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Gestonorone caproate (INN, USAN, JAN) (brand names Depostat, Primostat), also known as gestronol hexanoate (BANM), as well as 17α-hydroxy-19-norprogesterone caproate, is a synthetic, steroidal progestin.^[1]^[2]^[3]^[4]^[5] As a depot administered via intramuscular injection, it is used in the treatment of benign prostatic hypertrophy (BPH) and endometrial cancer.^[6]

References

^ J. Elks (14 November 2014). The Dictionary of Drugs: Chemical Data: Chemical Data, Structures and Bibliographies. Springer. pp. 595–. ISBN 978-1-4757-2085-3.
^ Index Nominum 2000: International Drug Directory. Taylor & Francis. January 2000. p. 488. ISBN 978-3-88763-075-1.
^ I.K. Morton; Judith M. Hall (6 December 2012). Concise Dictionary of Pharmacological Agents: Properties and Synonyms. Springer Science & Business Media. pp. 132–. ISBN 978-94-011-4439-1.
^ Muller (19 June 1998). European Drug Index: European Drug Registrations, Fourth Edition. CRC Press. pp. 338–. ISBN 978-3-7692-2114-5.
^ William Andrew Publishing (22 October 2013). Pharmaceutical Manufacturing Encyclopedia, 3rd Edition. Elsevier. pp. 1761–1762. ISBN 978-0-8155-1856-3.
^ David E. Thurston (22 November 2006). Chemistry and Pharmacology of Anticancer Drugs. CRC Press. pp. 154–155. ISBN 978-1-4200-0890-6.

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UpToDate Contents

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1. 自然早産のリスクを低下させるためのプロゲステロン補充 progesterone supplementation to reduce the risk of spontaneous preterm birth
2. 頸管無力症 cervical insufficiency
3. 産婦人科学の最新情報 whats new in obstetrics and gynecology
4. 自然早産の予防 prevention of spontaneous preterm birth
5. Second-trimester evaluation of cervical length for prediction of spontaneous preterm birth

English Journal

Cyproterone synthesis, recognition and controlled release by molecularly imprinted nanoparticle.

Asadi E1, Azodi-Deilami S, Abdouss M, Khaghani S.
Applied biochemistry and biotechnology.Appl Biochem Biotechnol.2012 Aug;167(7):2076-87. doi: 10.1007/s12010-012-9748-y. Epub 2012 Jun 5.
In this study, we used novel synthetic conditions of precipitation polymerization to obtain nanosized cyproterone molecularly imprinted polymers for application in the design of new drug delivery systems. The scanning electron microscopy images and Brunauer-Emmett-Teller analysis showed that molecul
PMID 22669687

Progestins for the prevention of spontaneous preterm birth: review and implications of recent studies.

O'Brien JM1, Lewis DF.
The Journal of reproductive medicine.J Reprod Med.2009 Feb;54(2):73-87.
Progesterone plays a central role in the mechanisms of parturition in many species. Despite remarkable advances in our understanding of this hormone's mechanism of action, its roles in human pregnancy maintenance and parturition are not fully appreciated. Proper scientific hypothesis testing of prog
PMID 19301570

Preterm birth prevention by 17 alpha-hydroxyprogesterone caproate vs. daily nursing surveillance.

Rittenberg C1, Newman RB, Istwan NB, Rhea DJ, Stanziano GJ.
The Journal of reproductive medicine.J Reprod Med.2009 Feb;54(2):47-52.
OBJECTIVE: To compare the incidence of spontaneous recurrent preterm delivery (SPTD) between women receiving 17 alpha-hydroxyprogesterone caproate (17P) and women receiving daily perinatal nursing surveillance (dPNS) with home uterine activity monitoring.STUDY DESIGN: Women enrolled for dPNS or week
PMID 19301566

Japanese Journal

前立腺肥大症に対する抗アンドロゲン療法 : 薬剤の紹介と臨床成績

蟹本雄右,岡田謙一郎
泌尿器科紀要 37(11), 1423-1428, 1991-11
… The progestational agents such as gestonorone caproate, chlormadinone acetate and allylestrenol suppress more or less sexual function by interference of the pituitary-gonadal axis. …
NAID 120002158078

前立腺超音波計測6年間の経験 : 第3報 : 肥大症前立腺重量の抗アンドロゲン療法による変化

林田真和,木村明,樋口照男
日本泌尿器科學會雜誌 77(9), 1467-1477, 1986-09-20
… gestonorone caproate=GC投与例7例).以上105例の前立腺重量の経時的変化を検討することにより,以下の知見を得た.1)CMA投与例98例中85例,GC投与例7例中6例に前立腺重量の縮小が見られた.縮小率の平均は各々31.7%及び20.7%であった.2)CMA投与中止後まで経過観察された25例では,前立腺重量平均はCMA投与後約4ヵ月で有意に縮少したが,CMA投与中止約1年後までに,投与前値レベルまで再増大を示した.3)上記25例中CMAの再投 …
NAID 110003066032

前立腺肥大症に対するDepostat(Gestonorone Caproate,SH-582)の臨床効果-4-

伊東健治,百瀬俊郎
西日本泌尿器科 45(4), p921-925, 1983-08
NAID 40002795095

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★リンクテーブル★

リンク元	「ゲストノロン」「カプロン酸ゲストノロン」
関連記事	「caproate」「gestonorone」

「ゲストノロン」

Gestonorone caproate
Systematic (IUPAC) name
	3,20-Dioxo-19-norpregn-4-en-17-yl hexanoate
Identifiers
CAS Number	1253-28-7
ATC code	G03DA01 L02AB03
PubChem	CID: 443881
ChemSpider	391969
Synonyms	Gestonorone hexanoate, gestronol hexanoate, gestronol caproate, norhydroxyprogesterone caproate
Chemical data
Formula	C26H38O4
Molecular mass	414.57752 g/mol
	SMILES CCCCCC(=O)OC1(CCC2C1(CCC3C2CCC4=CC(=O)CCC34)C)C(=O)C ;