globin

出典: meddic

グロビン

apohemoglobinbeta-globingamma-globin

WordNet   license wordnet

「a colorless protein obtained by removing heme from hemoglobin; the oxygen carrying compound in red blood cells」
hematohiston, haematohiston

Wikipedia preview

出典(authority):フリー百科事典『ウィキペディア(Wikipedia)』「2014/06/18 19:50:37」(JST)

wiki en

[Wiki en表示]

UpToDate Contents

全文を閲覧するには購読必要です。 To read the full text you will need to subscribe.

英文文献

  • Effect of hypoxia on lung gene expression and proteomic profile: Insights into the pulmonary surfactant response.
  • Olmeda B1, Umstead TM2, Silveyra P2, Pascual A3, López-Barneo J3, Phelps DS2, Floros J2, Pérez-Gil J4.Author information 1Dept. Bioquímica, Fac. Biología, Universidad Complutense, Madrid, Spain.2Center for Host Defense, Inflammation, and Lung Disease (CHILD), Department of Pediatrics, The Pennsylvania State University College of Medicine, Hershey, PA, USA.3Instituto de Biomedicina de Sevilla (IBiS), Hospital Universitario Virgen del Rocío/CSIC/Universidad de Sevilla, Sevilla, Spain.4Dept. Bioquímica, Fac. Biología, Universidad Complutense, Madrid, Spain. Electronic address: jperezgil@bio.ucm.es.AbstractExposure of lung to hypoxia has been previously reported to be associated with significant alterations in the protein content of bronchoalveolar lavage (BAL) and lung tissue. In the present work we have used a proteomic approach to describe the changes in protein complement induced by moderate long-term hypoxia (rats exposed to 10% O2 for 72h) in BAL and lung tissue, with a special focus on the proteins associated with pulmonary surfactant, which could indicate adaptation of this system to limited oxygen availability. The analysis of the general proteomic profile indicates a hypoxia-induced increase in proteins associated with inflammation both in lavage and lung tissue. Analysis at mRNA and protein levels revealed no significant changes induced by hypoxia on the content in surfactant proteins or their apparent oligomeric state. In contrast, we detected a hypoxia-induced significant increase in the expression and accumulation of hemoglobin in lung tissue, at both mRNA and protein levels, as well as an accumulation of hemoglobin both in BAL and associated with surface-active membranes of the pulmonary surfactant complex. Evaluation of pulmonary surfactant surface activity from hypoxic rats showed no alterations in its spreading ability, ruling out inhibition by increased levels of serum or inflammatory proteins.
  • Journal of proteomics.J Proteomics.2014 Apr 14;101:179-91. doi: 10.1016/j.jprot.2014.02.019. Epub 2014 Feb 24.
  • Exposure of lung to hypoxia has been previously reported to be associated with significant alterations in the protein content of bronchoalveolar lavage (BAL) and lung tissue. In the present work we have used a proteomic approach to describe the changes in protein complement induced by moderate long-
  • PMID 24576641
  • Multiple physical stresses induce γ-globin gene expression and fetal hemoglobin production in erythroid cells.
  • Schaeffer EK1, West RJ1, Conine SJ1, Lowrey CH2.Author information 1Department of Medicine, Geisel School of Medicine, Dartmouth College, Hanover, NH 03755, USA; Department of Pharmacology and Toxicology, Geisel School of Medicine, Dartmouth College, Hanover, NH 03755, USA; Program in Experimental and Molecular Medicine, Geisel School of Medicine, Dartmouth College, Hanover, NH 03755, USA; Norris Cotton Cancer Center, Dartmouth-Hitchcock Medical Center, Lebanon, NH 03756, USA.2Department of Medicine, Geisel School of Medicine, Dartmouth College, Hanover, NH 03755, USA; Department of Pharmacology and Toxicology, Geisel School of Medicine, Dartmouth College, Hanover, NH 03755, USA; Program in Experimental and Molecular Medicine, Geisel School of Medicine, Dartmouth College, Hanover, NH 03755, USA; Norris Cotton Cancer Center, Dartmouth-Hitchcock Medical Center, Lebanon, NH 03756, USA. Electronic address: Christopher.H.Lowrey@dartmouth.edu.AbstractIncreased fetal hemoglobin (HbF) expression is