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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2012/05/06 17:24:06」(JST)

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Gliomatosis cerebri (infiltrative diffuse astrocytosis) is a rare primary brain tumor. It is commonly characterized by diffuse infiltration of the brain with neoplastic glial cells that affect various areas of the cerebral lobes.^[1] Glimatosis Cerebi behaves like a malignant tumor that is very similar to Glioblastoma.

While gliomatosis cerebri can occur at any age, it is generally found in the third and fourth decades of life.

Presentation

It may affect any part of the brain or even the spinal cord, optic nerve and compact white matter. Clinical manifestations are indefinite, and include headache, seizures, visual disturbances, corticospinal tract deficits, lethargy, and dementia. A case of gliomatosis cerebri presenting as rapidly progressive dementia and Parkinson's disease like symptoms was described in an 82 year old woman.^[2]

Diagnosis

Before the advent of MRI, diagnosis was generally not established until autopsy. Even with MRI, however, diagnosis is difficult.^[3] Typically, gliomatosis cerebri appears as a diffuse, poorly circumscribed, infiltrating non-enhancing lesion that is hyperintense on T2-weighted images and expands the cerebral white matter. It is difficult to distinguish from highly infiltrative anaplastic astrocytoma or GBM.^[4]

Prognosis

The prognosis for gliomatosis cerebri is generally poor, with a median survival time of only 12 months.^[5] Surgery is not practical considering the extent of the disease, standard chemotherapy (nitrosourea) has been unsuccessful, and while brain irradiation can stabilize or improve neurologic function in some patients, its impact on survival has yet to be proven.^{[citation needed]}

Notes

^ Gliomatosis Cerebri, MedPix : 923 - Medical Image Database and Atlas
^ http://jmedicalcasereports.com
^ Bendszus M, Warmuth-Metz M, Klein R, et al. (2000). "MR spectroscopy in gliomatosis cerebri". AJNR Am J Neuroradiol 21 (2): 375–80. PMID 10696026. http://www.ajnr.org/cgi/pmidlookup?view=long&pmid=10696026.
^ "Radiology, University of Rochester Medical Center". http://www.urmc.rochester.edu/smd/Rad/neurocases/Neurocase01.htm. Retrieved 2008-02-06.
^ Gliomatosis Cerebri - My Child Has - Children's Hospital Boston

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Japanese Journal

画像的に多巣性の進展経過を示した大脳膠腫症の1例

佐久嶋研,山田萌美,久保田佳奈子 [他]
臨床神経学 51(2), 145-148, 2011-02
NAID 40018714159

2. 多房性嚢胞形成を伴うgliomatosis cerebriの1例（第43回群馬脳腫瘍研究会<一般演題1>）

本徳浩二,曲澤聡,石原淳治,橋場康弘,吉田カツ江
The Kitakanto medical journal 60(1), 87-87, 2010-02-01
NAID 120002139554

Related Pictures

★リンクテーブル★

リンク元	「頭蓋内圧亢進」「星状芽細胞腫」「polar spongioblastoma」「neuroepithelial neoplasm」「neuroepithelial tumor」
関連記事	「cerebri」

「頭蓋内圧亢進」

Gliomatosis cerebri
	Classification and external resources
	; Axial fluid-attenuated inversion recovery MRI image demonstrating tumor-related infiltration involving both temporal lobes (Short arrow), and the substantia nigra (Long arrow).
ICD-10	ICD9 = Template:ICD9 191.0
ICD-O:	M9381/3
MeSH	D018302

　　[★]

英: intracranial hypertension, increased intracranial pressure
同: 脳圧亢進 brain hypertension
関: 頭蓋内圧、頭蓋内圧亢進症

PON.594-595