English Journal

In vitro anti-inflammatory effects of diterpenoids and sesquiterpenoids from traditional Chinese medicine Siegesbeckia pubescens.

Wang R1, Liu YQ2, Ha W3, Shi YP4, Hwang TL5, Huang GJ6, Wu TS7, Lee KH8.
Bioorganic & medicinal chemistry letters.Bioorg Med Chem Lett.2014 Aug 15;24(16):3944-7. doi: 10.1016/j.bmcl.2014.06.039. Epub 2014 Jun 19.
Oxidative stress imposed by reactive oxygen species plays a crucial role in pathophysiology of inflammatory diseases. In the present study, sesquiterpenoids and diterpenoids isolated from Siegesbeckia pubescens, a Chinese traditional medicine used to treat arthritis, were evaluated for inhibition of
PMID 24997688

Wu J1, Wang G2, Du X3, Song N1, Zou Z4, Chen J1, Zhang Y1, Li T1, Wang X1, Kuang H1.
Fitoterapia.Fitoterapia.2014 Jul;96:18-24. doi: 10.1016/j.fitote.2014.03.025. Epub 2014 Apr 4.
A new caryophyllane derivative, caryophyllenol A, and a new germacrane derivative, isovolvalerenal D, together with 11 known sesquiterpenoids, were isolated from a petroleum ether partition of the roots and rhizomes of Valeriana amurensis. Structure elucidation of caryophyllenol A and isovolvalerena
PMID 24704552

Expression, purification and activity assay of a patchoulol synthase cDNA variant fused to thioredoxin in Escherichia coli.

Hartwig S1, Frister T1, Alemdar S1, Li Z1, Krings U2, Berger RG2, Scheper T1, Beutel S3.
Protein expression and purification.Protein Expr Purif.2014 May;97:61-71. doi: 10.1016/j.pep.2014.02.003. Epub 2014 Feb 25.
Probing a cDNA library extracted from Pogostemon cablin (Indian Patchouli) with gene specific primers, a variant of patchoulol synthase PTS (GenBank acc. No.: AY508730) was amplified, cloned, and sequenced. The amino acid sequence deduced from the cloned cDNA exhibited a sequence variation of 3.4% c
PMID 24576659

Japanese Journal

下村昌也,鈴木宗典,伊藤隆,關光,西澤具子,南雲清二,秋田徹,前嶋一宏,高上馬希重,村中俊哉
植物化学調節学会研究発表記録集 (44), 49, 2009-10-06
… We previously demonstrated that sesquiterpenoid profile was correlated with gene expression of sesquiterpene synthase among A. … were collected and their sesquiterpenoid profile was analysed by GC-MS. Germacrane, copaene, and caryophyllane were commonly detected. … For sesquiterpenes commonly detected, genes for corresponding sesquiterpene cyclases should be commonly existed in Artemisia spp. …
NAID 110007468295

鈴木宗典,關光,下村昌也,小森彩,西澤具子,南雲清二,高上馬希重,村中俊哉
植物化学調節学会研究発表記録集 (43), 85, 2008-10-06
… Because Artemisia annua contain artemisinin widely used for anti-malaria drug, sesquiterpene biosynthesis in A. … Five sesquiterpene synthases have been cloned and characterized from the plant species. … So far, we reported that sesquiterpene profile was highly correlated with gene expression between A. …
NAID 110007468245

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Chemical & pharmaceutical bulletin 56(6), 843-846, 2008-06-01
… Two new germacrane sesquiterpenes, called salviadienol A (1) and salviadienol B (2), together with five known compounds, methyl-ent-4-epi-agath-18-oate (3), angelicoidenol (4), clovane-2β,9α-diol (5), dehydrovomifoliol (6) and blumenol A (7), were isolated from Salvia chinensis. …
NAID 110006684286