beneficial for β-hemoglobinopathy patients; however, current inducing agents do not possess the ideal combination of efficacy, safety and ease of use. Better understanding the mechanisms involved in γ-globin gene induction is critical for designing improved therapies, as no complete mechanism for any inducing agent has been identified. Given the cytotoxic nature of most known inducing drugs, we hypothesized that γ-globin is a cell stress response gene, and that induction occurs via activation of cell stress signaling pathways. We tested this hypothesis by investigating the ability of physical stresses including heat-shock (HS), UV- and X-irradiation and osmotic shock to increase γ-globin gene expression in erythroid cells. Experiments in K562 and KU812 cells showed that each of these stresses increased steady-state γ-globin mRNA levels, but only after 3-5days of treatments. HS and UV also increased γ-globin mRNA and HbF levels in differentiating primary human erythroid cells. Mechanistic studies showed that HS affects γ-globin mRNA at multiple levels, including nascent transcription and transcript stability, and that induction is dependent on neither the master regulator of the canonical HS response, HSF1, nor p38 MAPK. Inhibitor panel testing identified PI3K inhibitor LY294002 as a novel inducing agent and revealed potential roles for NFκB and VEGFR/PDGFR/Raf kinases in HS-mediated γ-globin gene induction. These findings suggest that cell stress signaling pathways play an important role in γ-globin gene induction and may provide novel targets for the pharmacologic induction of fetal hemoglobin.
  • Blood cells, molecules & diseases.Blood Cells Mol Dis.2014 Apr;52(4):214-24. doi: 10.1016/j.bcmd.2013.10.007. Epub 2013 Dec 5.
  • Increased fetal hemoglobin (HbF) expression is beneficial for β-hemoglobinopathy patients; however, current inducing agents do not possess the ideal combination of efficacy, safety and ease of use. Better understanding the mechanisms involved in γ-globin gene induction is critical for designing im
  • PMID 24314748
  • The diagnosis and molecular analysis of a novel 21.9kb deletion (Qinzhou type deletion) causing α(+) thalassemia.
  • Long J1, Yan S2, Lao K2, Pang W2, Ye X2, Sun L2.Author information 1Laboratory of Medical Genetics, Qinzhou Maternal and Child Health Care Hospital, Guangxi 535099, PR China. Electronic address: lab@longju.net.2Laboratory of Medical Genetics, Qinzhou Maternal and Child Health Care Hospital, Guangxi 535099, PR China.Abstractα-Thalassemia is a common single-gene genetic disease that can cause Hb Bart's hydrops fetalis and Hb H disease in tropical and subtropical regions. When examining conventional thalassemia genes, an only detected --(SEA) genotype sample needs further analysis. In doing so, we found a novel 21.9kb deletion (Qinzhou type deletion). The deletion position of the novel 21.9kb deletion is from 14373bp to 36299bp of the α-globin gene cluster (NG_000006.1); thus, there exists a 21927bp sequence deletion, into which a 29bp sequence is added. After sequence analysis, a group of Gap-PCR primers were synthesized to diagnose this novel thalassemia genotype. Through pedigree analysis, we deduced that the propositus obtained the novel alleles from her mother. The genotype of this propositus is --(SEA)/-α(21.9) and its phenotype conforms to the characteristics of Hb H disease, establishing that the combination between -α(21.9) genotype and α(0) genotype can lead to Hb H disease. By molecular analysis, we established that this case fits the characteristic of an α(+) thalassemia genotype.
  • Blood cells, molecules & diseases.Blood Cells Mol Dis.2014 Apr;52(4):225-9. doi: 10.1016/j.bcmd.2013.10.005. Epub 2013 Nov 10.
  • α-Thalassemia is a common single-gene genetic disease that can cause Hb Bart's hydrops fetalis and Hb H disease in tropical and subtropical regions. When examining conventional thalassemia genes, an only detected --(SEA) genotype sample needs further analysis. In doing so, we found a novel 21.9kb d
  • PMID 24225490

