daisuke,Koshino Yoshitaka,Abe Hideharu,Mori Kiyoshi,Satoh Hiroaki,Imanishi Masahito,Iwano Masayuki,Yamauchi Hiroyuki,Kusano Eiji,Fujimoto Shouichi,Suzuki Yoshiki,Okuda Seiya,Kitagawa Kiyoki,Iwata Yasunori,Kaneko Shuichi,Nishi Shinichi,Yokoyama Hitoshi,Ueda Yoshihiko,Haneda Masakazu,Makino Hirofumi,Wada Takashi
  • Clinical and Experimental Nephrology 17(6), 819-826, 2013-12
  • … Median estimated glomerular filtration rate (eGFR) was 33.3 ml/min/1.73 m2. …
  • NAID 120005368210
  • Association of arteriosclerosis with early chronic obstructive pulmonary disease without respiratory symptoms
  • 野池 博文,杉山 佑公,飯塚 卓夫,清水 一寛,高橋 真生,鈴木 理代,平野 圭一,美甘 周史,中神 隆洋,清川 甫,佐藤 修司,黒須 巧,川島 辰男
  • 東邦医学会雑誌 60(5), 258-266, 2013-09
  • … To evaluate associations with COPD stage, we evaluated arteriosclerosis markers, including estimated glomerular filtration rate (eGFR), carotid artery plaque score (PS), cardio-ankle vascular index (CAVI), and high-sensitivity C-reactive protein (hs-CRP), an inflammatory marker also known as an arteriosclerosis-promoting factor. …
  • NAID 120005346166

関連リンク

postneonatal mortality rate the ratio of the number of deaths in a given year of children between the 28th day of life and the first birthday relative to the difference between the number of the live births and neonatal deaths in that year ...
Glomerular-Filtration-Rate.com - Articles on gfr, kidney function and kidney failure. A library of scientific articles on glomerular filtration rate, cardiovascular deseases and kidney failure. Welcome to Glomerular-Filtration-Rate.com. This ...
Glomerular filtration rate (GFR) is a test used to check how well the kidneys are working. Specifically, it estimates how much blood passes through the glomeruli each minute. Glomeruli are the tiny filters in the kidneys ...

関連画像

of estimated glomerular filtration rate Factors affecting filtrationGlomerular filtration rate. Causes  Clearance and Glomerular Filtration RateGlomerular filtration rate (GFR) is a test The glomerular filtration rate is the


★リンクテーブル★
リンク元糸球体濾過量」「GFR
拡張検索estimated glomerular filtration rate
関連記事rate」「rat」「filtration」「rating」「glomerular

糸球体濾過量」

  [★]

glomerular filtration rate, GFR
糸球体濾過率 「糸球体濾過量」の方がよく使われているらしい
糸球体濾過値イヌリンクリアランスクレアチニンクリアランス慢性腎不全推算糸球体濾過量 eGFR


概念

  • 糸球体で濾過される血漿の量(厳密には時間あたりの量)
  • 糸球体で完全に排泄される物質を使って算出する
  • 成人のGFR:100-150 ml/min (SP.778)

試験

GFRに影響を与える因子

  • 上昇:妊娠、糖尿病性早期腎症、蛋白の過剰摂取(尿中のクレアチニンの影響を受ける(出典不明))、アンジオテンシンII
  • 低下:脱水
考える技術 第2版 p.528
輸入細動脈抵抗低下不能 輸出細動脈抵抗上昇負荷 腎血管閉塞
高血圧
動脈硬化
慢性高血圧
慢性腎臓病
悪性高血圧
NSAID
COX-2阻害薬
敗血症
高カルシウム血症
シクロスポリン
タクロリムス
腎動脈狭窄
ACE阻害薬
ARB
腎動脈狭窄

理論値

  • (1) Ccrからの近似する方法
  • Ccr=((140-年齢)×体重(kg))/(72×Cr(mg/dL))(女性では×0.85)
  1. ref(GFR_fig.png,[糸球体濾過量])


