geranylgeranylation

• ゲラニルゲラニル化

関

farnesylation、isoprenylation、prenylation

Wikipedia preview

出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2014/01/23 18:52:04」(JST)

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Geranylgeranylation is a form of prenylation, which is a post-translational modification of proteins that involves the attachment of one or two 20-carbon lipophilic geranylgeranyl isoprene units from geranylgeranyl diphosphate to one or two cysteine residue(s) at the C-terminus of specific proteins. Prenylation (including geranylgeranylation) is thought to function, at least in part, as a membrane anchor for proteins.

The process of geranylgeranylation can be catalyzed by either geranylgeranyl transferase I (GGTase I) or Rab GGTase (also GGTase II). GGTase I catalyzes the addition of one geranylgeranyl group onto the C-terminal consensus sequence CAAL (somewhat similar to farnesyltransferase reactions), where C=cysteine, A=any aliphatic amino acid, and L=leucine. Rab GGTase adds a total of two geranylgeranyl groups onto two cysteine residues at the C-terminal consensus sequence CXC or XXCC. The source of the geranylgeranyl group is geranylgeranyl diphosphate, which is synthesized from the isoprenoid biosynthetic pathway.

An example of this can be seen in the lipid anchoring of the Rho GTPase family of signaling molecules and the gamma subunit of heterotrimeric G proteins.

References

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Japanese Journal

• Molecular characterization and mRNA expression analysis of farnesyl transferase and geranylgeranyl transferase genes in the silkworm Bombyx mori

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• NAID 130004464169

• RhoA and Rac1 Changes in the Atherosclerotic Lesions of WHHLMI Rabbits

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• Journal of Atherosclerosis and Thrombosis 16(6), 846-856, 2010
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• Journal of atherosclerosis and thrombosis 16(6), 846-856, 2009-12-31
• NAID 10026144512

Related Links

• What does geranylgeranylation mean? - Definitions.net

Definition of geranylgeranylation in the Definitions.net dictionary. Meaning of geranylgeranylation. What does geranylgeranylation mean? Information and translations of geranylgeranylation in the most comprehensive dictionary ...

• Geranylgeranylation of Rab GTPases - The Journal of Lipid ...

Thematic review series: Lipid Posttranslational Modifications Geranylgeranylation of Rab GTPases Ka Fai Leung, Rudi Baron and Miguel C. Seabra* Molecular and Cellular Medicine, Division of Biomedical Sciences, Imperial College ...

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★リンクテーブル★

リンク元	「farnesylation」「ゲラニルゲラニル化」「prenylation」「isoprenylation」
拡張検索	「protein geranylgeranylation」

「farnesylation」

　　[★]

• ファルネシル化

関

farnesylate、geranylgeranylation、isoprenylation、prenylation

「ゲラニルゲラニル化」

　　[★]

英

geranylgeranylation

関

イソプレニル化、ファルネシル化、プレニル化

「prenylation」

　　[★]

• プレニル化

関

farnesylation、geranylgeranylation、isoprenylation、prenylated

「isoprenylation」

　　[★]

• イソプレニル化

関

farnesylation、geranylgeranylation、prenylation

「protein geranylgeranylation」

　　[★]

タンパク質ゲラニルゲラニル化

関

protein farnesylation、protein isoprenylation、protein prenylation