和文文献

  • A high concentration of triiodothyronine attenuates the stimulatory effect on hemin-induced erythroid differentiation of human erythroleukemia K562 cells
  • , , , , , ,
  • Endocrine Journal 62(5), 431-440, 2015
  • … Lower concentrations of T3 had a stimulatory effect on hemin-induced hemoglobin production (1 and 10 nM), CD71 expression (0.1 nM), and α-globin mRNA expression (1 nM), while a higher concentration of T3 (100 nM) abrogated the stimulatory effect on these parameters. …
  • NAID 130005071801
  • Possible production of arsenic hemoglobin adducts via exposure to arsine
  • , , [他], , , , ,
  • Journal of Occupational Health 57(2), 161-168, 2015
  • … Results: In the exposed samples, the arsenic concentration in the fraction containing immunocomplexes was higher when immunoprecipitation was conducted with an anti-globin antibody. … Conclusions: Globin forms an adduct with arsenic after both in vitro and in vivo exposure to arsine. …
  • NAID 130005066086
  • HbA1cが偽性高値を示したために経口血糖降下薬の投与を受けた非糖尿病異常ヘモグロビンの2例
  • 清水 彩洋子,平良 暁子,畑﨑 聖弘,馬屋原 豊,平良 真人,古賀 正史
  • 糖尿病 58(2), 121-127, 2015
  • HbA1cは血糖コントロール指標として広く用いられているが,貧血や異常ヘモグロビンを有する患者のHbA1cは血糖コントロールを正しく反映しない.今回,HbA1cが偽性高値を示したために,経口血糖降下薬の投与を受けた非糖尿病異常ヘモグロビンの2例を経験した.2例とも高血糖は認めなかったが,免疫法で測定したHbA1cが高値を示した.1例はスルホニルウレア薬の投与で低血糖をきたしたが,他の1例はDPP4 …
  • NAID 130004905477

関連リンク

バイオテクノロジーに関する用語を集めました。 ... ヘモグロビンを構成するタンパク質の1つ。成人の正常ヘモグロビンのタンパク質部分はα-グロビン鎖2本とβ-グロビン鎖2本からなっている。
Globin definition, the protein component of hemoglobin, made up of alpha and beta chains. See more. Thesaurus Translate Puzzles & Games Reference Word of the Day Blog Slideshows Apps by Dictionary My Account Log Out ...

関連画像

Evolution of alpha and beta globin gene  Gafas > Globin Clear Red Revo SunglassesGlobin gene productionTwo tertiary structure alpha globin GLOBIN_222.pngAn example of the globin fold, the oxygen


★リンクテーブル★
リンク元グロビン」「apohemoglobin」「gamma-globin」「beta-globin
拡張検索hemoglobinemia
関連記事glob

グロビン」

  [★]

globin
グロビン蛋白質 globin protein


apohemoglobin」

  [★]

アポヘモグロビングロビン

globin

gamma-globin」

  [★]

beta-globinglobin


beta-globin」

  [★]

βグロビン

gamma-globinglobin

hemoglobinemia」

  [★] ヘモグロビン血症血色素血症


WordNet   license wordnet

「presence of excessive hemoglobin in the blood plasma」
haemoglobinemia


glob」

  [★]

PrepTutorEJDIC   license prepejdic

「(液体の)小滴,しずく / (粘土・クリームなどの)球形の固まり」


"http://meddic.jp/globin" より作成


★コメント★

[メモ入力エリア]
※コメント5000文字まで
ニックネーム:
コメント:




表示
個人用ツール


  meddic.jp

リンク
連絡