GFR」

  [★] 糸球体濾過量 glomerular filtration rate

estimated glomerular filtration rate」

  [★] eGFR推算糸球体濾過量


rate」

  [★]

  • n.
  • (全体に対する部分などの割合を示す)率   ⇔ (率を率で除すような比 ratioとは区別するでしょう)
  • vi.
  • 格付けされる、等級に分けられる
  • 影響力がある、重要な地位にある
  • vt.
  • ~を値踏みする、~の価格を査定する
  • (~の重要性や価値を)評価する
  • (性能などによって)~を格付けする(等級に分ける)
  • (金融)(不動産の)課税額を決める
  • ~に値する、~の価値がある

WordNet   license wordnet

「be worthy of or have a certain rating; "This bond rates highly"」

WordNet   license wordnet

「amount of a charge or payment relative to some basis; "a 10-minute phone call at that rate would cost $5"」
charge per unit

WordNet   license wordnet

「a magnitude or frequency relative to a time unit; "they traveled at a rate of 55 miles per hour"; "the rate of change was faster than expected"」

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「a quantity or amount or measure considered as a proportion of another quantity or amount or measure; "the literacy rate"; "the retention rate"; "the dropout rate"」

WordNet   license wordnet

「assign a rank or rating to; "how would you rank these students?"; "The restaurant is rated highly in the food guide"」
rank, range, order, grade, place

WordNet   license wordnet

「estimate the value of; "How would you rate his chances to become President?"; "Gold was rated highly among the Romans"」
value

PrepTutorEJDIC   license prepejdic

「〈C〉『割合』,『率』 / 〈C〉《the~,a~》『速度』(speed),進度 / 〈C〉『値段』,『相場』;料金 / 〈U〉等級(class),(…)等 / 《複数形ぃ》《英》地方税 / (…の金額に)…‘の'『値段を決める』,見積もる《+『名』+『at』+『名』》 / …‘を'『評価する』,みなす / 《米話》…‘に'値する,‘の'価値がある / 『評価される』;みなされる」

PrepTutorEJDIC   license prepejdic

「…‘を'どなりつける」


rat」

  [★]

  • n.
laboratory ratmouseNorway ratRattusRattus norvegicus

WordNet   license wordnet

「give (hair) the appearance of being fuller by using a rat」

WordNet   license wordnet

「a pad (usually made of hair) worn as part of a woman''s coiffure」

WordNet   license wordnet

「any of various long-tailed rodents similar to but larger than a mouse」

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「catch rats, especially with dogs」

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「desert one''s party or group of friends, for example, for one''s personal advantage」

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「employ scabs or strike breakers in」

PrepTutorEJDIC   license prepejdic

「『ネズミ』 / ひきょう者,裏切り者 / ネズミをつかまえる / 《話》(人を)裏切る,密告する《+『on』+『名』〈人〉》」

filtration」

  [★]

filterfiltrateleach

WordNet   license wordnet

「the process whereby fluids pass through a filter or a filtering medium」

WordNet   license wordnet

「the act of changing a fluid by passing it through a filter」

PrepTutorEJDIC   license prepejdic

「ろ過,ろ過作用」

rating」

  [★]

  • n.

WordNet   license wordnet

「standing or position on a scale」

PrepTutorEJDIC   license prepejdic

「〈C〉〈U〉(品質・技量などによる)格づけ,評価 / 〈C〉(個人・会社の経済的な)信用度 / 〈C〉(トン・馬力による)(船舶・車)の等級 / 〈C〉(テレビ・ラジオの)視聴率」

glomerular」

  [★]

  • adj.
  • 糸球体の、腎糸球体の
glomeruliglomeruluskidney glomerulusrenal glomerulirenal glomerulus

WordNet   license wordnet

「of or relating to glomeruli」




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