gla domains

出典: meddic

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  • Discovery of novel membrane binding structures and functions.
  • Kufareva I1, Lenoir M, Dancea F, Sridhar P, Raush E, Bissig C, Gruenberg J, Abagyan R, Overduin M.
  • Biochemistry and cell biology = Biochimie et biologie cellulaire.Biochem Cell Biol.2014 Dec;92(6):555-63. doi: 10.1139/bcb-2014-0074. Epub 2014 Sep 18.
  • The function of a protein is determined by its intrinsic activity in the context of its subcellular distribution. Membranes localize proteins within cellular compartments and govern their specific activities. Discovering such membrane-protein interactions is important for understanding biological me
  • PMID 25394204
  • The length of the linker between the epidermal growth factor-like domains in factor VIIa is critical for a productive interaction with tissue factor.
  • Persson E1, Madsen JJ, Olsen OH.
  • Protein science : a publication of the Protein Society.Protein Sci.2014 Dec;23(12):1717-27. doi: 10.1002/pro.2553. Epub 2014 Oct 14.
  • Formation of the factor VIIa (FVIIa)-tissue factor (TF) complex triggers the blood coagulation cascade. Using a structure-based rationale, we investigated how the length of the linker region between the two epidermal growth factor (EGF)-like domains in FVIIa influences TF binding and the allosteric
  • PMID 25234571
  • Matrix Gla protein and osteocalcin: from gene duplication to neofunctionalization.
  • Cancela ML1, Laizé V2, Conceição N2.
  • Archives of biochemistry and biophysics.Arch Biochem Biophys.2014 Nov 1;561:56-63. doi: 10.1016/ Epub 2014 Jul 25.
  • Osteocalcin (OC or bone Gla protein, BGP) and matrix Gla protein (MGP) are two members of the growing family of vitamin K-dependent (VKD) proteins. They were the first VKD proteins found not to be involved in coagulation and synthesized outside the liver. Both proteins were isolated from bone althou
  • PMID 25068814


  • The relative orientation of Gla and EGF domains in coagulation factor X is altered by Ca^<2+> binding to the first EGF domain. A combined NMR-small angle X-ray scattering study


The 3D structures of several Gla domains have been solved. [4] [5] Calcium ions induce conformational changes in the Gla domain and are necessary for the Gla domain to fold properly. A common structural feature of functional [5] ...
The term ‘Gla-domain’ is used to describe the γ-carboxyglutamic acid (Gla)-containing region of certain vitamin K–dependent proteins such as prothrombin and factor IX. The domain comprises the first 45 or so amino acids at the N ...


 to the membrane through its GLA domain Gla domains of vitamin K−dependentCardiovascular ResearchThe reaction requires different steps:the N-terminal domains of protein S ( Gla  GLA domains , rich in gamma




WordNet   license wordnet

「showing or causing joy and pleasure; especially made happy; "glad you are here"; "glad that they succeeded"; "gave a glad shout"; "a glad smile"; "heard the glad news"; "a glad occasion"」

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「《補語にのみ用いて》『うれしい』,楽しい,喜んで / 《『be glad to』 do》《未来形で》『喜んで』(『進んで』)…『する』(willing) / 《名詞の前にのみ用いて》(物事・表情・声などが)『喜ばしい』,うれしそうな」

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WordNet   license wordnet

「eagerly disposed to act or to be of service; "glad to help"」

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「feeling happy appreciation; "glad of the fire''s warmth"」



  • n.

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「territory over which rule or control is exercised; "his domain extended into Europe"; "he made it the law of the land"」
demesne, land

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「(mathematics) the set of values of the independent variable for which a function is defined」
domain of a function

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「(国の)領地,領土;(個人の)所有地 / (関心・活動などの)範囲,分野 / (個人・一族の)所有地 / (数学で)変域(関数の独立変数がとる値の集合)」


  [★] グラム


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「a unit of force equal to the force exerted by gravity; used to indicate the force to which a body is subjected when it is accelerated」
gee, g-force


  [★] γ-カルボキシグルタミン酸



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